Aberrant plasma IL-7 and soluble IL-7 receptor levels indicate impaired T-cell response to IL-7 in human tuberculosis. [PDF]
PLoS Pathogens, 2017 T-cell proliferation and generation of protective memory during chronic infections depend on Interleukin-7 (IL-7) availability and receptivity. Regulation of IL-7 receptor (IL-7R) expression and signalling are key for IL-7-modulated T-cell functions ...
Christian Lundtoft +11 more
doaj +2 more sources
Increased bone marrow interleukin-7 (IL-7)/IL-7R levels but reduced IL-7 responsiveness in HIV-positive patients lacking CD4+ gain on antiviral therapy. [PDF]
PLoS ONE, 2010 BACKGROUND: The bone marrow (BM) cytokine milieu might substantially affect T-lymphocyte homeostasis in HIV-positive individuals. Interleukin-7 (IL-7) is a bone marrow-derived cytokine regulating T-cell homeostasis through a CD4+-driven feedback loop ...
Giusi Maria Bellistrì +9 more
doaj +3 more sources
A mechanistically novel peptide agonist of the IL-7 receptor that addresses limitations of IL-7 cytokine therapy. [PDF]
PLoS ONE, 2023 Interleukin (IL)-7 is broadly active on T-cell populations, and modified versions have been clinically evaluated for a variety of therapeutic applications, including cancer, lymphopenia, and infectious diseases; and found to be relatively well-tolerated ...
William J Dower +9 more
doaj +2 more sources
Empowerment of CAR-T Cells by IL-7 and IL-15 Boosts Their Efficacy Against HER2-Positive Tumors with Enhanced Expansion and Persistence [PDF]
CellsChimeric antigen receptor (CAR)-T cell therapy has achieved remarkable clinical success in B cell malignancies. However, its efficacy in solid tumors remains limited, in part due to suboptimal expansion, persistence, and restrained effector function ...
Zhehong Cheng +4 more
doaj +2 more sources
Advances in IL-7 Research on Tumour Therapy [PDF]
PharmaceuticalsInterleukin-7 (IL-7) is a versatile cytokine that plays a crucial role in regulating the immune system’s homeostasis. It is involved in the development, proliferation, and differentiation of B and T cells, as well as being essential for the ...
Chunxue Fu +5 more
doaj +2 more sources
Atovaquone attenuates experimental colitis by reducing neutrophil infiltration of colonic mucosa
Frontiers in Pharmacology, 2022 Ulcerative colitis (UC) is a chronic relapsing disease featuring aberrant accumulation of neutrophils in colonic mucosa and the luminal space. Although significant advances in UC therapy have been made with the development of novel biologics and small ...
Laura D. Manzanares +8 more
doaj +1 more source
IL‐7 is expressed in malignant mesothelioma and has a prognostic value
Molecular Oncology, 2022 Malignant pleural mesothelioma (MPM) is an aggressive cancer mainly related to asbestos exposure. Despite recent therapeutic advances, notably immunotherapies, the benefit remains limited and restricted to a small percentage of patients.
Hoa‐Le Mai +6 more
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Cancer Medicine, 2023 Purpose Addressing lymphopenia in cancer patients has been suggested as a novel immunotherapeutic strategy. As interleukin‐7 (IL‐7) is necessary for proliferation of lymphocytes and to increase total lymphocyte count (TLC), IL‐7 therapy has been ...
Stephen Ahn +5 more
doaj +1 more source
7. N’est-il d’histoire que d’historiens?
Journal of Interdisciplinary History of Ideas, 2021 Quand est-on historien ? Quand fait-on de l’histoire ? Faut-il être l’un pour faire l’autre ? Sous la présidence d’un historien, une quinzaine de représentants des sciences humaines et sociales pratiquées à l’université Paris 1 Panthéon-Sorbonne ont ...
Virginie Barrusse +14 more
doaj +1 more source
IL-7 in SARS-CoV-2 Infection and as a Potential Vaccine Adjuvant
Frontiers in Immunology, 2021 IL-7/IL-7R signaling is critical for development, maturation, maintenance and survival of many lymphocytes in the thymus and periphery. IL-7 has been used as immunotherapy in pre-clinical and clinical studies to treat cancer, HIV infection and sepsis ...
Yonas Bekele +2 more
doaj +1 more source