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Current Knowledge of Th22 Cell and IL-22 Functions in Infectious Diseases
Pathogens, 2023 T helper 22 (Th22) cells, a newly defined CD4+ T-cell lineage, are characterized by their distinct cytokine profile, which primarily consists of IL-13, IL-22 and TNF-α.
Chaozhao Liang, Meng Zhang
exaly +6 more sources
Role of Th22 Cells in the Pathogenesis of Autoimmune Diseases [PDF]
Frontiers in Immunology, 2021 Upon antigenic stimulation, naïve CD4+T cells differentiate into different subsets and secrete various cytokines to exert biological effects. Th22 cells, a newly identified CD4+T cell subset,are distinct from the Th1, Th2 and Th17 subsets.
Shengjun Wang, Jue Xie, Liwei Lu
exaly +7 more sources
Th22 cells and the intestinal mucosal barrier
Frontiers in Immunology, 2023 T-helper 22 (Th22) cells represent a novel subset of CD4+ T cells that exhibit distinctive characteristics, namely the secretion of IL-22 while abstaining from secreting IL-17 and interferon-γ (IFN-γ).
Jieli Chen, Jun Yao
exaly +5 more sources
Pediatrics and Neonatology, 2018 A new population of T cells known as Th22 was described for the first time in 2009. These cells are usually identified by the production of IL-22. However, this cytokine is also secreted by other cells such as Th1, Th2, Th17, natural killers, and innate ...
Brigita Gradauskiene +1 more
exaly +4 more sources
Increased circulating Th22 cells correlated with Th17 cells in patients with severe preeclampsia
Hypertension in Pregnancy, 2017 Objective: We aimed to investigate Th22 cells and their association with Th17 and Treg cells in the etiology of severe preeclampsia (sPE). Methods: Thirty sPE patients and 30 healthy pregnant women were recruited in this study.
Zhan Zhang, Ying Shi, Yuanyuan Wang
exaly +3 more sources
Thoracic Cancer, 2023 Background Th22 subset is a particular type of CD4+ T helper cells subset. Our study aimed to explore the expression level of circulating Th22, Th17, Th1, and Th2 cells and the possible mechanism of these cells in breast cancer (BC) with different ...
Zhiguo Peng +9 more
doaj +2 more sources
The NOTCH-HES-1 axis is involved in promoting Th22 cell differentiation [PDF]
Cellular & Molecular Biology Letters, 2021 Background NOTCH signaling has been shown to play a role in the production of interleukin-22 (IL-22) by CD4+ T cells. Multiple T-helper (Th) cell populations secrete IL-22.
Chong Zeng +7 more
doaj +3 more sources
HIV impairs and exploits pulmonary Th17 and Th22 cell-mediated immune responses to Mycobacterium tuberculosis. [PDF]
PLoS PathogensTuberculosis (TB) kills an estimated 1.25 million people annually and is the leading cause of death in people with HIV (PWH) (1). The CD4+ T helper (Th) populations play significant roles in protective immunity to Mycobacterium tuberculosis (Mtb) and are
Yazmin B Martinez-Martinez +9 more
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The Role of T Helper 22 Cells in Dermatological Disorders
Frontiers in Immunology, 2022 T helper 22 (Th22) cells are a newly identified subset of CD4+ T cells that secrete the effector cytokine interleukin 22 (IL-22) upon specific antigen stimulation, barely with IFN-γ or IL-17. Increasing studies have demonstrated that Th22 cells and IL-22
Yu Pan +12 more
doaj +1 more source
Медицинская иммунология, 2014 . T cell populations, specifically, T helper (Th) cells, are among key players in the processes occurring in the body following exposure to a foreign antigen. Usage of new, highly sensitive instruments allowed of more detailed studies of their structural
S. V. Khaidukov
doaj +1 more source