Th22 cells promote the transition from homeostatic to reactive microglia in diabetic encephalopathy. [PDF]
Acta DiabetolDiabetic encephalopathy (DE) is one of the most serious complications of diabetes mellitus (DM), and its pathogenesis has not yet been clarified.
Yu SX +11 more
europepmc +2 more sources
IL-22 produced by Th22 cells aggravates atherosclerosis development in ApoE-/- mice by enhancing DC-induced Th17 cell proliferation. [PDF]
J Cell Mol Med, 2020 Th22 cells are a novel subset of CD4+ T cells that primarily mediate biological effects through IL‐22, with both Th22 cells and IL‐22 being closely associated with multiple autoimmune and chronic inflammatory diseases.
Shi L +14 more
europepmc +2 more sources
Circulating Th17, Th22, and Th1 Cells Are Increased in Psoriasis [PDF]
Journal of Investigative Dermatology, 2010 Th17, Th22, and Th1 cells are detected in psoriatic skin lesions and implicated in psoriasis pathogenesis, but inflammatory T cell numbers in blood, as well as the relative importance of each cell type, is unclear. Using 7-color flow cytometry, circulating Th17, Th22, and Th1 cells were quantified in 21 untreated psoriatics and 17 healthy individuals ...
Kagami, Shinji +4 more
openaire +4 more sources
The expression of Th9 and Th22 cells in rats with cerebral palsy after hUC-MSC transplantation. [PDF]
J Chin Med Assoc, 2020 Background: This study aimed to investigate the expression of Th9 and Th22 cells in rats with cerebral palsy (CP) after human umbilical cord-derived mesenchymal stem cell (hUC-MSC) transplantation.
Niu X, Xu X, Luo Z, Wu, Tang J.
europepmc +2 more sources
Th22 Cells Form a Distinct Th Lineage from Th17 Cells In Vitro with Unique Transcriptional Properties and Tbet-Dependent Th1 Plasticity. [PDF]
J Immunol, 2017 Th22 cells are a major source of IL-22 and have been found at sites of infection and in a range of inflammatory diseases. However, their molecular characteristics and functional roles remain largely unknown because of our inability to generate and ...
Plank MW +8 more
europepmc +2 more sources
Th22 cells are associated with hepatocellular carcinoma development and progression. [PDF]
Chin J Cancer Res, 2014 IL-22-producing CD4(+) T helper cells (Th22 cells) have been identified as major inducers of tissue inflammation and immune responses. Currently, no previous study explored the role of Th22 cells in the pathogenesis of hepatocellular carcinoma (HCC).
Qin S +5 more
europepmc +5 more sources
Circulating Th17 and Th22 Cells Are Associated With CMR Imaging Biosignatures of Diffuse Myocardial Interstitial Remodeling in Chronic Coronary Artery Disease. [PDF]
Circ Res, 2020 Correspondence to: Jedrzej Hoffmann, Department of Cardiology, Center of Internal Medicine, University Hospital Frankfurt, Germany. Email jedrzej.hoffmann@kgu.de The data that support the findings of this study are available from the corresponding author
Hoffmann J +8 more
europepmc +2 more sources
Increased circulating Th22 cells in patients with acute gouty arthritis: A CONSORT-compliant article. [PDF]
Medicine (Baltimore), 2017 Background: T-helper 22 (Th22) cells are involved in host immunity against pathogen invasion and have been implicated in the pathogenesis of inflammatory diseases. However, the roles of Th22 cells in acute gouty arthritis remain unclear.
Luo G, Yi T, Zhang G, Guo X, Jiang X.
europepmc +2 more sources
The NOTCH-HES-1 axis is involved in promoting Th22 cell differentiation [PDF]
Cellular & Molecular Biology Letters, 2021 Background NOTCH signaling has been shown to play a role in the production of interleukin-22 (IL-22) by CD4+ T cells. Multiple T-helper (Th) cell populations secrete IL-22.
Chong Zeng +7 more
doaj +3 more sources
Increased frequencies of Th22 cells as well as Th17 cells in the peripheral blood of patients with ankylosing spondylitis and rheumatoid arthritis. [PDF]
PLoS ONE, 2012 BackgroundT-helper (Th) 22 is involved in the pathogenesis of inflammatory diseases. The roles of Th22 cells in the pathophysiological of ankylosing spondylitis (AS) and rheumatoid arthritis (RA) remain unsettled.
Lei Zhang +11 more
doaj +2 more sources