Results 51 to 60 of about 7,483 (199)
Expression of Helper and Regulatory T Cells in Atopic Dermatitis: A Meta-Analysis
Frontiers in Pediatrics, 2022 BackgroundAtopic dermatitis (AD) is a common inflammatory skin disease, with the incidence peaks in infancy. A meta-analysis was performed to assess the levels of T helper type 22 (Th22) cells, T helper type 17 (Th17) cells, interleukin (IL)-17, and ...
Dao-jun Zhang +3 more
doaj +1 more source
Atopic dermatitis: immune deviation, barrier dysfunction, IgE autoreactivity and new therapies
Allergology International, 2017 Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder mostly associated with IgE elevation and skin barrier dysfunction due to decreased filaggrin expression.
Masutaka Furue +6 more
doaj +1 more source
Internal Structure, Kinematics, and Prehistory of Frozen Debris Lobe‐A (FDL‐A), Brooks Range, Alaska
Permafrost and Periglacial Processes, EarlyView.ABSTRACT Frozen Debris Lobe‐A (FDL‐A)—one of hundreds of FDLs in the Brooks Range of northern Alaska—is a slow‐moving landslide in permafrost that has been the subject of research since 2008 due to its close proximity to the Dalton Highway. Here, we synthesize more than a decade's worth of climate and surface measurements of monitored FDLs, and the ...
Margaret M. Darrow +2 more
wiley +1 more source
Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy
Phytotherapy Research, EarlyView.Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee +9 more
wiley +1 more source
Rheumatology &Autoimmunity, EarlyView.This large‐scale retrospective study of 5778 primary Sjögren's disease (SjD) patients, stratified by diagnostic age, defines a distinct clinical and immunological profile for early‐diagnosed (<45 years) disease. We identified early diagnosis as an independent risk factor for hypergammaglobulinemia and interstitial lung disease, underpinned by a ...
Yuan Ning +7 more
wiley +1 more source
AMB Express, 2022 Key points Expression of TNF-α was significantly increased in the PUD group than the gastritis group. Notably, TNF-α expression had a significant positive correlation with the frequency of Th1/Th17/Th22 lymphocytes in the PUD group.
Ghorbanali Rahimian +5 more
doaj +1 more source
Allergy, EarlyView.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter +20 more
wiley +1 more source
Recruitment and significance of Th22 cells and Th17 cells in malignant ascites
Oncology Letters, 2018 T helper (Th)22 and Th17 cells are implicated in the pathogenesis of a number of types of cancer. However, the function of Th22 and Th17 cells in malignant ascites (MA) remains unknown. The present study aimed at examining the distribution, phenotypes, recruitment, and prognostic value of Th22 and Th17 cells in MA from patients with hepatocellular ...
Xian-Wen, Yang +5 more
openaire +3 more sources
Supplementary Material for: Staphylococcal Exotoxins Induce Interleukin 22 in Human Th22 Cells [PDF]
, 2017 Background: We have shown previously that T cells from atopic dermatitis (AD) patients produce more IL-22 upon staphylococcal exotoxin stimulation compared to psoriasis patients and healthy controls.
Satzger I. (3355949) +4 more
core +1 more source
Allergy, EarlyView.IL‐10 producing CCR6+Th‐cells are central memory T‐cells that express ROR‐γt and differentiate to Th17‐cells via an autocrine loop of STAT3‐activating cytokines (preTh17). STAT3‐deficient AD‐HIES patients lack Th17‐ and Tfh17‐cells but retain preTh17‐ and Th1/17‐cells.
Giorgia Moschetti +18 more
wiley +1 more source