IL-22 in Atopic Dermatitis [PDF]
CellsAtopic dermatitis (AD) is a prevalent and chronic inflammatory skin condition characterized by a multifaceted pathophysiology that gives rise to diverse clinical manifestations.
Julia Laska +4 more
doaj +4 more sources
IL-22 Binding Protein (IL-22BP) in the Regulation of IL-22 Biology [PDF]
Frontiers in Immunology, 2021 Cytokines are powerful mediators of inflammation. Consequently, their potency is regulated in many ways to protect the host. Several cytokines, including IL-22, have coordinating binding proteins or soluble receptors that bind to the cytokine, block the ...
Lauren A. Zenewicz
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Microbiota-Dependent Effects of IL-22 [PDF]
Cells, 2020 Cytokines are important contributors to immune responses against microbial and environmental threats and are of particular importance at epithelial barriers. These interfaces are continuously exposed to external factors and thus require immune components
Morsal Sabihi +3 more
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The AhR/IL-22 axis in chronic gut inflammation: unraveling mechanisms and therapeutic prospects [PDF]
Frontiers in ImmunologyChronic inflammatory bowel diseases, including Crohn’s disease (CD), ulcerative colitis (UC), and post-infectious irritable bowel syndrome (PI-IBS), are characterized by immune-mediated intestinal inflammation and epithelial barrier dysfunction. Research
Huimin Kang +4 more
doaj +2 more sources
Serum Levels of IL-21 and IL-22 in Breast Cancer Patients—A Preliminary Study [PDF]
Current Issues in Molecular BiologyBreast cancer is one of the most commonly diagnosed malignant tumours in women worldwide. Although modern medicine has led to advanced diagnostic methods and therapies that allow for increasingly effective treatment, the mechanisms underlying breast ...
Jacek Kabut +8 more
doaj +2 more sources
Characterization of IL-22 Bioactivity and IL-22-Positive Cells in Grass Carp Ctenopharyngodon idella [PDF]
Frontiers in Immunology, 2020 Interleukin (IL)-22 plays an important role in regulating inflammation and clearance of infectious pathogens. IL-22 homologs have been discovered in fish, but the functions and sources of IL-22 have not been fully characterized.
Yibin Yang +27 more
doaj +3 more sources
Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of Pregnancy [PDF]
International Journal of Molecular Sciences, 2019 Trophoblast expressing paternal HLA-C resembles a semiallograft, and could be rejected by maternal T cells. IL-22 seems to be involved in allograft rejection and thus could be responsible for miscarriages. We examined the role of decidual IL-22-producing CD4+ T on human pregnancy.
Logiodice F. +6 more
openaire +9 more sources
Serum Levels of IL-22 and ACPA in Patients with Rheumatoid Arthritis [PDF]
Journal of Pure and Applied Microbiology, 2018 Both rheumatoid arthritis and periodontitis are complex multifactorial disorders, characterized not only by a dysfunction of basic inflammatory and tissue destructive mechanisms, but also by an altered adaptive and innate immune response in individuals ...
Zainab A. Aldhaher +2 more
doaj +2 more sources
Crystal structure of the IL‐22/IL‐22R1 complex and its implications for the IL‐22 signaling mechanism [PDF]
FEBS Letters, 2008 MINT‐6693956: Il22 (uniprotkb:Q9GZX6) and IL22R1 (uniprotkb:Q8N6P7) bind (MI:0407) by X-ray crystallography (MI:0114)
Bleicher, Lucas +6 more
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Knowledge mapping and research trends of IL-22 from 2014 to 2023: A bibliometric analysis [PDF]
Human Vaccines & ImmunotherapeuticsAlthough IL-22 has been extensively studied, a comprehensive and systematic bibliometric analysis has not yet been conducted on it. This article reviews the research progress of IL-22 using bibliometric methods.
Shu-Zhen Liu +3 more
doaj +2 more sources