Results 21 to 30 of about 10,572,916 (223)

Single-Cell Multi-Omics Profiling Uncovers the Immune Heterogeneity in HIV-Infected Immunological Non-Responders [PDF]

EBioMedicine
Immunological non-responders (INRs) are people living with HIV-1 who fail to achieve full immune reconstitution despite long-term effective antiretroviral therapy (ART). This incomplete recovery of CD4+ T cells increase the risk of opportunistic infections and non-AIDS-related morbidity and mortality.
Taisheng Li, Xiaosheng Liu, Lianfeng Lu
exaly   +4 more sources

Elevated Levels of Pro-Inflammatory Interleukin-6 in HIV Immunological Non-Responders Among the Indonesian Population [PDF]

Diagnostics
Approximately 10–35% of people living with HIV (PLHIV) on antiretroviral therapy (ART) fail to restore CD4+ T cell counts, a state known as immunological non-responder (INR) characterized by persistent immune activation and elevated cytokine levels. Objective: This study aimed to identify cytokines that can serve as biomarkers for immune activation and
Anton Sumarpo, Dewi Kartika Turbawaty, Fitri Fadhilah   +2 more
exaly   +5 more sources

HIV-Sheltering Platelets From Immunological Non-Responders Induce a Dysfunctional Glycolytic CD4⁺ T-Cell Profile. [PDF]

Front Immunol, 2021
International audienceImmunological non-responders (InRs) are HIV-infected individuals in whom the administration of combination antiretroviral therapy (cART), although successful in suppressing viral replication, cannot properly reconstitute patient ...
Zhu A, Real F, Zhu J, Greffe S, de Truchis P, Rouveix E, Bomsel M, Capron C.   +7 more
europepmc   +9 more sources

Immune Cell Subset Profiling and Metabolic Dysregulation Define the Divergent Immune Microenvironments in HIV Immunological Non-Responders [PDF]

Clinical and Translational Medicine
Abstract Background A subset of people living with HIV (PLWH) exhibit poor immune recovery despite effective antiretroviral therapy (ART), remaining at risk of disease progression. The immunometabolic mechanisms underlying this immunological non‐response remain unclear.
Abdur Rashid, Qingfei Chu, Ningye Fang
exaly   +4 more sources

Activated/Cycling Treg Deficiency and Mitochondrial Alterations in Immunological Non-Responders to Antiretroviral Therapy

Frontiers in Bioscience-Landmark
Background: Regulatory T-cells (Tregs) play a crucial role in maintaining immune homeostasis, but their dynamics are altered in a subset of people living with Human Immunodeficiency Virus (HIV) known as immunological non-responders ...
Larisa Korolevskaya, Konstantin Shmagel, Souheil-Antoine Younes, Violetta Vlasova, Evgeniya Saidakova   +4 more
core   +4 more sources

Abnormal characteristics of intestinal microenvironment in HIV immunological non-responders. [PDF]

Front Immunol
Acquired immunodeficiency syndrome (AIDS) is one of the most dangerous diseases threatening global public health. Antiretroviral therapy (ART) is currently the primary treatment for people living with HIV (PLWH). However, some patients are classified as immunological non-responders (INRs), defined by the failure to achieve adequate
Liu H, Yang Y.
europepmc   +2 more sources

Genomic landscape of HIV-1 proviruses in ART-treated immunological non-responders. [PDF]

Front Immunol
Background Immunological non-responders (INRs) and immunological responders (IRs) exhibit distinct patterns of immune reconstitution despite suppressive antiretroviral therapy (ART); however, the genetic ...
Tang S, Wang Y, Lu Y, Tong Z, Guo J, Cui Y, Harypursat V, Chen Y, Ouyang J, Li H, Wang T, Zhou Q, Chen Y.   +12 more
europepmc   +2 more sources

Comparative Transcriptional Analysis Identified Characteristic Genes and Patterns in HIV-Infected Immunological Non-Responders. [PDF]

Front Immunol, 2022
PurposeThe incomplete immune reconstitution is a complex phenomenon among human immunodeficiency virus (HIV)-infected patients despite the fact that they have achieved persistent viral suppression under the combined antiretroviral therapy. This study aims to screen and verify the immunological characteristics and underlying mechanisms of immunological ...
Liu X, Lin L, Lu L, Li X, Han Y, Qiu Z, Li X, Li Y, Song X, Cao W, Li T.   +10 more
europepmc   +5 more sources

Enhanced immune reconstitution with albuvirtide in HIV-infected immunological non-responders. [PDF]

Front Cell Infect Microbiol
BackgroundIncomplete immune recovery in people living with HIV/AIDS (PLWHA) remains an important clinical challenge with the lack of an effective strategy currently available to restore their T-cell immune response. This study aimed to evaluate the effect of Albuvirtide (ABT) on immune recovery in immunological non-responders (INRs) and attempted to ...
Fan L, Hu Y, Li R, Ding J, Liu Y, Yu S, Hu M, Su R, Li Y, Yu A, Xie D, Zhao Q, Ma P.   +12 more
europepmc   +4 more sources

Anti-SARS-COV-2 Specific Immunity in HIV Immunological Non-Responders After mRNA-Based COVID-19 Vaccination [PDF]

Frontiers in Immunology, 2022
Natalia Garcia-Giralt, Robert Güerri-Fernández, Andreas Meyerhans   +2 more
exaly   +2 more sources