Results 11 to 20 of about 65,138,242 (275)
Role of IL-21 and IL-21 Receptor on B Cells in HIV Infection [PDF]
Critical Reviews in Immunology, 2012 Interleukin (IL)-21 is a member of a family of cytokines that includes IL-2, IL-4, IL-7, IL-9, and IL-15, all of which utilize a common γ chain in their individual receptor complexes for delivering intracellular signals in their target cells. IL-21 is produced by CD4+ T-cells, in particular follicular T-helper cells, and is critically important in the ...
Suresh, Pallikkuth +2 more
core +7 more sources
IL-21 and IL-21 Receptor Expression in Lymphocytes and Neurons in Multiple Sclerosis Brain
The American Journal of Pathology, 2011 IL-17-producing CD4(+) T cells (Th-17) contribute to the pathogenesis of experimental autoimmune encephalomyelitis and are associated with active disease in multiple sclerosis (MS). In addition to IL-17, Th-17 cells can also express IL-21, IL-22, and IL-6 under Th-17-polarizing conditions (IL-6 and transforming growth factor-β).
Tzartos, John S +6 more
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TGF-β enhanced IL-21-induced differentiation of human IL-21-producing CD4+ T cells via Smad3. [PDF]
PLoS ONE, 2013 IL-21 has pleiotropic effects on innate and adaptive immune response, and plays an important role in the development of autoimmune disease and antitumor activity. It has been reported that IL-21 is produced by CD4(+) T cells and NKT cells.
Yun Liu +7 more
doaj +2 more sources
IL-21: The Future of Medicine [PDF]
Journal of Clinical and Diagnostic Research, 2017 Interleukin-21 (IL-21), a T- cell-derived cytokine, is a signaling molecule secreted by a subpopulation of T cells called follicular T helper (Tfh) cells.
Syed Raza Shah +5 more
doaj +3 more sources
IL-21 Receptor Expression in Human Tendinopathy [PDF]
Mediators of Inflammation, 2014 The pathogenetic mechanisms underlying tendinopathy remain unclear, with much debate as to whether inflammation or degradation has the prominent role. Increasing evidence points toward an early inflammatory infiltrate and associated inflammatory cytokine
Abigail L. Campbell +8 more
doaj +4 more sources
Pifu-xingbing zhenliaoxue zazhi, 2021 Objective: To explore the immune mechanism of syphilitic sero-fixation by measuring the expression levels of serum IL-17 and IL-21 in syphilis patients with positive serological test.
Rong ZHANG +7 more
doaj +1 more source
Pathogens and Immunity, 2020 The frequency and functions of Th17-polarized CCR6+RORyt+CD4+ T cells are rapidly compromised upon HIV infection and are not restored with long-term viral suppressive antiretroviral therapy (ART).
Delphine Planas +15 more
doaj +1 more source
RNA Sensing of Mycobacterium tuberculosis and Its Impact on TB Vaccination Strategies
Vaccines, 2020 Tuberculosis (TB) is still an important global threat and although the causing organism has been discovered long ago, effective prevention strategies are lacking.
Sanne Burkert, Ralf R. Schumann
doaj +1 more source
Diagnostics, 2023 Interleukins are considered to be potential therapeutic targets that can alter the prognosis and disease progression of IBD. IL-21 has proven to be involved in effector Th1, Th2 and Th17 responses.
Alexandros Toskas +5 more
doaj +1 more source
IL-21 Signaling in Immunity [PDF]
F1000Research, 2016 IL-21 is a type I cytokine produced by T cells and natural killer T cells that has pleiotropic actions on a wide range of immune and non-immune cell types. Since its discovery in 2000, extensive studies on the biological actions of IL-21 have been performed in vitro and in
Warren J. Leonard, Chi-Keung Wan
openaire +2 more sources