Results 11 to 20 of about 4,555,739 (141)

IL-15 sustains IL-7R-independent ILC2 and ILC3 development [PDF]

Nature Communications, 2017
ILC2 and ILC3 are generally thought to require IL-7. Here the authors use IL-7 ko mice and provide side-by-side comparison of ILCs from different tissues to show that IL-7 signalling is not required for intestinal ILC maintenance or function and that IL ...
Michelle L. Robinette, Jennifer K. Bando, Wilbur Song, Tyler K. Ulland, Susan Gilfillan, Marco Colonna   +5 more
doaj   +6 more sources

IL-7/IL-7R gene variants impact circulating IL-7/IL-7R homeostasis and ART-associated immune recovery status [PDF]

Scientific Reports, 2019
AbstractA relationship between polymorphisms in genes encoding interleukin 7 (IL-7) and its cellular receptor (IL-7R) and antiretroviral therapy (ART)-associated immune recovery in HIV subjects has been previously reported. However, details of this relationship remain unclear, and the association of these polymorphisms with circulating IL-7/IL-7R ...
Ceausu, Andrea, Rodríguez Gallego, Esther, Perair, Joaquim, López Dupla, Miguel, Domingo, Pere (Domingo Pedrol), Viladés, Consuelo, Vidal Gonzalez, Judit, Peraire, María, Perpiñán, Carles, Pacheco, Yolanda María, Veloso, Sergi, Alba, Verónica, Vargas, Montserrat, Castellano, Alfonso J., Ruíz Mateos, Ezequiel, Mallolas Masferrer, Josep, Vidal Marsal, Francisco, Rull, Anna   +17 more
core   +15 more sources

Flip the coin: IL-7 and IL-7R in health and disease [PDF]

Nature Immunology, 2019
The cytokine IL-7 and its receptor, IL-7R, are critical for T cell and, in the mouse, B cell development, as well as differentiation and survival of naive T cells, and generation and maintenance of memory T cells. They are also required for innate lymphoid cell (ILC) development and maintenance, and consequently for generation of lymphoid structures ...
João T. Barata, Scott K. Durum, Benedict Seddon   +2 more
core   +7 more sources

The Role of IL-7 and IL-7R in Cancer Pathophysiology and Immunotherapy

International Journal of Molecular Sciences, 2022
Interleukin-7 (IL-7) is a multipotent cytokine that maintains the homeostasis of the immune system. IL-7 plays a vital role in T-cell development, proliferation, and differentiation, as well as in B cell maturation through the activation of the IL-7 receptor (IL-7R). IL-7 is closely associated with tumor development and has been used in cancer clinical
Chunli Wang, Lingzu Kong, Seokmin Kim, Sunyoung Lee, Sechan Oh, Seona Jo, Inhwan Jang, Tae-Don Kim   +7 more
openaire   +3 more sources

Validation of IL-7R as an Immunological Biomarker for Human Pancreatic Ductal Adenocarcinoma [PDF]

Cancers, 2022
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer for which no early diagnostic method is available. The immune surveillance hypothesis suggests that the immune system plays crucial roles in tumor development and progression. We validated a PDAC-specific biomarker derived from peripheral blood mononuclear cells (PBMCs) to facilitate early
Sung-Ill Jang, Jae-Hee Cho, So-Young Kim, In-Young Hong, Joon-Seong Park, Hye-Sun Lee, Goeun Park, Jong-Kyoung Kim, Hyung-Keun Lee, Dong-Ki Lee   +9 more
core   +8 more sources

Editorial: Hijacking the IL-7/IL-7R system in HIV infection [PDF]

Journal of Leukocyte Biology, 2011
The IL-7/IL-7R pathway is activated during HIV-induced lymphopenia, but its function is limited by reduced responsiveness to IL-7.
Mirko Paiardini
openaire   +3 more sources

IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: An update

Advances in Biological Regulation, 2019
Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Rα and γc) are essential for normal lymphoid development. In their absence, severe combined immunodeficiency occurs. By contrast, excessive IL-7/IL-7R-mediated signaling can drive lymphoid leukemia development, disease acceleration and resistance to chemotherapy. IL-7 and IL-7R activate
Oliveira, Mariana L., Akkapeddi, Padma, Ribeiro, Daniel, Melão, Alice, Barata, João T.   +4 more
openaire   +4 more sources

Trypanosoma cruzi-specific IFN-γ-producing cells in chronic Chagas disease associate with a functional IL-7/IL-7R axis. [PDF]

PLoS Neglected Tropical Diseases, 2018
BackgroundThe severity of cardiac disease in chronic Chagas disease patients is associated with different features of T-cell exhaustion. Here, we assessed whether the ability of T cells to secrete IFN-γ in response to T. cruzi was linked to disruption in
María A Natale, Gonzalo Cesar, María G Alvarez, Melisa D Castro Eiro, Bruno Lococo, Graciela Bertocchi, María C Albareda, Susana A Laucella   +7 more
doaj   +2 more sources

The Expressions of IL-7 and IL-7R and the Relationship between them with Lymph Node Metastasis and Prognosis in Non-small Cell Lung Cancer [PDF]

Chinese Journal of Lung Cancer, 2010
Background and objective It has been proven that lymph node metastasis was closely related to prognosis of lung cancer. Interleukin-7 (IL-7) and interleukin-7 receptor (IL-7R) could promote lymph node metastasis through vascular endothelial growth factor-
Jian MING, Qingfu ZHANG, Yanduo JIANG, Xueshan QIU, Xiaozhong BAI   +4 more
doaj   +1 more source

The Therapeutic Values of IL-7/IL-7R and the Recombinant Derivatives in Glioma: A Narrative Review

Journal of Interferon & Cytokine Research, 2023
Interleukin-7 (IL-7) is essential for maintaining the immune system's defense functions by regulating the development and homeostasis of lymphocytes. Findings have shown the high efficacy of IL-7/IL-7 receptor (IL-7R)-based immunotherapy on various malignancies, with confirmation in both animal models and humans.
Marjan Hesari, Zeinab Attar, Shakiba Soltani-Shirazi, Omid Keshavarzian, Reza Taheri, Reza Tabrizi, Hamed Fouladseresht   +6 more
openaire   +3 more sources