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IL-22 in Atopic Dermatitis [PDF]
CellsAtopic dermatitis (AD) is a prevalent and chronic inflammatory skin condition characterized by a multifaceted pathophysiology that gives rise to diverse clinical manifestations.
Julia Laska +4 more
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IL-22 Binding Protein (IL-22BP) in the Regulation of IL-22 Biology [PDF]
Frontiers in Immunology, 2021 Cytokines are powerful mediators of inflammation. Consequently, their potency is regulated in many ways to protect the host. Several cytokines, including IL-22, have coordinating binding proteins or soluble receptors that bind to the cytokine, block the ...
Lauren A. Zenewicz
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Microbiota-Dependent Effects of IL-22 [PDF]
Cells, 2020 Cytokines are important contributors to immune responses against microbial and environmental threats and are of particular importance at epithelial barriers. These interfaces are continuously exposed to external factors and thus require immune components
Morsal Sabihi +3 more
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The AhR/IL-22 axis in chronic gut inflammation: unraveling mechanisms and therapeutic prospects [PDF]
Frontiers in ImmunologyChronic inflammatory bowel diseases, including Crohn’s disease (CD), ulcerative colitis (UC), and post-infectious irritable bowel syndrome (PI-IBS), are characterized by immune-mediated intestinal inflammation and epithelial barrier dysfunction. Research
Huimin Kang +4 more
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IL-22: Immunity's bittersweet symphony. [PDF]
J Exp Med, 2023 Epithelial cells play a crucial role in barrier defense. Here, Moniruzzaman et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20230106) discovered that interleukin-22 (IL-22) represses MHC class II expression by epithelial cells with an opposite impact on chronic inflammatory disease and viral infection.
Duan J, Matute JD, Blumberg RS.
europepmc +3 more sources
Serum Levels of IL-21 and IL-22 in Breast Cancer Patients—A Preliminary Study [PDF]
Current Issues in Molecular BiologyBreast cancer is one of the most commonly diagnosed malignant tumours in women worldwide. Although modern medicine has led to advanced diagnostic methods and therapies that allow for increasingly effective treatment, the mechanisms underlying breast ...
Jacek Kabut +8 more
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Characterization of IL-22 Bioactivity and IL-22-Positive Cells in Grass Carp Ctenopharyngodon idella [PDF]
Frontiers in Immunology, 2020 Interleukin (IL)-22 plays an important role in regulating inflammation and clearance of infectious pathogens. IL-22 homologs have been discovered in fish, but the functions and sources of IL-22 have not been fully characterized.
Yibin Yang +27 more
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IL-22 Binding Protein Controls IL-22-Driven Bleomycin-Induced Lung Injury. [PDF]
Am J PatholThe high mortality rates of acute lung injury and acute respiratory distress syndrome challenge the field to identify biomarkers and factors that can be exploited for therapeutic approaches. IL-22 is a cytokine that has antibacterial and reparative properties in the lung.
Zhang Z +6 more
europepmc +3 more sources
Knowledge mapping and research trends of IL-22 from 2014 to 2023: A bibliometric analysis [PDF]
Human Vaccines & ImmunotherapeuticsAlthough IL-22 has been extensively studied, a comprehensive and systematic bibliometric analysis has not yet been conducted on it. This article reviews the research progress of IL-22 using bibliometric methods.
Shu-Zhen Liu +3 more
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Evaluation of serum levels of interleukins 6, 8, 17 and 22 in acne vulgaris: A cross-sectional study
Indian Journal of Dermatology, 2023 Background: Acne vulgaris (AV) is a chronic, multifactorial, inflammatory skin disease, and it is now becoming increasingly clear that the inflammatory pathway is involved at a very early in the pathogenesis of acne.
Sweta Singh +2 more
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