Results 1 to 10 of about 61,069,248 (252)
Chinese Medical Journal, 2017 Background: The immunopathologic mechanism underlying dermatomyositis (DM) and polymyositis (PM) remains poorly understood. Many cytokines play a pathogenic role in DM and PM.
Tao Liu +3 more
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Interleukin-21 in Viral Infections [PDF]
International Journal of Molecular Sciences, 2021 Interleukin (IL)-21 is a cytokine that affects the differentiation and function of lymphoid and myeloid cells and regulates both innate and adaptive immune responses. In addition to regulating the immune response to tumor and viral infections, IL-21 also has a profound effect on the development of autoimmune and inflammatory diseases. IL-21 is produced
Hironobu Asao
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Therapeutic potential of interleukin-21 in cancer
Frontiers in ImmunologyInterleukin-21 (IL-21) is an immunostimulatory cytokine which belongs to the common gamma-chain family of cytokines. It plays an import role in the development, differentiation, proliferation, and activation of immune cells, in particular T and natural ...
Gheorghita Isvoranu +1 more
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A structural blueprint for interleukin-21 signal modulation
Cell Reports, 2023 Summary: Interleukin-21 (IL-21) plays a critical role in generating immunological memory by promoting the germinal center reaction, yet clinical use of IL-21 remains challenging because of its pleiotropy and association with autoimmune disease. To better
Gita C. Abhiraman +9 more
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Pathogens, 2022 Protective immunity against blood-stage Plasmodium infection and the disease malaria depends on antibodies secreted from high-affinity B cells selected during the germinal center (GC) response.
Fionna A. Surette, Noah S. Butler
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Evaluation of plasma IL-21 as a potential biomarker for type 1 diabetes progression
Frontiers in Immunology, 2023 IL-21 is a multifunctional cytokine linked with the pathophysiology of several autoimmune diseases, including type 1 diabetes. In this study, our aim was to examine plasma IL-21 levels in individuals at different stages of type 1 diabetes progression. We
Anna-Mari Schroderus +18 more
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Frontiers in Immunology, 2021 ObjectivesMultiple studies suggest that interleukin (IL)-21 plays a pivotal role in the differentiation of B cells and activation of cytotoxic T cells and is involved in the pathogenesis of IgG4-related disease (IgG4-RD).
Mitsuhiro Akiyama +5 more
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Interleukin-21 Influences Glioblastoma Course: Biological Mechanisms and Therapeutic Potential
Cells, 2023 Brain tumors represent a heterogeneous group of neoplasms involving the brain or nearby tissues, affecting populations of all ages with a high incidence worldwide.
Alberto Repici +9 more
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Frontiers in Immunology, 2021 Chronic Hepatitis B (CHB) affects over 350 million people worldwide. Current treatment does result in reduced complications; however, a cure (development of antibodies to the S antigen) is not achieved, requiring life-long therapy.
Arshi Khanam +4 more
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Frontiers in Immunology, 2021 ObjectivesT Follicular helper (Tfh) cells, recognized as a distinct CD4+ T cell subset, mediate the development of long-lived humoral immunity via B cell activation/differentiation. Tfh cells play an important role during hepatic viral infection, but its
Bingying Du +6 more
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