Results 11 to 20 of about 10,181,415 (248)

Unveiling neuroimmunology profile of immunological non-responders in HIV: a multimodal MRI approach [PDF]

Frontiers in Immunology
BackgroundPeople living with HIV (PLWH), especially immunological non-responders (INRs), may experience adverse neurologic events. However, the extent of neurological impairment in INRs remains uncertain. This study evaluates brain structure and function,
Yang Zhang, Yang Zhang, Yang Zhang, Jiahao Ji, Luyao Zheng, Miaotian Cai, Guangqiang Sun, Guangqiang Sun, Yundong Ma, Yundong Ma, Xin Zhang, Xue Chen, Yulin Zhang, Xiao Lin, Xiao Lin, Zhen Li, Zhen Li, Tong Zhang, Tong Zhang, Tong Zhang   +19 more
doaj   +6 more sources

Enhanced Gut-Homing Dynamics and Pronounced Exhaustion of Mucosal and Blood CD4+ T Cells in HIV-Infected Immunological Non-Responders [PDF]

Frontiers in Immunology, 2021
Immunological non-responders (INR), a subgroup of people living with HIV (PLHIV) who fail to restore CD4+ T cell numbers upon effective antiretroviral treatment, have impaired gut mucosal barrier function and an inferior clinical prognosis compared with ...
Kristina Berg Lorvik, Kristina Berg Lorvik, Kristina Berg Lorvik, Malin Holm Meyer-Myklestad, Malin Holm Meyer-Myklestad, Kushi Kushekar, Kushi Kushekar, Charlotte Handeland, Asle Wilhelm Medhus, Marius Lund-Iversen, Birgitte Stiksrud, Dag Kvale, Dag Kvale, Anne Margarita Dyrhol-Riise, Anne Margarita Dyrhol-Riise, Kjetil Taskén, Kjetil Taskén, Kjetil Taskén, Dag Henrik Reikvam, Dag Henrik Reikvam   +19 more
doaj   +8 more sources

Lipoprotein Profile in Immunological Non-Responders PLHIV after Antiretroviral Therapy Initiation [PDF]

International Journal of Molecular Sciences, 2022
Nuclear magnetic resonance (NMR)-based advanced lipoprotein tests have demonstrated that LDL and HDL particle numbers (LDL-P and HDL-P) are more powerful cardiovascular (CV) risk biomarkers than conventional cholesterol markers.
Anna Rull, Jesus Miguel López Dupla, Père Domingo   +2 more
exaly   +11 more sources

Enhanced immune reconstitution with albuvirtide in HIV-infected immunological non-responders [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundIncomplete immune recovery in people living with HIV/AIDS (PLWHA) remains an important clinical challenge with the lack of an effective strategy currently available to restore their T-cell immune response.
Lina Fan, Yue Hu, Yue Hu, Rui Li, Rui Li, Jiaqi Ding, Jiaqi Ding, Yuantao Liu, Shuchang Yu, Min Hu, Rui Su, Yangyang Li, AiPing Yu, Dong Xie, Qingxia Zhao, Ping Ma, Ping Ma   +16 more
doaj   +4 more sources

Elucidating the Gene Signatures and Immune Cell Types in HIV-Infected Immunological Non-Responders by Bioinformatics Analyses [PDF]

International Journal of General Medicine, 2022
Qing Xiao,1,2 Junyan Han,3– 6 Fengting Yu,1– 3 Liting Yan,1,2 Qun Li,1,2 Xiaojie Lao,1,2 Hongxin Zhao,1,2 Fujie Zhang1,2 1Department of Infectious Diseases, Capital Medical University Affiliated Beijing Ditan Hospital, Beijing, People’s Republic of China;
Xiao Q, Han J, Yu F, Yan L, Li Q, Lao X, Zhao H, Zhang F   +7 more
doaj   +4 more sources

Incomplete immune reconstitution in HIV/AIDS patients on antiretroviral therapy: Challenges of immunological non-responders [PDF]

Journal of Leukocyte Biology, 2020
Abstract The morbidity and mortality of HIV type-1 (HIV-1)-related diseases were dramatically diminished by the grounds of the introduction of potent antiretroviral therapy, which induces persistent suppression of HIV-1 replication and gradual recovery of CD4+ T-cell counts.
Bin Su, Tong Zhang, Hao Wu
exaly   +5 more sources

Impact of extended-release niacin on immune activation in HIV-infected immunological non-responders on effective antiretroviral therapy

HIV Research and Clinical Practice, 2020
Background Background: Tryptophan (Trp) catabolism into immunosuppressive kynurenine (Kyn) is involved in immune dysregulation during HIV infection. Niacin (vitamin B3) could control the excess of tryptophan depletion and represents a potential strategy ...
Mohammad-Ali Jenabian, Kim Engler, Jean-Pierre Routy   +2 more
exaly   +5 more sources

Identification of Potential Diagnostic Genes of HIV-Infected Immunological Non-Responders on Bioinformatics Analysis. [PDF]

J Inflamm Res, 2023
Yanhong Ding,1,* Cheng Pu,2,* Xiao Zhang,3 Gaoyan Tang,1 Fengjuan Zhang,3 Guohua Yu1 1Department of Medical Oncology, the First Affiliated Hospital of Weifang Medical University, Weifang, 261032, People’s Republic of China; 2Key Laboratory of ...
Ding Y, Pu C, Zhang X, Tang G, Zhang F, Yu G.   +5 more
europepmc   +6 more sources

Single-cell multi-omics profiling uncovers the immune heterogeneity in HIV-infected immunological non-responders [PDF]

EBioMedicine
Immunological non-responders (INRs) are people living with HIV-1 who fail to achieve full immune reconstitution despite long-term effective antiretroviral therapy (ART). This incomplete recovery of CD4+ T cells increase the risk of opportunistic infections and non-AIDS-related morbidity and mortality.
Tai-Sheng Li, Xiaosheng Liu, Lianfeng Lu   +2 more
exaly   +4 more sources

HIV-Sheltering Platelets From Immunological Non-Responders Induce a Dysfunctional Glycolytic CD4⁺ T-Cell Profile. [PDF]

Front Immunol, 2021
International audienceImmunological non-responders (InRs) are HIV-infected individuals in whom the administration of combination antiretroviral therapy (cART), although successful in suppressing viral replication, cannot properly reconstitute patient ...
Zhu A, Real F, Zhu J, Greffe S, de Truchis P, Rouveix E, Bomsel M, Capron C.   +7 more
europepmc   +9 more sources