Results 11 to 20 of about 10,572,916 (223)

Lipoprotein Profile in Immunological Non-Responders PLHIV After Antiretroviral Therapy Initiation [PDF]

International Journal of Molecular Sciences, 2022
Nuclear magnetic resonance (NMR)-based advanced lipoprotein tests have demonstrated that LDL and HDL particle numbers (LDL-P and HDL-P) are more powerful cardiovascular (CV) risk biomarkers than conventional cholesterol markers.
Anna Rull, Jesús Miguel López Dupla, Pere Domingo   +2 more
exaly   +10 more sources

Dysfunction and Metabolic Reprogramming of Gut Regulatory T Cells in HIV-Infected Immunological Non-Responders [PDF]

Cells
Disruption of the gut microenvironment is a hallmark of HIV infection, where regulatory T cells (Tregs) play a critical role in maintaining gut homeostasis.
Meng-Meng Qu, Chao Zhang, Xing Fan
exaly   +6 more sources

Severe Intestinal Barrier Damage in HIV-Infected Immunological Non-Responders [PDF]

Heliyon, 2023
The intestinal epithelial barrier plays an important role during human immunodeficiency virus (HIV) disease progression. However, the extent to which the intestinal epithelial barrier is damaged in immunological non-responders (INRs) and immunological responders (IRs) is largely unknown.
Meng-Meng Qu, Yaokai Chen, Ze-Rui Wang
exaly   +5 more sources

Identification of Potential Diagnostic Genes of HIV-Infected Immunological Non-Responders on Bioinformatics Analysis [PDF]

Journal of Inflammation Research, 2023
HIV-infected immunological non-responders (INRs) failed to achieve the normalization of CD4+ T cell counts despite their undetectable viral load. INRs have an increased risk of clinical progressions of Acquired Immunodeficiency Syndrome (AIDS) and non-AIDS events, accompanied by higher mortality rates than immunological responders (IRs).
Gaoyan Tang, Yanhong Ding
exaly   +6 more sources

Editorial: Immunological Non-Responders in HIV Infection [PDF]

Frontiers in Immunology
Konstantin Shmagel, Scott F Sieg, Evgeniya Saidakova   +2 more
exaly   +5 more sources

Characteristics and Influencing Factors of Immunological Non-Responders in HIV-1-Infected Patients Receiving Antiretroviral Therapy: A Cross-Sectional Study in Guangxi [PDF]

Scientific Reports
The prevalence of AIDS and mortality rates among HIV-infected individuals in Guangxi remain relatively high, potentially due to impaired CD4 + cell recovery. This study aims to identify factors hindering CD4 + cell recovery in people living with HIV.
Qiuying Zhu, Kailing Tang, Xianwu Pang
exaly   +3 more sources

Elucidating the Gene Signatures and Immune Cell Types in HIV-Infected Immunological Non-Responders by Bioinformatics Analyses [PDF]

International Journal of General Medicine, 2022
Numerous studies have reported on the pathogenesis of poor immune reconstitution (PIR) after antiretroviral treatment in human immunodeficiency virus (HIV) patients. However, fewer studies focused on both immune-related genes (IRGs) and immune cells, and the correlation between IRGs and immune cells was evaluated via bioinformatics analyses.Gene ...
Fujie Zhang, Lina Fan, Qing Xiao
exaly   +6 more sources

Unveiling neuroimmunology profile of immunological non-responders in HIV: a multimodal MRI approach. [PDF]

Front Immunol
BackgroundPeople living with HIV (PLWH), especially immunological non-responders (INRs), may experience adverse neurologic events. However, the extent of neurological impairment in INRs remains uncertain. This study evaluates brain structure and function,
Zhang Y, Ji J, Zheng L, Cai M, Sun G, Ma Y, Zhang X, Chen X, Zhang Y, Lin X, Li Z, Zhang T.   +11 more
europepmc   +5 more sources

HIV Immunological Non-Responders Are Characterized by Extensive Immunosenescence and Impaired Lymphocyte Cytokine Production Capacity [PDF]

Frontiers in Immunology
IntroductionImmunological non-responders (INR) are people living with HIV (PLHIV) who fail to fully restore CD4+ T-cell counts despite complete viral suppression with antiretroviral therapy (ART). INR are at higher risk for non-HIV related morbidity and mortality.
Kees Brinkman, Jan van Lunzen, Willem L Blok   +2 more
exaly   +7 more sources

Enhanced Gut-Homing Dynamics and Pronounced Exhaustion of Mucosal and Blood CD4⁺ T Cells in HIV-Infected Immunological Non-Responders. [PDF]

Front Immunol, 2021
Immunological non-responders (INR), a subgroup of people living with HIV (PLHIV) who fail to restore CD4 + T cell numbers upon effective antiretroviral treatment, have impaired gut mucosal barrier function and an inferior clinical prognosis compared with
Lorvik KB, Meyer-Myklestad MH, Kushekar K, Handeland C, Medhus AW, Lund-Iversen M, Stiksrud B, Kvale D, Dyrhol-Riise AM, Taskén K, Reikvam DH.   +10 more
europepmc   +8 more sources