Results 31 to 40 of about 8,035 (194)

Circulating Th17, Th22, and Th1 Cells Are Increased in Psoriasis [PDF]

Journal of Investigative Dermatology, 2010
Th17, Th22, and Th1 cells are detected in psoriatic skin lesions and implicated in psoriasis pathogenesis, but inflammatory T cell numbers in blood, as well as the relative importance of each cell type, is unclear. Using 7-color flow cytometry, circulating Th17, Th22, and Th1 cells were quantified in 21 untreated psoriatics and 17 healthy individuals ...
Kagami, Shinji, Rizzo, Heather L., Lee, Jennifer J., Koguchi, Yoshinobu, Blauvelt, Andrew   +4 more
openaire   +2 more sources

Importance of Th22 Cell Disequilibrium in Immune Thrombocytopenic Purpura [PDF]

Medical Science Monitor, 2018
BACKGROUND The disequilibrium of T helper (Th) cells play an important role in the occurrence and development of immune thrombocytopenic purpura (ITP). Th22 cells, as a newly discovered subset of T lymphocytes, plays an important role in autoimmune disorders and inflammatory diseases.
Zhan, Feng-xia, Li, Juan, Fang, Min, Ding, Juan, Wang, Qian   +4 more
openaire   +2 more sources

Th22 Cells/IL-22 Serves as a Protumor Regulator to Drive Poor Prognosis through the JAK-STAT3/MAPK/AKT Signaling Pathway in Non-Small-Cell Lung Cancer

Journal of Immunology Research, 2022
The interaction of immune cells and cytokines in the tumor microenvironment affects the development and prognosis of tumors with an unclear potential regulatory mechanism.
Yinan Yao, Guangdie Yang, Guohua Lu, Jiani Ye, Luyun Cui, Zhu Zeng, Junjun Chen, Jianying Zhou   +7 more
doaj   +1 more source

The clinical significance of intrahepatic Th22 cells in liver cirrhosis [PDF]

Advances in Clinical and Experimental Medicine, 2019
Th22 cells are a recently identified CD4+ T helper subset and have been implicated in the pathogenesis of certain diseases in humans, but the role of Th22 cells in liver cirrhosis (LC) remains unclear.The aim of the study was to investigate the expression and clinical significance of intrahepatic Th22 cells in LC tissues.Samples of liver tissue of 20 ...
Shanyu, Qin, Mei, Chen, Xiaoyun, Guo, Wei, Luo, Jiaxu, Wang, Haixing, Jiang   +5 more
openaire   +2 more sources

Acteoside relieves mesangial cell injury by regulating Th22 cell chemotaxis and proliferation in IgA nephropathy

Renal Failure, 2018
The existing therapies of IgA nephropathy are unsatisfying. Acteoside, the main component of Rehmannia glutinosa with anti-inflammatory and anti-immune effects, can improve urinary protein excretion and immune disorder.
Lu Gan, Xiaozhao Li, Mengyuan Zhu, Chen Chen, Huimin Luo, Qiaoling Zhou   +5 more
doaj   +1 more source

Th22 cells are expanded in multiple sclerosis and are resistant to IFN-β [PDF]

Journal of Leukocyte Biology, 2014
AbstractTh1 and Th17 cells have been considered as effectors in mouse EAE and in the human counterpart, MS. Recently, IL-22, a Th17-related, proinflammatory cytokine, has been associated with a new Th cell subset, defined as Th22, involved in chronic inflammatory conditions, such as psoriasis; the role of IL-22 in MS has not yet been elucidated.
ROLLA, SIMONA, BARDINA, VALENTINA, DE MERCANTI, STEFANIA FEDERICA, QUAGLINO, Pietro, R. De Palma, D. Gned, D. Brusa, DURELLI, Luca, NOVELLI, Francesco, CLERICO, Marinella   +9 more
openaire   +4 more sources

Levels of Pathogenic Th17 and Th22 Cells in Patients with Rheumatoid Arthritis

Journal of Immunology Research, 2022
Rheumatoid arthritis (RA) is a chronic autoimmune condition characterized, among others, by tissue damage and activation/differentiation of proinflammatory lymphocytes. Accordingly, several studies have concluded that type 17 T helper (Th17) cells seem to have an important role in the pathogenesis of this condition.
Marlen Vitales-Noyola, Berenice Hernández-Castro, Diana Alvarado-Hernández, Lourdes Baranda, Sofía Bernal-Silva, Carlos Abud-Mendoza, Perla Niño-Moreno, Roberto González-Amaro   +7 more
openaire   +3 more sources

Huangkui Capsule in Combination with Leflunomide Improves Immunoglobulin A Nephropathy by Inhibiting the TGF-β1/Smad3 Signaling Pathway

Clinics, 2021
OBJECTIVES: To investigate the efficacy and potential molecular mechanism of Huangkui capsule in combination with leflunomide (HKL) for the treatment of immunoglobulin A nephropathy (IgAN) METHODS: IgAN rat models were constructed by treating rats with ...
Shuwen Pei, Yan Li
doaj   +1 more source

Increased differentiation of Th22 cells in Hashimoto^|^rsquo;s thyroiditis

Endocrine Journal, 2014
As Th22 subsets are identified, their involvement in the pathogenesis of numerous autoimmune diseases has become apparent. In this study, we investigated differentiation of Th22 cells in the autoimmune thyroid diseases including Hashimoto's thyroiditis (HT) and Graves' disease (GD).
Bai, Xue, Sun, Jie, Wang, Weiwei, Shan, Zhongyan, Zheng, Hongzhi, Li, Yushu, Zhao, Yuhang, Gong, Ming, Teng, Weiping   +8 more
openaire   +3 more sources

Increased Expressions of IL-22 and Th22 cells in the coxsackievirus B3-Induced mice acute viral myocarditis

Virology Journal, 2012
Background Recently, a new subset of T helper (Th) cell that predominantly secret cytokine interleukin-22 (IL-22) is identified, termed Th22 cells. The Th22 subset has been demonstrated to be involved in immunity and tissue inflammation.
Kong Qing, Wu Weifeng, Yang Fan, Liu Yanli, Xue Yimin, Gao Mengsha, Lai Wenyin, Pan Xiaofen, Yan Yuluan, Pang Yu, Deng Yuanhua   +10 more
doaj   +1 more source