Results 21 to 30 of about 10,181,415 (248)

Association between CD4+ T cell counts and gut microbiota and serum cytokines levels in HIV-infected immunological non-responders [PDF]

BMC Infectious Diseases, 2021
Background CD4+ T cell counts in certain human immunodeficiency virus (HIV)-infected patients called immunological non-responders (INRs) could not return to a normal level even with sustained antiretroviral therapy (ART) because of persistent immune ...
Danfeng Lu, Jian-Bo Zhang, Yue-Xin Wang, Shi-Tao Geng, Zunyue Zhang, Yu Xu, Shao-You Li, Kun-Hua Wang, Yi-Qun Kuang   +8 more
doaj   +2 more sources

Signature genes associated with immunological non-responsiveness to anti-retroviral therapy in HIV-1 subtype-c infection.

PLoS ONE, 2020
ObjectiveHIV-infected individuals undergoing therapy may show an immunological-discordant response to therapy, with poor CD4+ T cells recovery, despite viral suppression below the detection limit.
Sukhvinder Singh, Jaideep S Toor, Aman Sharma, Sunil K Arora   +3 more
doaj   +2 more sources

Incomplete functional T-cell reconstitution in immunological non-responders at one year after initiation of antiretroviral therapy possibly predisposes them to infectious diseases

International Journal of Infectious Diseases, 2019
Background: Immunological non-responders (INR) represent a unique category of HIV-infected patients on antiretroviral therapy. These patients have suppressed viremia but a suboptimal increase in CD4 cell count, which might have opposing effects on ...
Raman Gangakhedkar, Ashwini Shete, Girish Rahane   +2 more
exaly   +3 more sources

Markers of CD4⁺ AND CD8⁺ T-cell exhaustion in hiv/hcv coinfected immunological non-responders to antiretroviral therapy

Инфекция и иммунитет
Coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) is a risk factor for immunological non-response to antiretroviral therapy.
Evgeniya V. Saidakova, L. B. Korolevskaya, V. V. Vlasova, N. G. Shmagel, K. V. Shmagel   +4 more
doaj   +2 more sources

Factors associated with immunological non-response after ART initiation: a retrospective observational cohort study

BMC Infectious Diseases
Background Among people living with HIV (PLHIV) on antiretroviral therapy (ART), the mortality of immunological non-responders (INRs) is higher than that of immunological responders (IRs).
Heping Zhao, Anping Feng, Dan Luo, Tanwei Yuan, Yi-Fan Lin, Xuemei Ling, Huolin Zhong, Junbin Li, Linghua Li, Huachun Zou   +9 more
doaj   +2 more sources

Comparative Transcriptional Analysis Identified Characteristic Genes and Patterns in HIV-Infected Immunological Non-Responders. [PDF]

Front Immunol, 2022
PurposeThe incomplete immune reconstitution is a complex phenomenon among human immunodeficiency virus (HIV)-infected patients despite the fact that they have achieved persistent viral suppression under the combined antiretroviral therapy. This study aims to screen and verify the immunological characteristics and underlying mechanisms of immunological ...
Liu X, Lin L, Lu L, Li X, Han Y, Qiu Z, Li X, Li Y, Song X, Cao W, Li T.   +10 more
europepmc   +5 more sources

Anti-SARS-COV-2 specific immunity in HIV immunological non-responders after mRNA-based COVID-19 vaccination [PDF]

Frontiers in Immunology, 2022
Natalia Garcia-Giralt, Güerri-Fernandez R, Marta Sisteré   +2 more
exaly   +2 more sources

Gut and skin microbial dysbiosis correlate with systemic inflammation and pruritus in immunological non-responders. [PDF]

Front Microbiol
Introduction Among people living with human immunodeficiency virus (PLWH), those who exhibit immunological non-responders (INR) are highly susceptible to developing pruritus. The aim of this study was to examine the relationships among pruritus, alteration of the gut and skin microbiomes, and systemic ...
Li J, Xu L, Ding X, Qiu N, Yue J.
europepmc   +2 more sources

Metformin may be a viable adjunctive therapeutic option to potentially enhance immune reconstitution in HIV-positive immunological non-responders. [PDF]

Chin Med J (Engl), 2023
Abstract Incomplete immune reconstitution remains a global challenge for human immunodeficiency virus (HIV) treatment in the present era of potent antiretroviral therapy (ART), especially for those individuals referred to as immunological non-responders (INRs), who exhibit dramatically low
Zaongo SD, Chen Y.
europepmc   +4 more sources

Higher proportions of circulating CXCR3+ CCR6− Tfh cells as a hallmark of impaired CD4+ T-cell recovery in HIV-1-infected immunological non-responders [PDF]

MBio
Udaykumar Ranga, Manjunatha Venkataswamy   +1 more
exaly   +2 more sources