Results 21 to 30 of about 511,615 (263)
Journal for ImmunoTherapy of Cancer, 2019 Background Transient CD4+ T cell depletion led to the proliferation of tumor-specific CD8+ T cells in the draining lymph node and increased infiltration of PD-1+CD8+ T cells into the tumor, which resulted in strong anti-tumor effects in tumor-bearing ...
Kohei Shitara +20 more
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Association of progressive CD4(+) T cell decline in SIV infection with the induction of autoreactive antibodies. [PDF]
PLoS Pathogens, 2009 The progressive decline of CD4(+) T cells is a hallmark of disease progression in human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infection.
Takeo Kuwata +9 more
doaj +1 more source
Generation and Immune Regulation of CD4+CD25−Foxp3+ T Cells in Chronic Obstructive Pulmonary Disease
Frontiers in Immunology, 2019 The imbalance of CD4+Foxp3+ T cell subsets is reportedly involved in abnormal inflammatory immune responses in patients with chronic obstructive pulmonary disease (COPD).
Jiang-Hua Wu +8 more
doaj +1 more source
The role of CD4+ T cells in tumor and chronic viral immune responses
MedComm, 2023 Immunotherapies are mainly aimed to promote a CD8+ T cell response rather than a CD4+ T cell response as cytotoxic T lymphocytes (CTLs) can directly kill target cells.
Luoyingzi Xie +6 more
doaj +1 more source
T Regulatory Cells Frequency During Maintenance Phase Chemotherapy for Pediatric Acute Lymphoblastic Leukemia [PDF]
Iranian Journal of Immunology, 2020 Background: Drugs used in cancer treatment specifically kill T regulatory cells. Objective: To determine different phenotypes of T regulatory cells during the maintenance phase chemotherapy for pediatric acute lymphoblastic leukemia (ALL).
Marina Nayeli Medina-Rosales +2 more
doaj +1 more source
Protective effector memory CD4 T cells depend on ICOS for survival. [PDF]
PLoS ONE, 2011 Memory CD4 T cells play a vital role in protection against re-infection by pathogens as diverse as helminthes or influenza viruses. Inducible costimulator (ICOS) is highly expressed on memory CD4 T cells and has been shown to augment proliferation and ...
Tamson V Moore +8 more
doaj +1 more source
Journal of Neuroinflammation, 2020 Background After peripheral nerve transection, facial motoneuron (FMN) survival depends on an intact CD4+ T cell population and a central source of interleukin-10 (IL-10). However, it has not been determined previously whether CD4+ T cells participate in
Elizabeth M. Runge +5 more
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Frontiers in Immunology, 2016 During an immune reaction, some antigen-experienced CD4 T cells relocate from secondary lymphoid organs (SLOs) to the bone marrow (BM) in a CD49b-dependent manner and reside and rest there as professional memory CD4 T cells.
Shintaro eHojyo +11 more
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Distinct susceptibility of HIV vaccine vector-induced CD4 T cells to HIV infection. [PDF]
PLoS Pathogens, 2018 The concerns raised from adenovirus 5 (Ad5)-based HIV vaccine clinical trials, where excess HIV infections were observed in some vaccine recipients, have highlighted the importance of understanding host responses to vaccine vectors and the HIV ...
Sarah Auclair +16 more
doaj +1 more source
The type of responder T-cell has a significant impact in a human in vitro suppression assay. [PDF]
PLoS ONE, 2010 In type 1 diabetes (T1D), a prototypic autoimmune disease, effector T cells destroy beta cells. Normally, CD4(+)CD25(+high), or natural regulatory T cells (Tregs), counter this assault.
Srikanta Jana +7 more
doaj +1 more source