Role of Th22 Cells in the Pathogenesis of Autoimmune Diseases [PDF]
Frontiers in Immunology, 2021 Upon antigenic stimulation, naïve CD4+T cells differentiate into different subsets and secrete various cytokines to exert biological effects. Th22 cells, a newly identified CD4+T cell subset,are distinct from the Th1, Th2 and Th17 subsets.
Qi Jiang +7 more
doaj +9 more sources
Th22 cells and the intestinal mucosal barrier [PDF]
Frontiers in Immunology, 2023 T-helper 22 (Th22) cells represent a novel subset of CD4+ T cells that exhibit distinctive characteristics, namely the secretion of IL-22 while abstaining from secreting IL-17 and interferon-γ (IFN-γ).
Jieli Chen, Jun Yao
doaj +6 more sources
Current Knowledge of Th22 Cell and IL-22 Functions in Infectious Diseases
Pathogens, 2023 T helper 22 (Th22) cells, a newly defined CD4+ T-cell lineage, are characterized by their distinct cytokine profile, which primarily consists of IL-13, IL-22 and TNF-α.
Kunyu Zhang +4 more
doaj +6 more sources
Role of Th22 Cells in Human Viral Diseases [PDF]
Frontiers in Medicine, 2021 Naive CD4+ T cells can differentiate into different cell subsets after receiving antigen stimulation, which secrete corresponding characteristic cytokines and thereby exert biological effects in various diseases.
Jianguang Gong +5 more
doaj +5 more sources
The Imbalance between Foxp3+Tregs and Th1/Th17/Th22 Cells in Patients with Newly Diagnosed Autoimmune Hepatitis [PDF]
Journal of Immunology Research, 2018 This study is aimed at examining the potential role of regulatory T- (Treg-) Th1-Th17-Th22 cells in the pathogenic process of autoimmune hepatitis (AIH). The numbers of Foxp3+Tregs and Th1, Th17, and Th22 cells were measured in 32 AIH patients using flow
Ma Liang +4 more
doaj +3 more sources
Thoracic Cancer, 2023 Background Th22 subset is a particular type of CD4+ T helper cells subset. Our study aimed to explore the expression level of circulating Th22, Th17, Th1, and Th2 cells and the possible mechanism of these cells in breast cancer (BC) with different ...
Zhiguo Peng +9 more
doaj +3 more sources
Levels of Pathogenic Th17 and Th22 Cells in Patients with Rheumatoid Arthritis [PDF]
Journal of Immunology Research, 2022 Rheumatoid arthritis (RA) is a chronic autoimmune condition characterized, among others, by tissue damage and activation/differentiation of proinflammatory lymphocytes.
Marlen Vitales-Noyola +7 more
doaj +4 more sources
Th22 Cells/IL-22 Serves as a Protumor Regulator to Drive Poor Prognosis through the JAK-STAT3/MAPK/AKT Signaling Pathway in Non-Small-Cell Lung Cancer [PDF]
Journal of Immunology Research, 2022 The interaction of immune cells and cytokines in the tumor microenvironment affects the development and prognosis of tumors with an unclear potential regulatory mechanism.
Yinan Yao +7 more
doaj +2 more sources
Decreased frequency of Th22 cells and IL-22 cytokine in kidney transplant patients with active cytomegalovirus infection [PDF]
BMC Immunology, 2023 Background The immunity of CD4+ T cell subsets against human cytomegalovirus (HCMV) is considerable due to their essential role in controlling the infection in transplant individuals.
Yashgin Hassanzadeh +3 more
doaj +2 more sources
Th22 Cells Promote Osteoclast Differentiation via Production of IL-22 in Rheumatoid Arthritis [PDF]
Frontiers in Immunology, 2018 T helper (Th) cells can differentiate into functionally distinct subsets and play a pivotal role in inflammatory and autoimmune diseases such as rheumatoid arthritis (RA).
Yusuke Miyazaki +11 more
doaj +2 more sources