Results 31 to 40 of about 4,736,482 (176)
B cells control lupus autoimmunity by inhibiting Th17 and promoting Th22 cells. [PDF]
Cell Death Dis, 2020 AbstractB cells exert immunosuppressive effects and offer therapeutic potential for systemic lupus erythematosus (SLE), but the mechanism remains unclear. Here we analyzed the B cell regulation of Th17/Th22 cell differentiation in lupus and found that α-IgM- and α-CD40-activated B cells could inhibit Th17 and promote Th22 cell differentiation from ...
Yang J, Yang X, Wang L, Li M.
europepmc +4 more sources
The Role of T Helper 22 Cells in Dermatological Disorders
Frontiers in Immunology, 2022 T helper 22 (Th22) cells are a newly identified subset of CD4+ T cells that secrete the effector cytokine interleukin 22 (IL-22) upon specific antigen stimulation, barely with IFN-γ or IL-17. Increasing studies have demonstrated that Th22 cells and IL-22
Yu Pan +12 more
doaj +1 more source
Elevated Th22 cells and related cytokines in patients with epithelial ovarian cancer. [PDF]
Medicine (Baltimore), 2017 This study is conducted to investigate the involvement of T-helper (Th) cells and regulatory T cells in epithelial ovarian cancer (EOC).The percentages of Th22, Th17, Th1, and regulatory T cells in the peripheral blood of EOC patients, benign ovarian epithelial neoplasm (BOEN) patients, and healthy control (HC) were examined by flow cytometry.
Wang T +8 more
europepmc +3 more sources
Th17 and Th22 cells in psoriatic arthritis and psoriasis. [PDF]
Arthritis Res Ther, 2013 Abstract Introduction The aim of this study was to characterize interleukin 17 (IL-17) and interleukin 22 (IL-22) producing cells in peripheral blood (PB), skin, synovial fluid (SF) and synovial tissue (ST) in patients with psoriasis (Ps) and psoriatic arthritis (PsA).
Benham H +8 more
europepmc +8 more sources
Circulating Th17, Th22, and Th1 Cells Are Increased in Psoriasis [PDF]
Journal of Investigative Dermatology, 2010 Th17, Th22, and Th1 cells are detected in psoriatic skin lesions and implicated in psoriasis pathogenesis, but inflammatory T cell numbers in blood, as well as the relative importance of each cell type, is unclear. Using 7-color flow cytometry, circulating Th17, Th22, and Th1 cells were quantified in 21 untreated psoriatics and 17 healthy individuals ...
Kagami, Shinji +4 more
openaire +2 more sources
Importance of Th22 Cell Disequilibrium in Immune Thrombocytopenic Purpura [PDF]
Medical Science Monitor, 2018 BACKGROUND The disequilibrium of T helper (Th) cells play an important role in the occurrence and development of immune thrombocytopenic purpura (ITP). Th22 cells, as a newly discovered subset of T lymphocytes, plays an important role in autoimmune disorders and inflammatory diseases.
Zhan, Feng-xia +4 more
openaire +2 more sources
The clinical significance of intrahepatic Th22 cells in liver cirrhosis [PDF]
Advances in Clinical and Experimental Medicine, 2019 Th22 cells are a recently identified CD4+ T helper subset and have been implicated in the pathogenesis of certain diseases in humans, but the role of Th22 cells in liver cirrhosis (LC) remains unclear.The aim of the study was to investigate the expression and clinical significance of intrahepatic Th22 cells in LC tissues.Samples of liver tissue of 20 ...
Shanyu, Qin +5 more
openaire +2 more sources
Pediatrics and Neonatology, 2018 A new population of T cells known as Th22 was described for the first time in 2009. These cells are usually identified by the production of IL-22. However, this cytokine is also secreted by other cells such as Th1, Th2, Th17, natural killers, and innate ...
Laura Tamasauskiene +1 more
doaj +1 more source
Th22 cells are expanded in multiple sclerosis and are resistant to IFN-β [PDF]
Journal of Leukocyte Biology, 2014 AbstractTh1 and Th17 cells have been considered as effectors in mouse EAE and in the human counterpart, MS. Recently, IL-22, a Th17-related, proinflammatory cytokine, has been associated with a new Th cell subset, defined as Th22, involved in chronic inflammatory conditions, such as psoriasis; the role of IL-22 in MS has not yet been elucidated.
ROLLA, SIMONA +9 more
openaire +4 more sources
Increased circulating Th22 cells in patients with acute gouty arthritis: A CONSORT-compliant article. [PDF]
Medicine (Baltimore), 2017 T-helper 22 (Th22) cells are involved in host immunity against pathogen invasion and have been implicated in the pathogenesis of inflammatory diseases. However, the roles of Th22 cells in acute gouty arthritis remain unclear.A case-control study was employed to illustrate the clinical significance of Th22 cells in acute gouty arthritis.
Luo G, Yi T, Zhang G, Guo X, Jiang X.
europepmc +3 more sources