IL-7 Induces an Epitope Masking of γc Protein in IL-7 Receptor Signaling Complex [PDF]
Mediators of Inflammation, 2017 IL-7 signaling via IL-7Rα and common γ-chain (γc) is necessary for the development and homeostasis of T cells. Although the delicate mechanism in which IL-7Rα downregulation allows the homeostasis of T cell with limited IL-7 has been well known, the ...
Tae Sik Goh +11 more
doaj +6 more sources
Cytokine, 2022 IL-7 is a member of the family of cytokines with four anti-parallel α helixes that bind Type I cytokine receptors. It is produced by stromal cells and is required for development and homeostatic survival of lymphoid cells.Interleukin 7 (IL7) human IL7: gene ID: 3574 on ch 8; murine Il7 gene ID: 16,196 on ch 3.Precursor contains a signal sequence ...
Winer H +7 more
openaire +4 more sources
Increased bone marrow interleukin-7 (IL-7)/IL-7R levels but reduced IL-7 responsiveness in HIV-positive patients lacking CD4+ gain on antiviral therapy. [PDF]
PLoS ONE, 2010 BACKGROUND: The bone marrow (BM) cytokine milieu might substantially affect T-lymphocyte homeostasis in HIV-positive individuals. Interleukin-7 (IL-7) is a bone marrow-derived cytokine regulating T-cell homeostasis through a CD4+-driven feedback loop ...
Giusi Maria Bellistrì +9 more
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IL-7-dependent maintenance of ILC3s is required for normal entry of lymphocytes into lymph nodes
, 2021 IL-7 is essential for the development and homeostasis of T and B lymphocytes and is critical for neonatal lymph node organogenesis because Il7-/- mice lack normal lymph nodes.
Natalie Papazian (11282574) +7 more
core +1 more source
Flip the coin: IL-7 and IL-7R in health and disease [PDF]
, 2019 The cytokine IL-7 and its receptor, IL-7R, are critical for T cell and, in the mouse, B cell development, as well as differentiation and survival of naive T cells, and generation and maintenance of memory T cells.
Benedict Seddon +8 more
core +1 more source
Interleukin 7 from maternal milk crosses the intestinal barrier and modulates T-cell development in offspring [PDF]
, 2011 Background Breastfeeding protects against illnesses and death in hazardous environments, an effect partly mediated by improved immune function. One hypothesis suggests that factors within milk supplement the inadequate immune response of the offspring,
Andrew M Prentice +11 more
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Characterization of lymphoid tissue inducer cells and lymphoid tissue development in adult interleukin 7 transgenic mice [PDF]
, 2008 During embryogenesis, the development of secondary lymphoid organs (SLOs) such as lymph nodes (LNs) and Peyer’s patches (PPs) requires the cellular crosstalk between vascular cell adhesion molecule (VCAM)-1+ mesenchymal organizer cells and CD45+CD4 ...
Schmutz, Sandrine
core +1 more source
Cancer Medicine, 2023 Purpose Addressing lymphopenia in cancer patients has been suggested as a novel immunotherapeutic strategy. As interleukin‐7 (IL‐7) is necessary for proliferation of lymphocytes and to increase total lymphocyte count (TLC), IL‐7 therapy has been ...
Stephen Ahn +5 more
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Comparative analysis of the lambda-interferons IL-28A and IL-29 regarding their transcriptome and their antiviral properties against hepatitis C virus. [PDF]
, 2010 Specific differences in signaling and antiviral properties between the different Lambda-interferons, a novel group of interferons composed of IL-28A, IL-28B and IL-29, are currently unknown.
Ralf Bartenschlager +28 more
core +1 more source
Soluble IL-7Rα/sCD127 in Health, Disease, and Its Potential Role as a Therapeutic Agent
ImmunoTargets and Therapy, 2021 Priscila O Barros,1 Tamara K Berthoud,1 Nawaf Aloufi,2 Jonathan B Angel3 1Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; 2Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of ...
Barros PO +3 more
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