Results 11 to 20 of about 514,797 (263)
STAT5 and CD4+ T Cell Immunity [PDF]
F1000Research, 2017 STAT5 plays a critical role in the development and function of many cell types. Here, we review the role of STAT5 in the development of T lymphocytes in the thymus and its subsequent role in the differentiation of distinct CD4+helper and regulatory T-cell subsets.
Owen, David L., Farrar, Michael A.
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CD4(+)CD62L(+) central memory T cells can be converted to Foxp3(+) T cells. [PDF]
PLoS ONE, 2013 The peripheral Foxp3(+) Treg pool consists of naturally arising Treg (nTreg) and adaptive Treg cells (iTreg). It is well known that naive CD4(+) T cells can be readily converted to Foxp3(+) iTreg in vitro, and memory CD4(+) T cells are resistant to ...
Xiaolong Zhang +5 more
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Failure of CD4 T-cells to respond to liver-derived antigen and to provide help to CD8 T-cells. [PDF]
PLoS ONE, 2011 CD4 T-cell help is required for the induction of efficient CD8 T-cells responses and the generation of memory cells. Lack of CD4 T-cell help may contribute to an exhausted CD8 phenotype and viral persistence.
Katja Derkow +9 more
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Cell Reports, 2023 Summary: CD4+ T cells are key components of the immune response during lung infections and can mediate protection against tuberculosis (TB) or influenza. However, CD4+ T cells can also promote lung pathology during these infections, making it unclear how
Igor Santiago-Carvalho +19 more
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CD4+ primary T cells expressing HCV-core protein upregulate Foxp3 and IL-10, suppressing CD4 and CD8 T cells. [PDF]
PLoS ONE, 2014 Adaptive T cell responses are critical for controlling HCV infection. While there is clinical evidence of a relevant role for regulatory T cells in chronic HCV-infected patients, based on their increased number and function; mechanisms underlying such a ...
Cecilia Fernandez-Ponce +3 more
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Current Opinion in Immunology, 2001 There is now compelling evidence that CD4(+) T cells that specialize in the suppression of immune responses play a key role in the control of immune pathology. Recently, there have been a number of reports that have provided information on the generation of CD4(+) regulatory T cells in the thymus and in the periphery.
Read, S, Powrie, F
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Journal for ImmunoTherapy of Cancer, 2019 Background Transient CD4+ T cell depletion led to the proliferation of tumor-specific CD8+ T cells in the draining lymph node and increased infiltration of PD-1+CD8+ T cells into the tumor, which resulted in strong anti-tumor effects in tumor-bearing ...
Kohei Shitara +20 more
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Association of progressive CD4(+) T cell decline in SIV infection with the induction of autoreactive antibodies. [PDF]
PLoS Pathogens, 2009 The progressive decline of CD4(+) T cells is a hallmark of disease progression in human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infection.
Takeo Kuwata +9 more
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The Journal of Experimental Medicine, 2005 CD4+ T cells continuously monitor antigen levels in their environment and adjust their expansion accordingly, as shown on [page 1555][1]. Obst and colleagues demonstrate that when antigen runs out, CD4+ T cell proliferation stops dead in its tracks.
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Generation and Immune Regulation of CD4+CD25−Foxp3+ T Cells in Chronic Obstructive Pulmonary Disease
Frontiers in Immunology, 2019 The imbalance of CD4+Foxp3+ T cell subsets is reportedly involved in abnormal inflammatory immune responses in patients with chronic obstructive pulmonary disease (COPD).
Jiang-Hua Wu +8 more
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