Results 51 to 60 of about 8,035 (194)
Atopic dermatitis: immune deviation, barrier dysfunction, IgE autoreactivity and new therapies
Allergology International, 2017 Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder mostly associated with IgE elevation and skin barrier dysfunction due to decreased filaggrin expression.
Masutaka Furue +6 more
doaj +1 more source
Spatial Transcriptomics Identifies Characteristic Immunological Niches in Atopic Dermatitis
Allergy, EarlyView.Spatially organized immune niches containing mature migratory dendritic cells (mmDCs) and CD4+ T cells in atopic dermatitis lesions support localized T cell activation and may contribute to disease persistence. Spatial transcriptomics identifies conserved immune niches in atopic dermatitis lesions, characterized by close co‐localization of CD4+ T cells
Lina Gross +11 more
wiley +1 more source
Th17 but not Th22 cells display pathological behaviour in arthritis [PDF]
Annals of the Rheumatic Diseases, 2012 Background Th17 cells (IL-17+IL-22+) are critically involved in the induction and progression of arthritis. Recently, Th22 cells were discovered, which were characterised by IL-22 expression in the absence of IL-17. However, it remains unclear whether IL-22 and Th22 cells, directly contribute to synovial inflammation.
Jan Piet van Hamburg +5 more
openaire +1 more source
PLoS ONE, 2012 BackgroundT-helper (Th) 22 is involved in the pathogenesis of inflammatory diseases. The roles of Th22 cells in the pathophysiological of ankylosing spondylitis (AS) and rheumatoid arthritis (RA) remain unsettled.
Lei Zhang +11 more
doaj +1 more source
Recruitment and significance of Th22 cells and Th17 cells in malignant ascites
Oncology Letters, 2018 T helper (Th)22 and Th17 cells are implicated in the pathogenesis of a number of types of cancer. However, the function of Th22 and Th17 cells in malignant ascites (MA) remains unknown. The present study aimed at examining the distribution, phenotypes, recruitment, and prognostic value of Th22 and Th17 cells in MA from patients with hepatocellular ...
Xian-Wen, Yang +5 more
openaire +3 more sources
Andrology, EarlyView.ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam +7 more
wiley +1 more source
, 2014 Acute myeloid leukemia (AML) is a hematological tumor in which progress T helper (Th) subsets including Th22, Th17, and Th1 cells play a pivotal role. However, the role of T helper (Th) subsets in the immune pathogenesis of AML remains unclear.
Chuanfang Liu +9 more
core +1 more source
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.Summary Background and Objectives Atopic dermatitis (AD) has a highly variable clinical phenotype and ancestry can contribute to this heterogeneity. This study aims to identify clinical phenotypes of AD in children from diverse ancestry groups, evaluate clinical outcomes and response to treatment, and define phenotypic clusters with potential relevance.
Eugeni Prat‐Colilles +21 more
wiley +1 more source
International Journal of Dermatology, EarlyView.The psoriasis–atopic dermatitis interface: four clinical phenotypes (coexisting, overlapping, biologic‐induced eczema, dupilumab‐induced psoriasis) across 105 patients from two Italian tertiary centers. JAK inhibitors achieved the highest response rates across all phenotypes, reflecting their mechanistic rationale targeting shared JAK‐STAT downstream ...
Michela D'Agostino +8 more
wiley +1 more source
Peripheral Th22 frequency and prevalence of T2D in the subset of obese participants.
, 2014 Peripheral Th22 frequency and prevalence of T2D in the subset of obese participants.
Li Chen (5749) +10 more
core +1 more source