Results 1 to 10 of about 511,615 (263)
Human CD4+ Memory T Cells Can Become CD4+IL-9+ T Cells [PDF]
PLoS ONE, 2010 IL-9 is a growth factor for T- and mast-cells that is secreted by human Th2 cells. We recently reported that IL-4+TGF-beta directs mouse CD4(+)CD25(-)CD62L(+) T cells to commit to inflammatory IL-9 producing CD4(+) T cells.Here we show that human inducible regulatory T cells (iTregs) also express IL-9.
Putheti, P +4 more
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CD4+ T Cells at the Center of Inflammaging [PDF]
Cell Metabolism, 2020 Bharath et al., 2020 report that CD4+ T lymphocytes from aged individuals exhibit defective mitochondrial autophagy, resulting in altered redox metabolism and upregulation of TH17 cytokines, which in turn may contribute to aging-associated chronic inflammation or "inflammaging." Of note, the antiaging drug metformin reverses this autophagy defect and ...
Kroemer, Guido, Zitvogel, Laurence
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The Era of Cytotoxic CD4 T Cells
Frontiers in Immunology, 2022 In 1986, Mosmann and Coffman identified 2 functionally distinct subsets of activated CD4 T cells, Th1 and Th2 cells, being key in distinct T cell mediated responses. Over the past three decades, our understanding of CD4 T cell differentiation has expanded and the initial paradigm of a dichotomic CD4 T cell family has been revisited to accommodate a ...
Mara Cenerenti +7 more
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CD4 T cell cooperation is required for the in vivo activation of CD4 T cells [PDF]
International Immunology, 2009 We address here the role of CD4 T cell cooperation in the activation of CD4 T cells. Administration of aggregated hen egg lysozyme (HEL) without microbial adjuvant to BALB/c mice normally generates cytokine-producing CD4 T cells specific for the HEL major peptide, HEL(105-120), as well as CD4 T cells specific for HEL non-major peptides.
Nathan C, Peters +3 more
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STAT5 and CD4+ T Cell Immunity [PDF]
F1000Research, 2017 STAT5 plays a critical role in the development and function of many cell types. Here, we review the role of STAT5 in the development of T lymphocytes in the thymus and its subsequent role in the differentiation of distinct CD4+helper and regulatory T-cell subsets.
Owen, David L., Farrar, Michael A.
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Current Opinion in Immunology, 2001 There is now compelling evidence that CD4(+) T cells that specialize in the suppression of immune responses play a key role in the control of immune pathology. Recently, there have been a number of reports that have provided information on the generation of CD4(+) regulatory T cells in the thymus and in the periphery.
Read, S, Powrie, F
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The Journal of Experimental Medicine, 2005 CD4+ T cells continuously monitor antigen levels in their environment and adjust their expansion accordingly, as shown on [page 1555][1]. Obst and colleagues demonstrate that when antigen runs out, CD4+ T cell proliferation stops dead in its tracks.
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CD4+T Cells: Differentiation and Functions [PDF]
Clinical and Developmental Immunology, 2012 CD4+T cells are crucial in achieving a regulated effective immune response to pathogens. Naive CD4+T cells are activated after interaction with antigen-MHC complex and differentiate into specific subtypes depending mainly on the cytokine milieu of the microenvironment. Besides the classical T-helper 1 and T-helper 2, other subsets have been identified,
Rishi Vishal Luckheeram +3 more
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A population of CD62Llow NK1.1− CD4+ T cells that resembles NK1.1+ CD4+ T cells [PDF]
European Journal of Immunology, 1998 In MHC class II-/- C57BL/6 (II-/-) mouse spleen, a small population of CD4+ T cells is present of which NK1.1+ CD4+ (NK) T cells comprise 40 to 45%. We report here that many of the NK1.1- CD4+ T cells derived from II-/- mice are also NK T cells. They produce large amounts of IL-4 in response to anti-CD3 ligation and do so without any requirement for ...
H, Chen, W E, Paul
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CD4+ T cells in atherosclerosis
Biomedicine & Pharmacotherapy, 2003 Atherosclerosis is an inflammatory disease. T lymphocytes, occurring concomitantly with macrophages, are found in atherosclerotic lesions with substantial numbers in all stages. Most of the T cells in the lesions are CD4(+) T cells. The finding of activated T cells and macrophages in lesions and cloning of T cells specific for modified low-density ...
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