Results 21 to 30 of about 4,555,739 (141)

Transcriptional regulation of IL-7R alpha gene in T lymphocytes [PDF]

, 2010
99
Akçay, İzzet Mehmet
core   +4 more sources

New insights into roles of IL-7R gene as a diagnostic biomarker for post-stroke depression

Frontiers in Immunology
BackgroundPost-stroke depression (PSD) is the most prevalent neuropsychiatric complication following a stroke. The inflammatory theory suggests that PSD may be associated with an overactive inflammatory response.
Mengyu Liu, Mengyu Liu, Haochen Sun, Qun Yao, Duohao Wang, Jihong Zhang, Xing Ye, Xinyang Qi   +7 more
doaj   +3 more sources

New Insights into Roles of IL-7R Gene as a Therapeutic Target Following Intracerebral Hemorrhage

Journal of Inflammation Research
Jie Cui,1– 4,* Hongbin Wang,5,6,* Shiyao Liu,1– 4 Yiming Zhao1– 4 1Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, People’s Republic of China; 2National Clinical Research Center for ...
Cui J, Wang H, Liu S, Zhao Y
doaj   +1 more source

IL-7/IL-7R gene variants impact circulating IL-7/IL-7R homeostasis and ART-associated immune recovery status

A relationship between polymorphisms in genes encoding interleukin 7 (IL-7) and its cellular receptor (IL-7R) and antiretroviral therapy (ART)-associated immune recovery in HIV subjects has been previously reported. However, details of this relationship remain unclear, and the association of these polymorphisms with circulating IL-7/IL-7R levels is ...
Ceausu, Andra, Rodríguez-Gallego, Esther||, Peraire, Joaquim||, López-Dupla, M., Domingo Pedrol, Pedro||, Viladés, Consuelo||, Vidal-Gonzalez, J., Perpiñán, C., Pacheco, Yolanda M.||, Veloso, S., Alba, Verónica||, Vargas Laguna, Montserrat||, Castellano, Alfonso J., Ruiz-Mateos, E., Mallolas Masferrer, Josep||, Vidal, Francisco||, Rull, A.   +16 more
openaire   +2 more sources

Gene variation in IL-7 receptor (IL-7R)α affects IL-7R response in CD4+ T cells in HIV-infected individuals [PDF]

Scientific Reports, 2017
AbstractOptimal CD4+ T cell recovery after initiating combination antiretroviral treatment (cART) in HIV infection reduces risk of morbidity and mortality. T-allele homozygosity (‘TT’) in the single nucleotide polymorphism, rs6897932(C/T), in the IL-7 receptor α (IL-7RA) is associated with faster CD4+ T cell recovery after cART initiation compared to C-
Hartling, Hans Jakob, Ryder, Lars P., Ullum, Henrik, Odum, Niels, Nielsen, Susanne Dam   +4 more
openaire   +3 more sources

A Function for IL-7R for CD4+CD25+Foxp3+ T Regulatory Cells [PDF]

The Journal of Immunology, 2008
Abstract The IL-2/IL-2R interaction is important for development and peripheral homeostasis of T regulatory (Treg) cells. IL-2- and IL-2R-deficient mice are not completely devoid of Foxp3+ cells, but rather lack population of mature CD4+CD25+Foxp3high Treg cells and contain few immature CD4+CD25−Foxp3low T cells. Interestingly, common
Allison L, Bayer, Joon Youb, Lee, Anabel, de la Barrera, Charles D, Surh, Thomas R, Malek   +4 more
openaire   +2 more sources

In patients with primary Sjögren’s syndrome innate-like MAIT cells display upregulated IL-7R, IFN-γ, and IL-21 expression and have increased proportions of CCR9 and CXCR5-expressing cells

Frontiers in Immunology, 2022
IntroductionMucosal-associated invariant T (MAIT) cells might play a role in B cell hyperactivity and local inflammation in primary Sjögren’s syndrome (pSS), just like previously studied mucosa-associated CCR9+ and CXCR5+ T helper cells.
Anneline C. Hinrichs, Anneline C. Hinrichs, Aike A. Kruize, Helen L. Leavis, Joel A. G. van Roon, Joel A. G. van Roon   +5 more
doaj   +1 more source

Characterization of Circulating IL-7R Positive Cell Populations for Early Detection of Pancreatic Ductal Adenocarcinoma [PDF]

, 2021
(1) Background: Pancreatic cancer is a high devastating disease with the lowest survival rate among all common cancers due to difficulties in early diagnosis.
Hyung Keun Lee, Dong Ki Lee, Sun-Hee Heo, So Young Kim, Eun-Ju Chang, Bongkun Choi, Sung Ill Jang   +6 more
core   +3 more sources

Interleukin-7 receptor Thr244Ile gene polymorphism and the risk of systemic lupus erythematosus

Journal of Medical Science, 2016
Aim. Recently, the IL-7 receptor (IL-7R) C>T (rs6897932) single nucleotide polymorphism (SNP), which causes a Thr244Ile substitution in the IL-7R ?-chain, has been suggested as a risk factor for SLE. Material and Methods.
Pawel Piotr Jagodzinski, Piotr Piotrowski, Marzena Olesińska   +2 more
doaj   +1 more source

IL‐7 is expressed in malignant mesothelioma and has a prognostic value

Molecular Oncology, 2022
Malignant pleural mesothelioma (MPM) is an aggressive cancer mainly related to asbestos exposure. Despite recent therapeutic advances, notably immunotherapies, the benefit remains limited and restricted to a small percentage of patients.
Hoa‐Le Mai, Sophie Deshayes, Thi‐Van‐Ha Nguyen, Virginie Dehame, Anne‐Laure Chéné, Sophie Brouard, Christophe Blanquart   +6 more
doaj   +1 more source