Role of Th22 Cells in the Pathogenesis of Autoimmune Diseases [PDF]
Frontiers in Immunology, 2021 Upon antigenic stimulation, naïve CD4+T cells differentiate into different subsets and secrete various cytokines to exert biological effects. Th22 cells, a newly identified CD4+T cell subset,are distinct from the Th1, Th2 and Th17 subsets.
Shengjun Wang, Lu L, Fan Xiao
exaly +7 more sources
Current Knowledge of Th22 Cell and IL-22 Functions in Infectious Diseases [PDF]
Pathogens, 2023 T helper 22 (Th22) cells, a newly defined CD4+ T-cell lineage, are characterized by their distinct cytokine profile, which primarily consists of IL-13, IL-22 and TNF-α.
Chaozhao Liang, Meng Zhang
exaly +6 more sources
Th22 cells and the intestinal mucosal barrier
Frontiers in Immunology, 2023 T-helper 22 (Th22) cells represent a novel subset of CD4+ T cells that exhibit distinctive characteristics, namely the secretion of IL-22 while abstaining from secreting IL-17 and interferon-γ (IFN-γ).
Jieli Chen, Jun Yao
exaly +5 more sources
Role of Th22 and IL-22 in pathogenesis of allergic airway diseases: Pro-inflammatory or anti-inflammatory effect? [PDF]
Pediatrics and Neonatology, 2018 A new population of T cells known as Th22 was described for the first time in 2009. These cells are usually identified by the production of IL-22. However, this cytokine is also secreted by other cells such as Th1, Th2, Th17, natural killers, and innate ...
Brigita Gradauskiene +1 more
exaly +4 more sources
Role of Th22 Cells in Human Viral Diseases [PDF]
Frontiers in Medicine, 2021 Naive CD4+ T cells can differentiate into different cell subsets after receiving antigen stimulation, which secrete corresponding characteristic cytokines and thereby exert biological effects in various diseases.
Jue Xie, Cui Dawei
exaly +5 more sources
Elevated profiles of peripheral Th22, Th17, Th2 cells, and decreased percentage of Th1 cells in breast cancer patients [PDF]
Thoracic Cancer, 2023 Background Th22 subset is a particular type of CD4+ T helper cells subset. Our study aimed to explore the expression level of circulating Th22, Th17, Th1, and Th2 cells and the possible mechanism of these cells in breast cancer (BC) with different ...
Zhiguo Peng +9 more
doaj +2 more sources
HIV impairs and exploits pulmonary Th17 and Th22 cell-mediated immune responses to Mycobacterium tuberculosis. [PDF]
PLoS PathogensTuberculosis (TB) kills an estimated 1.25 million people annually and is the leading cause of death in people with HIV (PWH) (1). The CD4+ T helper (Th) populations play significant roles in protective immunity to Mycobacterium tuberculosis (Mtb) and are
Yazmin B Martinez-Martinez +9 more
doaj +2 more sources
Th22 Cells Promote Osteoclast Differentiation via Production of IL-22 in Rheumatoid Arthritis
Frontiers in Immunology, 2018 T helper (Th) cells can differentiate into functionally distinct subsets and play a pivotal role in inflammatory and autoimmune diseases such as rheumatoid arthritis (RA).
, Gulzhan Trimova, Satoshi Kubo
exaly +3 more sources
Repertoire-based mapping and time-tracking of T helper cell subsets in scRNA-Seq [PDF]
Frontiers in ImmunologyIntroductionThe functional programs of CD4+ T helper (Th) cell clones play a central role in shaping immune responses to different challenges. While advances in single-cell RNA sequencing (scRNA-Seq) have significantly improved our understanding of the ...
Daniil K. Lukyanov +25 more
doaj +2 more sources
The Role of T Helper 22 Cells in Dermatological Disorders
Frontiers in Immunology, 2022 T helper 22 (Th22) cells are a newly identified subset of CD4+ T cells that secrete the effector cytokine interleukin 22 (IL-22) upon specific antigen stimulation, barely with IFN-γ or IL-17. Increasing studies have demonstrated that Th22 cells and IL-22
Yu Pan +12 more
doaj +1 more source