Results 21 to 30 of about 65,138,242 (275)

Differential regulation of interleukin-17 and interferon-y production in inflammatory bowel disease [PDF]

, 2010
PhDBackground and Aims. Interleukin (IL)-17 is now known to be involved in a number of chronic inflammatory disorders. However, the mechanisms regulating its production in inflammatory bowel disease (IBD) are still unclear. Methods.
Rovedatti, Laura
core   +2 more sources

Exploring the association between Th17 pathway gene polymorphisms and pulmonary tuberculosis

Frontiers in Immunology, 2022
Th17 cells play a key role in immunity against Mycobacterium tuberculosis (MTB), and this study aimed to explore the association of Th17 pathway gene polymorphisms with pulmonary tuberculosis (PTB) susceptibility in a Chinese population.
Hong-Miao Li, Hong-Miao Li, Li-Jun Wang, Qian Huang, Hai-Feng Pan, Tian-Ping Zhang   +5 more
doaj   +1 more source

IL-21 and IL-21 receptor in the immunopathogenesis of multiple sclerosis

Journal of Immunotoxicology, 2015
Cytokines are considered important factors in the modulation of various immune responses. Among them, interleukin (IL)-21 is one of the major immune modulators, adjusting various immune responses by affecting various immune cells. It has been suggested that IL-21 may enhance autoimmunity through different mechanisms, such as development and activation ...
Ghalamfarsa, G., Mahmoudi, M., Mohammadnia-Afrouzi, M., Yazdani, Y., Anvari, E., Hadinia, A., Ghanbari, A., Setayesh, M., Yousefi, M., Jadidi-Niaragh, F.   +9 more
openaire   +2 more sources

Interleukin-21 combined with PD-1 or CTLA-4 blockade enhances antitumor immunity in mouse tumor models

OncoImmunology, 2018
Recent advances in cancer treatment with checkpoint blockade of receptors such as CTLA-4 and PD-1 have demonstrated that combinations of agents with complementary immunomodulatory effects have the potential to enhance antitumor activity as compared to ...
Katherine E. Lewis, Mark J. Selby, Gregg Masters, Jose Valle, Gennaro Dito, Wendy R. Curtis, Richard Garcia, Kathy A. Mink, Kimberly S. Waggie, Matthew S. Holdren, Joseph F. Grosso, Alan J. Korman, Maria Jure-Kunkel, Stacey R. Dillon   +13 more
doaj   +1 more source

IL-21 promotes the development of a CD73-positive Vγ9Vδ2 T cell regulatory population

OncoImmunology, 2018
Vγ9Vδ2 T cells contribute to the immune response against many tumor types through their direct cytotoxic activity and capacity to regulate the biological functions of other immune cells, such as dendritic cells and IFN-γ-producing CD8+ T cells.
Clément Barjon, Henri-Alexandre Michaud, Angeline Fages, Cécile Dejou, Alexandre Zampieri, Laetitia They, Aurélie Gennetier, Françoise Sanchez, Laurent Gros, Jean-François Eliaou, Nathalie Bonnefoy, Virginie Lafont   +11 more
doaj   +1 more source

Activation of the FcgammaReceptorIIIa on human natural killer cells leads to increased expression of functional interleukin-21 receptor

OncoImmunology, 2017
Natural killer (NK) cells are innate immune effector cells that play a crucial role in immune surveillance and the destruction of cancer cells. NK cells express a low-affinity receptor for the Fc or constant region of immunoglobulin G (FcγRIIIa) and ...
Elizabeth L. McMichael, Nicholas B. Courtney, Megan C. Duggan, Robert Wesolowski, Dionisia Quiroga, Sri Vidya Kondadasula, Lakhvir S. Atwal, Neela Bhave, Eric Luedke, Alena Cristina Jaime-Ramirez, Amanda R. Campbell, Xiaokui Mo, John C. Byrd, William E. Carson   +13 more
doaj   +1 more source

The biological effects of IL-21 signaling on B-cell mediated responses in organ transplantation

Frontiers in Immunology, 2016
Antibody‐mediated rejection has emerged as one of the major issues limiting the success of organ transplantation. It exerts a highly negative impact on graft function and outcome, and effective treatment is lacking. The triggers for antibody development,
Yongkang Wu, Yongkang Wu, Nicole M van Besouw, Yunying Shi, Martin Johannes Hoogduijn, Lanlan Wang, Carla Baan   +6 more
doaj   +1 more source

Immunobiology of IL-17A in human colorectal cancer [PDF]

, 2015
During the last decade tumor infiltration by immune cells has been recognized as a key factor determining clinical outcome. Whereas the presence within tumor tissues of defined lymphocytic populations, including cytotoxic CD8+ T cells and IFN-gamma ...
Amicarella, Francesca
core   +1 more source

Human CD4+ Memory T Cells Can Become CD4+IL-9+ T Cells [PDF]

, 2010
Background: IL-9 is a growth factor for T- and mast-cells that is secreted by human Th2 cells. We recently reported that IL-4+TGF-β directs mouse CD4+CD25−CD62L+ T cells to commit to inflammatory IL-9 producing CD4+ T cells.
Popoola, Joyce, Wenda Gao, Terry B Strom, Gao Wenda, Strom, Terry B., Strom Terry B., Strom, TB, Putheti, P, Popoola, J, Awasthi, A, Amit Awasthi, Awasthi Amit, Prabhakar Putheti, Popoola Joyce, Awasthi, Amit, Putheti Prabhakar, Joyce Popoola, Gao, W   +17 more
core   +2 more sources

SLAMs Negatively Regulate IL-21 Production in Tfh-Like Cells from Allergic Rhinitis Patients

Journal of Asthma and Allergy, 2021
Jun Yang,1 Lina Geng,2 Yongmin Ma,3 Xinyi Tang,1 Huiyong Peng,1 Jie Tian,2 Huaxi Xu,2 Shengjun Wang1,2 1Department of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, People’s Republic of China; 2Institute
Yang J, Geng L, Ma Y, Tang X, Peng H, Tian J, Xu H, Wang S   +7 more
doaj