Results 41 to 50 of about 69,683,828 (280)

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Trans-endocytosis of intact IL-15Rα–IL-15 complex from presenting cells into NK cells favors signaling for proliferation

, 2019
Interleukin 15 (IL-15) is essential for natural killer (NK) cell survival and proliferation. The IL-15 receptor consists of 3 subunits: the α chain and the β and common γ chains, which are shared with the IL-2 receptor.
Snapp, Erik, Traba, Javier, Long, Eric, Antón Hurtado, Olga María, Rajagopalan, Sumati, Waldmann, Thomas, Hollander, Michael, Arora, Gunjan, Garcia, Christopher, Peterson, Mary, Dorward, David   +10 more
core   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Usage of IFNγ or TNFα-T in protocols for obtaining cytokine-induced killer cells for adoptive immunotherapy

Медицинская иммунология
Methods of immunocorrection based on injection of in vitro activated autologous leukocytes are becoming widespread. Our previous studies suggest that implementation of immunotherapy with in vitro activated lymphocytes using cytokines is effective for the
Yu. V. Gelm, L. Yu. Grivtsova, I. A. Pasova, Т. V. Konstantinova, Т. Yu. Mushkarina, S. A. Ivanov, A. D. Kaprin   +6 more
doaj   +1 more source

IL-12, IL-15, and IL-18 pre-activated NK cells target resistant T cell acute lymphoblastic leukemia and delay leukemia development in vivo

OncoImmunology, 2017
NK cells have shown promise in therapy of hematological cancers, in particular against acute myeloid leukemia. In contrast, the more NK cell-resistant acute lymphoblastic leukemia (ALL) is difficult to treat with NK-cell-based therapies, and we ...
Margherita Boieri, Aina Ulvmoen, Amanda Sudworth, Clare Lendrem, Matthew Collin, Anne M. Dickinson, Lise Kveberg, Marit Inngjerdingen   +7 more
doaj   +1 more source

Towards an automated approach to map flooded areas from Sentinel-2 MSI data and soft integration of water spectral features

International Journal of Applied Earth Observations and Geoinformation, 2020
In this work we propose an approach for mapping flooded areas from Sentinel-2 MSI (Multispectral Instrument) data based on soft fuzzy integration of evidence scores derived from both band combinations (i.e.
Alessia Goffi, Daniela Stroppiana, Pietro Alessandro Brivio, Gloria Bordogna, Mirco Boschetti   +4 more
doaj   +1 more source

Cytokine Gene Vaccine Therapy for Treatment of a Brain Tumor

Brain Sciences, 2023
A glioma is a malignant brain tumor with a poor prognosis. Attempts at the surgical removal of the tumor are the first approach, but additional treatment strategies, including radiation therapy and systemic or local chemotherapy, are necessary ...
Terry Lichtor, Bingtao Tang, Edward J. Roy   +2 more
doaj   +1 more source

Evidence‐Informed Multidisciplinary Consensus Guidance for the Psychosocial Care of Adolescents With High‐Risk Cancer: Recommendations From the Italian Association of Pediatric Hematology and Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adolescents with high‐risk cancer face complex developmental, psychosocial, and ethical challenges that extend beyond disease‐directed treatment. Although international recommendations exist for communication, psychosocial care, pediatric palliative care, survivorship, and shared decision‐making, these have largely evolved within ...
Johanna M. C. Blom, Dorella Scarponi, Giulia Zucchetti, Teresa Perillo, Maria Montanaro, Elisa Marconi, Chiara Rutigliano, Paolo Colavero, Paola Quarello, Marina Bertolotti, Monica Cellini, Carlo Clerici, Maurizio Mascarin, Francesca Bomben, Andrea Ferrari, the expert workgroup   +15 more
wiley   +1 more source

A Study Correlation between Levels IL-15, IL-23 and TNF-α in a Sample of Iraqi Psoriasis Patients

Ibn Al-Haitham Journal for Pure and Applied Sciences
Psoriasis is defined as a series of events that begins in its initial stage with dermatitis and then progresses to more widespread inflammation and increased oxidative stress.
Samara Amar Sabri, Shaima R. Ibraheem
doaj   +1 more source

The Timing and Abundance of IL-2Rβ (CD122) Expression Control Thymic iNKT Cell Generation and NKT1 Subset Differentiation

Frontiers in Immunology, 2021
Invariant NKT (iNKT) cells are thymus-generated innate-like T cells, comprised of three distinct subsets with divergent effector functions. The molecular mechanism that drives the lineage trifurcation of immature iNKT cells into the NKT1, NKT2, and NKT17
Hee Yeun Won, Hye Kyung Kim, Assiatu Crossman, Parirokh Awasthi, Ronald E. Gress, Jung-Hyun Park   +5 more
doaj   +1 more source