Results 21 to 30 of about 6,541,017 (281)

Interleukin (IL)-25 suppresses IL-22-induced osteoclastogenesis in rheumatoid arthritis via STAT3 and p38 MAPK/IκBα pathway

Arthritis Research & Therapy, 2020
Background The present study aimed to evaluate the suppressive role of interleukin (IL)-25 in IL-22-induced osteoclastogenesis and receptor activator of nuclear factor κB ligand (RANKL) expression in rheumatoid arthritis (RA). Methods Serum from patients
Hong Ki Min, Ji-Yeon Won, Bo-Mi Kim, Kyung-Ann Lee, Seoung-Joon Lee, Sang-Heon Lee, Hae-Rim Kim, Kyoung-Woon Kim   +7 more
doaj   +1 more source

Pro-inflammatory signaling by IL-10 and IL-22: bad habit stirred up by interferons? [PDF]

, 2013
Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share characteristic properties such as defined structural features, usage of IL-10R2 as one receptor chain, and activation of signal transducer and activator of ...
Heiko Mühl, Heiko eMühl, Mühl, Heiko
core   +1 more source

CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis

OncoImmunology, 2023
Metastasis is a cancer-related systemic disease and is responsible for the greatest mortality rate among cancer patients. Interestingly, the interaction between the immune system and cancer cells seems to play a key role in metastasis formation in the ...
Tao Zhang, Ramez Wahib, Dimitra E. Zazara, Jöran Lücke, Ahmad Mustafa Shiri, Jan Kempski, Lilan Zhao, Theodora Agalioti, Andres Pablo Machicote, Olympia Giannou, Ioannis Belios, Rongrong Jia, Siwen Zhang, Joseph Tintelnot, Hannes Seese, Julia Kristin Grass, Baris Mercanoglu, Louisa Stern, Pasquale Scognamiglio, Mohammad Fard-Aghaie, Philipp Seeger, Jonas Wakker, Marius Kemper, Benjamin Brunswig, Anna Duprée, Panagis M. Lykoudis, Anastasia Pikouli, Emmanouil Giorgakis, Pablo Stringa, Natalia Lausada, Maria Virginia Gentilini, Gabriel E. Gondolesi, Kai Bachmann, Philipp Busch, Rainer Grotelüschen, Ioannis C. Maroulis, Petra C. Arck, Ryosuke Nakano, Angus W. Thomson, Tarik Ghadban, Michael Tachezy, Nathaniel Melling, Eike-Gert Achilles, Victor G. Puelles, Felix Nickel, Thilo Hackert, Oliver Mann, Jakob R. Izbicki, Jun Li, Nicola Gagliani, Samuel Huber, Anastasios D. Giannou   +51 more
doaj   +1 more source

AAV-IL-22 modifies liver chemokine activity and ameliorates portal inflammation in murine autoimmune cholangitis [PDF]

, 2017
There remain significant obstacles in developing biologics to treat primary biliary cholangitis (PBC). Although a number of agents have been studied both in murine models and human patients, the results have been relatively disappointing.
莊雅惠, Hsueh, Yu-Hsin;Chang, Yun-Ning;Loh, Chia -En;Gershwin, M. Eric;Chuang, Ya-Hui   +1 more
core   +1 more source

IL-22 mediates goblet cell hyperplasia and worm expulsion in intestinal helminth infection. [PDF]

, 2013
Type 2 immune responses are essential in protection against intestinal helminth infections. In this study we show that IL-22, a cytokine important in defence against bacterial infections in the intestinal tract, is also a critical mediator of anti ...
Stockinger, Brigitta, Helmby, Helena, Brigitta Stockinger, Helmby Helena, Turner, Jan-Eric, Helena Helmby, Turner Jan-Eric, Stockinger Brigitta, Jan-Eric Turner   +8 more
core   +1 more source

Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and interleukin-1 [PDF]

, 2010
If insufficiently treated, Lyme borreliosis can evolve into an inflammatory disorder affecting skin, joints, and the CNS. Early innate immunity may determine host responses targeting infection. Thus, we sought to characterize the immediate cytokine storm
Nicole Darsow, Kind, Peter, Rudloff, Ina, Klaus-Peter Hunfeld, Katharina Horn, Itamar Goren, Urs Christen, Kraiczy Peter, Horn Katharina, Pfeilschifter, Josef (Prof. Dr.), Mühl Heiko, Koehl Ulrike, Peter Kind, Goren Itamar, Pfeilschifter, Josef, Peter Kraiczy, Rudloff Ina, Goren, Itamar, Mühl, Heiko, Darsow, Nicole, Christen Urs, Kraiczy, Peter, Christen, Urs, Holdener, Martin, Horn, Katharina, Hunfeld, Klaus-Peter, Ulrike Koehl, Hunfeld Klaus-Peter, Heiko Mühl, Ina Rudloff, Malte Bachmann, Martin Holdener, Holdener Martin, Koehl, Ulricke, Bachmann Malte, Darsow Nicole, Kind Peter, Köhl, Ulrike, Josef Pfeilschifter, Bachmann, Malte, Pfeilschifter Josef   +40 more
core   +1 more source

Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study [PDF]

, 2012
Background: Interleukin-22 (IL-22), recently identified as a crucial parameter of pathology in experimental liver damage, may determine survival in clinical end-stage liver disease.
Stefan Zeuzem, Herrmann, Eva, Oliver Waidmann, Kronenberger, Bernd, Friederike Brunner, Rudloff, Ina, Bernd Kronenberger, Waidmann, Oliver, Albrecht Piiper, Pfeilschifter, Josef (Prof. Dr.), Piiper, Albrecht, Heiko Mühl, Filmann, Natalie, Ina Rudloff, Malte Bachmann, Eva Herrmann, Josef Pfeilschifter, Lisa Kapper, Bachmann, Malte, Brunner, Friederike, Kapper, Lisa, Mühl, Heiko, Natalie Filmann, Zeuzem, Stefan   +23 more
core   +1 more source

Recent advances in IL-22 biology [PDF]

International Immunology, 2011
Several cell types, in particular epithelial cells, express the receptor for the cytokine IL-22 and upon its recognition produce molecules that are active both locally and systemically. Many different types of lymphocyte secrete IL-22. T(h)17 cells produce IL-22 although the optimal conditions for secretion of IL-17 or IL-22 by T(h)17 cells differ, as ...
Lauren A, Zenewicz, Richard A, Flavell
openaire   +2 more sources

ES-62 protects against collagen-induced arthritis by resetting interleukin-22 towards resolution of inflammation in the joints [PDF]

, 2014
Objective. The parasitic worm–derived immunomodulator ES-62 protects against disease in the mouse collagen-induced arthritis (CIA) model of rheumatoid arthritis (RA) by suppressing pathogenic interleukin-17 (IL-17) responses. The Th17 associated cytokine
Al-Riyami, Lamyaa, Pineda, Miguel A, Rodgers, David T, Harnett, Margaret M., Harnett, Margaret, Miguel A. Pineda, Lamyaa Al‐Riyami, Harnett, William, Rodgers, David T., David T. Rodgers, Margaret M. Harnett, Pineda, Miguel A., William Harnett   +12 more
core   +1 more source

Elevated interleukin-10, -22, -24, and -26 in serum samples of children with infectious mononucleosis [PDF]

Journal of Medical Biochemistry
Background: Infectious mononucleosis (IM) is an infectious disease with different stages of onset, and the pathogenesis of IM remains unclear. This study aimed to investigate the levels of interleukin (IL)-10 family cytokines IL-10, -22, -24, and -26 in ...
Li Dalei, Mao Kangwei, Luo Peiliang, Zheng Ziqiang, Liu Jiangyan, Zhang Chenxi, Gu Siyu, Zhang Rui, Sun Jun, Wang Juan   +9 more
doaj   +1 more source