Results 31 to 40 of about 61,069,248 (252)

IL-21 isoform transgenic mice spontaneously develop mammary tumors: possible involvement of IL-21-induced osteopontin expression in tumorigenesis

Frontiers in Immunology
IntroductionInterleukin-21 (IL-21) is a pleiotropic cytokine produced by CD4+ T cells that critically regulates the differentiation and functions of various adaptive and innate immune cells.
Risako Yamaguchi, Risako Yamaguchi, Akemi Araki, Yuji Takeda, Shinichi Saitoh, Junji Yokozawa, Masahiro Yamamoto, Naing Ye Aung, Mitsuru Futakuchi, Satoru Nagase, Hironobu Asao   +10 more
doaj   +1 more source

Expressions of IL-17, IL-21 and IL-23 in the serum of allergic rhinitis patients [PDF]

Journal of Medical Biochemistry, 2011
The present study aimed to investigate the expressions of interleukin-17 (IL-17), IL-21 and IL-23 in the serum of allergic rhinitis (AR) patients and to explore their relationship with special IgE (sFgE) in the serum.
Huang Xuekun, Yang Qintai, Chen Yulian, Peng Li, Zhang Gehua, Yuan Li   +5 more
doaj  

Precocious Interleukin 21 Expression in Naive Mice Identifies a Natural Helper Cell Population in Autoimmune Disease

Cell Reports, 2017
Interleukin 21 (IL-21) plays key roles in humoral immunity and autoimmune diseases. It is known to function in mature CD4+ T follicular B cell helper (TFH) cells, but its potential involvement in early T cell ontogeny is unclear.
Elisabeth A. Marnik, Xulong Wang, Thomas J. Sproule, Giljun Park, Gregory J. Christianson, Sarah Kate Lane-Reticker, Shweta Jain, Theodore Duffy, Hongsheng Wang, Gregory W. Carter, Herbert C. Morse, III, Derry C. Roopenian   +11 more
doaj   +1 more source

Interleukin-21 Signaling: Functions in Cancer and Autoimmunity [PDF]

Clinical Cancer Research, 2007
Abstract Interleukin-21 (IL-21) is a cytokine with structural and sequence homology to IL-2 and IL-15, yet possesses several biological properties distinct from these cytokines. IL-21 is produced mainly by activated CD4+ T cells and natural killer T cells and mediates its activity by binding to the IL-21 receptor (IL-21R), consisting of ...
Davis, Ian D., Skak, Kresten, Smyth, Mark J., Kristjansen, Paul E.G., Miller, Dennis M., Sivakumar, Pallavur V.   +5 more
openaire   +4 more sources

IL-21 impairs pro-inflammatory activity of M1-like macrophages exerting anti-inflammatory effects on rheumatoid arthritis

Autoimmunity, 2022
Objective：Macrophages are the main source of inflammatory mediators and play important roles in the pathogenesis of rheumatoid arthritis (RA). Interleukin-21 (IL-21) regulates both innate and adaptive immune responses and exerts major effects on ...
Leilei Jian, Changhong Li, Xinyu Wang, Lin Sun, Zhenzhen Ma, Jinxia Zhao   +5 more
doaj   +1 more source

Evaluation of Interleukin-21, 23 and 27 mRNA Expression and Protein Level in Liver Transplant Patients

Iranian Journal of Allergy, Asthma and Immunology, 2018
Cytokines have prominent roles in activating of different T cells and shifting the immune response, in this study the role of three cytokines (IL-21, IL-23 and IL-27) is investigated in the liver transplant rejection.
Afsoon Afshari, Ramin Yaghobi, Negar Azarpira, Bita Gerami Zadeh, Seyed Ali Malek Hosseini, Mojtaba Darbouy, Mohammad Hossein Karimi   +6 more
doaj   +1 more source

Plasma interleukin-21 levels and genetic variants are associated with susceptibility to rheumatoid arthritis

BMC Musculoskeletal Disorders, 2021
Background Rheumatoid Arthritis (RA) is a chronic inflammatory condition characterized by autoantibodies development and an elevated spectrum of pro-inflammatory cytokines.
Youguo Hao, Lijun Xie, Jing Xia, Zhen Liu, Baoxiu Yang, Minqin Zhang   +5 more
doaj   +1 more source

Interleukin‐21 in autoimmune and inflammatory skin diseases

European Journal of Immunology, 2023
Abstract Studies on the role of interleukins (ILs) in autoimmune and inflammatory diseases allow for the better understanding of pathologic mechanisms of disease and reshaping of treatment modalities. The development of monoclonal antibodies targeting specific ILs or IL signaling pathways (i.e., anti‐IL‐17/IL‐23 in psoriasis or anti ...
Alberto Mesas‐Fernández, Euna Bodner, Franz Joachim Hilke, Katharina Meier, Kamran Ghoreschi, Farzan Solimani   +5 more
openaire   +2 more sources

Mathematical modeling of interleukin-27 induction of anti-tumor T cells response. [PDF]

, 2014
Interleukin-12 is a pro-inflammatory cytokine which promotes Th1 and cytotoxic T lymphocyte activities, such as Interferon-[Formula: see text] secretion. For this reason Interleukin-12 could be a powerful therapeutic agent for cancer treatment.
Kang-Ling Liao, Xue-Feng Bai, and Avner Friedman, Kang-Ling Liao, Avner Friedman, Xue-Feng Bai (333686), Bai Xue-Feng, Liao Kang-Ling, Xue-Feng Bai, Friedman Avner, Kang-Ling Liao (535938), Avner Friedman (54903)   +9 more
core   +1 more source

Evidence‐Based Clinical Practice Guidelines for the Management of Pediatric Febrile Neutropenia: Resource‐Sensitive Recommendations for the Asian Continent

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Febrile neutropenia (FN) is a frequent and serious complication in children receiving cancer therapy. Standardizing FN management across Asia is challenging due to variable healthcare infrastructure, diagnostic capacity, and infection patterns; however, it could improve resource use and patient outcomes.
Joliza Patricia Cañeba, Shweta Bansal, Tea Reljic, Allyne Montecillo‐Aguelo, Hamidah Alias, Farrah Amaranto, Maria Stella Aquino‐Calingasan, Bambang Ardianto, Eggi Arguni, Sally Blair, Thi Tam Dang, Maria Beatriz Gepte, Samanmalee Gunasekara, Andini Handayani, Miriam Kimpo, Catherine G. Lam, Nawachai Lertvivatpong, Sergio Licona, Ana Loseo, Ratha Mlis, Vivian Moreno Berrio, Nguyen Hoai Anh, Anna Lisa Ong‐Lim, Ha Thu Pham, Krishna Sagar Sharma, Bun Sereyleak, Sally Jane G. Velasco‐Aro, Su Yadana, Ambuj Kumar, Sheena Mukkada   +29 more
wiley   +1 more source