Results 41 to 50 of about 4,736,482 (176)
Clinics, 2021 OBJECTIVES: To investigate the efficacy and potential molecular mechanism of Huangkui capsule in combination with leflunomide (HKL) for the treatment of immunoglobulin A nephropathy (IgAN) METHODS: IgAN rat models were constructed by treating rats with ...
Shuwen Pei, Yan Li
doaj +1 more source
Increased differentiation of Th22 cells in Hashimoto^|^rsquo;s thyroiditis
Endocrine Journal, 2014 As Th22 subsets are identified, their involvement in the pathogenesis of numerous autoimmune diseases has become apparent. In this study, we investigated differentiation of Th22 cells in the autoimmune thyroid diseases including Hashimoto's thyroiditis (HT) and Graves' disease (GD).
Bai, Xue +8 more
openaire +3 more sources
Downregulation of RUNX3 moderates the frequency of Th17 and Th22 cells in patients with psoriasis. [PDF]
Mol Med Rep, 2016 Psoriasis is a common chronic inflammatory and T cell-meditated skin disease. Runt-related transcription factor 3 (RUNX3), one of the runt‑domain family of transcription factors, has been reported to be a susceptibility gene for psoriasis. The present study was designed to delineate the role and underlying mechanism of RUNX3 involved in the ...
Fu D, Song X, Hu H, Sun M, Li Z, Tian Z.
europepmc +4 more sources
Th22 cell accumulation is associated with colorectal cancer development
World Journal of Gastroenterology, 2015 To investigate the expression of Th22 cells and related cytokines in colorectal cancer (CRC) tissues, and the probably mechanism.CRC tumor and paratumor tissues were collected to detect the expression levels of Th22 cells and of related cytokines by immunohistochemistry, flow cytometry and real-time quantitative polymerase chain reaction (RT-qPCR ...
Yong-Hong, Huang +4 more
openaire +2 more sources
Staphylococcal Exotoxins Induce Interleukin 22 in Human Th22 Cells [PDF]
International Archives of Allergy and Immunology, 2014 Background: We have shown previously that T cells from atopic dermatitis (AD) patients produce more IL-22 upon staphylococcal exotoxin stimulation compared to psoriasis patients and healthy controls. The role of staphylococcal exotoxins on polarized memory T helper (Th)22 cells which are enriched in inflamed AD skin remains elusive.
Margarete Niebuhr +4 more
openaire +2 more sources
Expression of Helper and Regulatory T Cells in Atopic Dermatitis: A Meta-Analysis
Frontiers in Pediatrics, 2022 BackgroundAtopic dermatitis (AD) is a common inflammatory skin disease, with the incidence peaks in infancy. A meta-analysis was performed to assess the levels of T helper type 22 (Th22) cells, T helper type 17 (Th17) cells, interleukin (IL)-17, and ...
Dao-jun Zhang +3 more
doaj +1 more source
Virology Journal, 2012 Background Recently, a new subset of T helper (Th) cell that predominantly secret cytokine interleukin-22 (IL-22) is identified, termed Th22 cells. The Th22 subset has been demonstrated to be involved in immunity and tissue inflammation.
Kong Qing +10 more
doaj +1 more source
, 2012 a, Positive correlation was found between Th22 cells and Th17 cells in AS patients. b, Positive correlation was found between Th22 cells and Th17 cells in RA patients.
Lei Qi (173882) +11 more
core +1 more source
Th17 but not Th22 cells display pathological behaviour in arthritis [PDF]
Annals of the Rheumatic Diseases, 2012 Background Th17 cells (IL-17+IL-22+) are critically involved in the induction and progression of arthritis. Recently, Th22 cells were discovered, which were characterised by IL-22 expression in the absence of IL-17. However, it remains unclear whether IL-22 and Th22 cells, directly contribute to synovial inflammation.
Jan Piet van Hamburg +5 more
openaire +1 more source
npj Vaccines, 2023 Therapeutic vaccines have promise as adjunctive treatment for tuberculosis (TB) or as preventives against TB relapse. An important development challenge is the limited understanding of T helper (Th) cell roles during these stages of disease.
Yazmin B. Martinez-Martinez +5 more
doaj +1 more source