Results 1 to 10 of about 4,555,739 (141)

Forced expression of IL-7R promotes CD8 T cell cytotoxicity to self antigen. [PDF]

PLoS ONE, 2017
Cross-presentation of apoptotic cell associated antigens by immature dendritic cells prevents the activation of self reactive CD8 T cells. Tolerized self reactive CD8 T cells down-regulate IL-7R expression on their surface.
YuFeng Peng
doaj   +4 more sources

The Additive Inflammatory In Vivo and In Vitro Effects of IL-7 and TSLP in Arthritis Underscore the Therapeutic Rationale for Dual Blockade. [PDF]

PLoS ONE, 2015
The cytokines interleukin (IL)-7 and thymic stromal lymphopoietin (TSLP) signal through the IL-7R subunit and play proinflammatory roles in experimental arthritis and rheumatoid arthritis (RA).
Maarten R Hillen, Sarita A Y Hartgring, Cynthia R Willis, Timothy R D J Radstake, Cornelis E Hack, Floris P J G Lafeber, Joel A G van Roon   +6 more
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Aberrant plasma IL-7 and soluble IL-7 receptor levels indicate impaired T-cell response to IL-7 in human tuberculosis. [PDF]

PLoS Pathogens, 2017
T-cell proliferation and generation of protective memory during chronic infections depend on Interleukin-7 (IL-7) availability and receptivity. Regulation of IL-7 receptor (IL-7R) expression and signalling are key for IL-7-modulated T-cell functions ...
Christian Lundtoft, Anthony Afum-Adjei Awuah, Jens Rimpler, Kirstin Harling, Norman Nausch, Malte Kohns, Ernest Adankwah, Franziska Lang, Laura Olbrich, Ertan Mayatepek, Ellis Owusu-Dabo, Marc Jacobsen   +11 more
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IL-7R signaling activates widespread VH and DH gene usage to drive antibody diversity in bone marrow B cells

Cell Reports, 2021
Summary: Generation of the primary antibody repertoire requires V(D)J recombination of hundreds of gene segments in the immunoglobulin heavy chain (Igh) locus.
Amanda Baizan-Edge, Bryony A. Stubbs, Michael J.T. Stubbington, Daniel J. Bolland, Kristina Tabbada, Simon Andrews, Anne E. Corcoran   +6 more
doaj   +1 more source

Hepatitis B virus X protein promotes interleukin-7 receptor expression via NF-κB and Notch1 pathway to facilitate proliferation and migration of hepatitis B virus-related hepatoma cells

Journal of Experimental & Clinical Cancer Research, 2016
Background Interleukin-7 receptor (IL-7R) is involved in the abnormal function of solid tumors, but the role and regulatory mechanisms of IL-7R in HBV-related hepatocellular carcinoma (HCC) are still unclear. Methods Gene and protein expression levels of
Fanyun Kong, Wei Hu, Kai Zhou, Xiao Wei, Yanbo Kou, Hongjuan You, Kuiyang Zheng, Renxian Tang   +7 more
doaj   +1 more source

Interleukin-7 receptor blockade suppresses adaptive and innate inflammatory responses in experimental colitis

Journal of Inflammation, 2012
Background Interleukin-7 (IL-7) acts primarily on T cells to promote their differentiation, survival, and homeostasis. Under disease conditions, IL-7 mediates inflammation through several mechanisms and cell types. In humans, IL-7 and its receptor (IL-7R)
Willis Cynthia R, Seamons Audrey, Maxwell Joe, Treuting Piper M, Nelson Laurel, Chen Guang, Phelps Susan, Smith Carole L, Brabb Thea, Iritani Brian M, Maggio-Price Lillian   +10 more
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Comparative analysis of the expression of the soluble IL-7 receptor in patients with arthropathy

Медицинская иммунология, 2023
Arthropathy is one of the most prevalent diseases, which are based on the destruction and remodeling of cartilage and bone tissue. The inflammation that precedes destruction can be caused by mechanical stress on the joints, or by autoimmune reactions ...
A. V. Kolerova, O. A. Angelskaya, O. A. Chumasova, A. E. Sizikov, I. V. Shirinsky, V. S. Shirinsky, E. A. Blinova   +6 more
doaj   +1 more source

Interleukin-7 Modulates Anti-Tumor CD8+ T Cell Responses via Its Action on Host Cells. [PDF]

PLoS ONE, 2016
The adoptive transfer of antigen-specific CD8+ T cells is a promising approach for the treatment of chronic viral and malignant diseases. In order to improve adoptive T cell therapy (ATT) of cancer, recent strategies aim at the antibody-based blockade of
Katrin Deiser, Diana Stoycheva, Ute Bank, Thomas Blankenstein, Thomas Schüler   +4 more
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Differential requirement for Hoxa9 in the development and differentiation of B, NK, and DC-lineage cells from Flt3+ multipotential progenitors

BMC Immunology, 2013
Hoxa9 is a homeodomain transcription factor important for the generation of Flt3+hiIL-7R- lymphoid biased-multipotential progenitors, Flt3+IL-7R+ common lymphoid progenitors (CLPs), and B cell precursors (BCP) in bone marrow (BM).
Gwin Kimberly, Dolence Joseph J, Shapiro Mariya B, Medina Kay L   +3 more
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IL-7R blockade reduces post-myocardial infarction-induced atherosclerotic plaque inflammation in ApoE−/- mice

Biochemistry and Biophysics Reports, 2019
Modulating inflammation by targeting IL-1β reduces recurrent athero-thrombotic cardiovascular events without lipid lowering. This presents an opportunity to explore other pathways associated with the IL-1β signaling cascade to modulate the inflammatory ...
Peter M. Mihailovic, Wai Man Lio, Juliana Yano, Jianchang Zhou, Xiaoning Zhao, Kuang-Yuh Chyu, Prediman K. Shah, Bojan Cercek, Paul C. Dimayuga   +8 more
doaj   +1 more source