Results 11 to 20 of about 1,816,357 (289)

Interleukin-12 p40 secretion by cutaneous CD11c(+) and F4/80(+) cells is a major feature of the innate immune response in mice that develop Th1-mediated protective immunity to Schistosoma mansoni [PDF]

, 2003
Radiation-attenuated (RA) schistosome larvae are potent stimulators of innate immune responses at the skin site of exposure (pinna) that are likely to be important factors in the development of Th1-mediated protective immunity.
Anderson, S, Hogg, K G, Kumkate, S, Mountford, A P   +3 more
core   +2 more sources

Signaling via interleukin-4, receptor alpha chain is required for successful vaccination against schistosomiasis in BALB/c mice [PDF]

, 2001
Radiation-attenuated (RA) schistosome larvae are potent stimulators of innate immune responses at the skin site of exposure (pinna) that are likely to be important factors in the development of Th1-mediated protective immunity.
Anderson S., Anderson S., Anderson S., Artis D., Bancroft A. J., Bancroft A. J., Barner M., Belkaid Y., Brewer J. M., Brombacher F., Coulson P. S., D'Andrea A., de Andres B., Dean D. A., Delgado V., Donaldson D. D., Faquim-Mauro E. L., Galbiati F., Grunig G., Guler M. L., Hilton D. J., Hoffmann K. F., Hsieh C. S., James S. L., Jankovic D., Jankovic D., Jankovic D., King C. L., King C. L., Kopf M., Magram J., Mangold B. L., Matthews D. J., Mattner F., McKenzie G. J., Metwali A., Mohrs M., Mohrs M., Mountford A. P., Mountford A. P., Mountford A. P., Mountford A. P., Mountford A. P., Mountford A. P., Muchamuel T., Nelms K., Noben-Trauth N., Noben-Trauth N., Noben-Trauth N., O'Garra A., Pearce E. J., Reiner S. L., Scott P., Seder R. A., Sher A., Shibuya K., Smythies L. E., Smythies L. E., Street M., Szabo S. J., Urban J. F., Wilson R. A., Wynn T. A., Wynn T. A., Zurawski G.   +64 more
core   +2 more sources

Phase II Trial of IL-12 Plasmid Transfection and PD-1 Blockade in Immunologically Quiescent Melanoma. [PDF]

, 2020
PurposeTumors with low frequencies of checkpoint positive tumor-infiltrating lymphocytes (cpTIL) have a low likelihood of response to PD-1 blockade.
Algazi, Alain P, Andtbacka, Robert HI, Arlauckas, Sean P, Ballesteros-Merino, Carmen, Bannavong, Donna, Bhatia, Shailender, Bifulco, Carlos, Browning, Erica, Canton, David A, Daud, Adil I, Fong, Lawrence, Fox, Bernard A, Francisco, Murray, Gargosky, Sharron, Garris, Christopher, Hermiz, Reneta, Le, Mai, Levine, Lauren P, Oglesby, Arielle, Pierce, Robert, Pittet, Mikael J, Rosenblum, Michael D, Tsai, Katy K, Twitty, Christopher G   +23 more
core   +2 more sources

Serum Levels of Interleukin-12 and Interferon Gamma in Pediatric Tuberculosis: A Clinico-Microbiological Correlation

Journal of Health Science and Medical Research (JHSMR), 2023
Objective: The interleukin-12/interferon-γ (IL-12/IFN-γ) pathway is the most validated cytokine pathway regulating Mycobacterium tuberculosis infection.
Neha Gupta, Bineeta Kashyap, Pooja Dewan, Puneeta Hyanki   +3 more
doaj   +1 more source

The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice [PDF]

, 1996
MRL/MP-lpr/lpr (MRL/lpr) mice develop a spontaneous autoimmune disease. Serum from these mice contained significantly higher concentrations of nitrite/nitrate than serum from age-matched control MRL/MP-+/+ (MRL/+), BALB/c or CBA/6J mice.
Feng, G.J., Huang, F.P., Liew, F.Y., Lindop, G., Stott, D.I.   +4 more
core   +3 more sources

The power and pitfalls of IL-12 [PDF]

Blood, 2012
In this issue of Blood, Pegram and colleagues describe the ability to improve adoptive T-cell therapies by engineering T cells to secrete the potent proinflammatory cytokine IL-12.1 These exciting findings significantly extend previous observations made in a murine melanoma model targeting naturally occurring tumor antigens.2 ...
Sid P, Kerkar, Nicholas P, Restifo
openaire   +2 more sources

Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection. [PDF]

, 1994
Leishmania major are intramacrophage parasites whose eradication requires the induction of T helper 1 (Th1) effector cells capable of activating macrophages to a microbicidal state.
Locksley, RM, Reiner, SL, Stowring, L, Wang, ZE, Zheng, S   +4 more
core   +1 more source

Lipid nanoparticles that deliver IL-12 messenger RNA suppress tumorigenesis in MYC oncogene-driven hepatocellular carcinoma

Journal for ImmunoTherapy of Cancer, 2018
Interleukin-12 (IL-12) is a promising candidate for cancer immunotherapy because of its ability to activate a number of host immune subsets that recognize and destroy cancer cells.
Ian Lai, Srividya Swaminathan, Virginie Baylot, Adriane Mosley, Renumathy Dhanasekaran, Meital Gabay, Dean W. Felsher   +6 more
doaj   +1 more source

The influence of sepsis as a complication after trauma on immune response to injury [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2011
Introduction. Mortality rate in trauma complicated with sepsis is exceeding 50%. Outcome is not determined only by infection or trauma, but also by the intensity of immuno-inflammatory response. Objective.
Šurbatović Maja, Mirković Darko, Radaković Sonja S., Jevtić Miodrag, Filipović Nikola S.   +4 more
doaj   +1 more source

Suggestive evidence of a multi-cytokine resistin pathway in humans and its role on cardiovascular events in high-risk individuals [PDF]

, 2017
In cells and tissues resistin affects IL-1β, IL-6, IL-8, IL-12 and TNF-α expression, thus suggesting the existence of a multi-cytokine "resistin pathway".
Antonucci, Alessandra, Copetti, Massimiliano, De Bonis, Concetta, Di Paola, Rosa, Marucci, Antonella, Menzaghi, Claudia, Ortega Moreno, Lorena, Salvemini, Lucia, Trischitta, Vincenzo   +8 more
core   +1 more source