A critical role for IL-21/IL-21 receptor signaling in isoproterenol-induced cardiac remodeling [PDF]
Scientific ReportsIncreased cytokine secretion from immune cells is often associated with cardiac remodeling and heart failure due to pressure overload. Several reports suggest that the IL-21/IL-21 receptor (IL-21R) signaling pathway may play a critical role in heart ...
Bing Qi +16 more
doaj +4 more sources
Impact of IL-21 Gene Polymorphisms (rs2055979) and the Levels of Serum IL-21 on the Risk of Multiple Sclerosis [PDF]
Archives of Razi Institute, 2022 Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system. Genetic and environmental factors have important roles in the induction, onset, and progression of MS. In this study, the IL-21 genotype (rs2055979) (G/T) in Iraqi MS
A Ali Abdulla +2 more
doaj +3 more sources
Serum Levels of IL-21 and IL-22 in Breast Cancer Patients—A Preliminary Study [PDF]
Current Issues in Molecular BiologyBreast cancer is one of the most commonly diagnosed malignant tumours in women worldwide. Although modern medicine has led to advanced diagnostic methods and therapies that allow for increasingly effective treatment, the mechanisms underlying breast ...
Jacek Kabut +8 more
doaj +2 more sources
IL-15, IL-18 and IL-21 Along the Stress–Smoking–Periodontal Health Axis: A Cross-Sectional Study in Mexican Adults [PDF]
BiomedicinesFrom a psychoneuroimmunology standpoint, stress and cigarette smoking are plausible modulators of periodontal inflammation through neuroendocrine–immune pathways and cytokine networks. Interleukin-18 (IL-1 family), interleukin-21 (common γ-chain cytokine)
Carmen Celina Alonso-Sánchez +6 more
doaj +2 more sources
IL-21 isoform transgenic mice spontaneously develop mammary tumors: possible involvement of IL-21-induced osteopontin expression in tumorigenesis [PDF]
Frontiers in ImmunologyIntroductionInterleukin-21 (IL-21) is a pleiotropic cytokine produced by CD4+ T cells that critically regulates the differentiation and functions of various adaptive and innate immune cells.
Risako Yamaguchi +10 more
doaj +2 more sources
Aberrant STAT3 activation and overproduction of IL-21 in systemic lupus erythematosus: role of miR-155 and miR-21 in target genes SOCS1, PTEN and PIAS3 [PDF]
Frontiers in ImmunologyIntroductionSLE is a chronic autoimmune disease characterized by immune system dysregulation, including aberrant activation of B and T lymphocytes and overproduction of proinflammatory cytokines such as IL-21.
Noemí Espinoza-García +14 more
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Chronic IL-21 drives neuroinflammation and promotes lipid accumulation in microglia [PDF]
Immunity & AgeingNeuroinflammation is a key contributor to the onset and progression of neurodegenerative diseases, driven by factors such as viral infections, autoimmune disorders, and peripheral inflammation.
Hugo Oyamada +6 more
doaj +2 more sources
Recruitment of plasma cells from IL-21-dependent and IL-21-independent immune reactions to the bone marrow [PDF]
Nature CommunicationsBone marrow plasma cells (BMPC) are the correlate of humoral immunity, consistently releasing antibodies into the bloodstream. It remains unclear if BMPC reflect different activation environments or maturation of their precursors.
Marta Ferreira-Gomes +31 more
doaj +2 more sources
Study on serum TL1A levels and their correlation with Th17 cells, IL-17 and IL-21 in children with Graves’ disease [PDF]
Frontiers in ImmunologyObjectiveTo investigate serum TL1A levels and their correlation with Th17 cells, IL-17, and IL-21 in children with Graves’ disease (GD).MethodsThirty-seven children (12 males and 25 females) aged 9-14 years with newly diagnosed and untreated GD were ...
Lijun Hao +5 more
doaj +2 more sources
Follicular Helper T Cells in Pulmonary Tuberculosis: A Retrospective Study [PDF]
Iranian Journal of Immunology, 2022 Background: Follicular helper T lymphocyte (Tfh) promotes antibody production by B lymphocytes in various diseases, including Pulmonary Tuberculosis (PTB).
Haibai Sun +5 more
doaj +1 more source