Dysfunction and Metabolic Reprogramming of Gut Regulatory T Cells in HIV-Infected Immunological Non-Responders [PDF]
CellsDisruption of the gut microenvironment is a hallmark of HIV infection, where regulatory T cells (Tregs) play a critical role in maintaining gut homeostasis.
Mengmeng Qu, Chao Zhang, Xing Fan
exaly +8 more sources
Severe intestinal barrier damage in HIV-infected immunological non-responders [PDF]
Heliyon, 2023 The intestinal epithelial barrier plays an important role during human immunodeficiency virus (HIV) disease progression. However, the extent to which the intestinal epithelial barrier is damaged in immunological non-responders (INRs) and immunological ...
Mengmeng Qu, Yaokai Chen
exaly +6 more sources
HIV immunological non-responders are characterized by extensive immunosenescence and impaired lymphocyte cytokine production capacity [PDF]
Frontiers in ImmunologyIntroductionImmunological non-responders (INR) are people living with HIV (PLHIV) who fail to fully restore CD4+ T-cell counts despite complete viral suppression with antiretroviral therapy (ART).
Adriana Navas +2 more
exaly +10 more sources
Characteristics and influencing factors of immunological non-responders in HIV-1-infected patients receiving antiretroviral therapy: a cross-sectional study in Guangxi [PDF]
Scientific ReportsThe prevalence of AIDS and mortality rates among HIV-infected individuals in Guangxi remain relatively high, potentially due to impaired CD4 + cell recovery. This study aims to identify factors hindering CD4 + cell recovery in people living with HIV.
Qiuying Zhu +2 more
exaly +4 more sources
Immune cell subset profiling and metabolic dysregulation define the divergent immune microenvironments in HIV immunological non‐responders [PDF]
Clinical and Translational MedicineBackground A subset of people living with HIV (PLWH) exhibit poor immune recovery despite effective antiretroviral therapy (ART), remaining at risk of disease progression.
Qingfei Chu
exaly +5 more sources
Elevated Levels of Pro-Inflammatory Interleukin-6 in HIV Immunological Non-Responders Among the Indonesian Population [PDF]
DiagnosticsApproximately 10–35% of people living with HIV (PLHIV) on antiretroviral therapy (ART) fail to restore CD4+ T cell counts, a state known as immunological non-responder (INR) characterized by persistent immune activation and elevated cytokine levels ...
Anton Sumarpo +2 more
exaly +6 more sources
Editorial: Immunological non-responders in HIV infection [PDF]
Frontiers in ImmunologyKonstantin Shmagel +2 more
exaly +6 more sources
Abnormal characteristics of intestinal microenvironment in HIV immunological non-responders [PDF]
Frontiers in ImmunologyAcquired immunodeficiency syndrome (AIDS) is one of the most dangerous diseases threatening global public health. Antiretroviral therapy (ART) is currently the primary treatment for people living with HIV (PLWH).
Huanxia Liu, Huanxia Liu, Yanguang Yang
doaj +3 more sources
Genomic landscape of HIV-1 proviruses in ART-treated immunological non-responders [PDF]
Frontiers in ImmunologyBackgroundImmunological non-responders (INRs) and immunological responders (IRs) exhibit distinct patterns of immune reconstitution despite suppressive antiretroviral therapy (ART); however, the genetic characteristics of the HIV-1 reservoir in these ...
Shengquan Tang +13 more
doaj +3 more sources
An atlas of immune cell transcriptomes in human immunodeficiency virus-infected immunological non-responders identified marker genes that control viral replication [PDF]
Chinese Medical Journal, 2023 . Background:. Previous studies have examined the bulk transcriptome of peripheral blood immune cells in acquired immunodeficiency syndrome patients experiencing immunological non-responsiveness.
Yahong Chen +11 more
doaj +2 more sources