Results 11 to 20 of about 672,678 (303)
Human CD4 memory T cells can become CD4+IL-9+ T cells. [PDF]
PLoS ONE, 2010 IL-9 is a growth factor for T- and mast-cells that is secreted by human Th2 cells. We recently reported that IL-4+TGF-beta directs mouse CD4(+)CD25(-)CD62L(+) T cells to commit to inflammatory IL-9 producing CD4(+) T cells.Here we show that human ...
Prabhakar Putheti +4 more
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CD4+ T Cells at the Center of Inflammaging [PDF]
Cell Metabolism, 2020 Bharath et al., 2020 report that CD4+ T lymphocytes from aged individuals exhibit defective mitochondrial autophagy, resulting in altered redox metabolism and upregulation of TH17 cytokines, which in turn may contribute to aging-associated chronic inflammation or "inflammaging." Of note, the antiaging drug metformin reverses this autophagy defect and ...
Kroemer, Guido, Zitvogel, Laurence
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Frontiers in Immunology, 2022 Cytotoxic CD8+ T cells are the main focus of efforts to understand anti-tumor immunity and immunotherapy. The adoptive transfer of tumor-reactive cytotoxic CD8+ T lymphocytes expanded and differentiated in vitro has long been considered the primary ...
Qiao Liu +17 more
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The Era of Cytotoxic CD4 T Cells
Frontiers in Immunology, 2022 In 1986, Mosmann and Coffman identified 2 functionally distinct subsets of activated CD4 T cells, Th1 and Th2 cells, being key in distinct T cell mediated responses. Over the past three decades, our understanding of CD4 T cell differentiation has expanded and the initial paradigm of a dichotomic CD4 T cell family has been revisited to accommodate a ...
Mara Cenerenti +7 more
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BMC Pulmonary Medicine, 2021 Background Treatment for non-small cell lung cancer (NSCLC) has greatly improved in recent years. However, noninvasive early screening for carcinogenesis and progression unclear.
Yingyi Wang +11 more
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CD4 T cell cooperation is required for the in vivo activation of CD4 T cells [PDF]
International Immunology, 2009 We address here the role of CD4 T cell cooperation in the activation of CD4 T cells. Administration of aggregated hen egg lysozyme (HEL) without microbial adjuvant to BALB/c mice normally generates cytokine-producing CD4 T cells specific for the HEL major peptide, HEL(105-120), as well as CD4 T cells specific for HEL non-major peptides.
Nathan C, Peters +3 more
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Regulation and gene expression profiling of NKG2D positive human cytomegalovirus-primed CD4+ T-cells. [PDF]
PLoS ONE, 2012 NKG2D is a stimulatory receptor expressed by natural killer (NK) cells, CD8(+) T-cells, and γδ T-cells. NKG2D expression is normally absent from CD4(+) T-cells, however recently a subset of NKG2D(+) CD4(+) T-cells has been found, which is specific for ...
Helle Jensen +2 more
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STAT5 and CD4+ T Cell Immunity [PDF]
F1000Research, 2017 STAT5 plays a critical role in the development and function of many cell types. Here, we review the role of STAT5 in the development of T lymphocytes in the thymus and its subsequent role in the differentiation of distinct CD4+helper and regulatory T-cell subsets.
Owen, David L., Farrar, Michael A.
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Failure of CD4 T-cells to respond to liver-derived antigen and to provide help to CD8 T-cells. [PDF]
PLoS ONE, 2011 CD4 T-cell help is required for the induction of efficient CD8 T-cells responses and the generation of memory cells. Lack of CD4 T-cell help may contribute to an exhausted CD8 phenotype and viral persistence.
Katja Derkow +9 more
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Metabolic features of naïve and memory CD4+T cells in quiescence and during proliferation
Acta Biomedica Scientifica, 2022 Background. Memory CD4+ T cells proliferation is the basis for accelerated secondary immune response. The characteristics of memory CD4+ T cells providing their faster division compared to naive CD4+ T lymphocytes are poorly understood.
V. V. Vlasova +4 more
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