Results 31 to 40 of about 1,415,739 (335)

Immunogenicity to biological drugs in psoriasis and psoriatic arthritis

Clinics, 2021
Monoclonal antibodies or fusion proteins, defined as biological drugs, have modified the natural history of numerous immune-mediated disorders, allowing the development of therapies aimed at blocking the pathophysiological pathways of the disease ...
Fernando Valenzuela, Rodrigo Flores
doaj   +1 more source

Personalizing IL-23 Inhibitor Therapy in IBD: Current Evidence and Future Directions in Therapeutic Drug Monitoring and Dose Optimization. [PDF]

J Clin Med
Pedicelli A, Bessissow T, Afif W.
europepmc   +3 more sources

Overexpression of interleukin-23, but not interleukin-17, as an immunologic signature of subclinical intestinal inflammation in ankylosing spondylitis [PDF]

, 2009
OBJECTIVE: Subclinical gut inflammation is common in spondylarthritis, but the immunologic abnormalities underlying this process are undefined. Perturbation of the interleukin-23 (IL-23)/Th17 axis has emerged as a fundamental trigger of chronic ...
Becker, Becker, Best, Bettelli, Bettelli, Burton, Chen, Cho, Costa-Rodriguez, De Vos, De Vos, Desreumaux, Duerr, Fujino, Garrett, Harrington, Hugot, Jovanovic, Kastelein, Keshav, Keshav, Kolls, Korn, Kugathasan, Laan, Lala, Langrish, Mielants, Murphy, Ogura, Parronchi, Plevy, Porter, Romagnani, Rudwaleit, Rueda, Teunissen, Uhlig, Van Damme, Van der Linden, Veldhoen   +40 more
core   +1 more source

The effect of periodontal therapy on IL-17 and IL-23 in Gingival Crevicular Fluid (GCF) of patients with severe periodontitis [PDF]

Caspian journal of dental research, 2013
Introduction: Cytokines are the important factors in the progression of periodontal diseases. The aim of this study was to find out the effect of the first phase of the periodontal therapy on the amount of existing IL-17 and IL-23 in gingival crevicular ...
Marzieh Rohaninasab , Mandana Sattari , Horrieh Abedi , Nafise Zarenejad   +3 more
doaj   +2 more sources

Th17-Inducing Cytokines IL-6 and IL-23 Are Crucial for Granuloma Formation during Experimental Paracoccidioidomycosis

Frontiers in Immunology, 2017
Paracoccidioidomycosis (PCM), a chronic granulomatous disease caused by the thermally dimorphic fungus Paracoccidioides brasiliensis and Paracoccidioides lutzii, has the highest mortality rate among systemic mycosis.
Fabrine Sales Massafera Tristão, Fernanda Agostini Rocha, Daniela Carlos, Natália Ketelut-Carneiro, Camila Oliveira Silva Souza, Cristiane Maria Milanezi, João Santana Silva   +6 more
doaj   +1 more source

Elevated testosterone on immunoassay in a patient with metastatic prostate cancer following androgen deprivation therapy and bilateral orchiectomy

Urology Case Reports, 2021
We present the case of an 83-year-old man with metastatic prostate cancer who had testosterone levels reading above castration range despite appropriate medical and surgical castration. Mass spectrometry was performed to confirm presence of testosterone,
Arjun Sarkar, BS, Mohammad Rashid Siddiqui, MD, Richard J. Fantus, MD, Maha Hussain, MD, Joshua A. Halpern, MD, MS, Ashley E. Ross, MD, PhD   +5 more
doaj   +1 more source

IL-17 polarization of MAIT cells is derived from the activation of two different pathways [PDF]

, 2017
MAIT cells are expanded in salivary glands of patients with Sjogren's syndrome and are IL-17 polarized. IL-7 and IL-23 induce IL-17 production activating two different pathways: IL-7 stimulation induces in fact a significant STAT3 and HIF1alpha ...
Alessandro, R., Ciccia, F., Dieli, F., Guggino, G., Liberto, D., Pizzo, M., Saieva, L., Triolo, G.   +7 more
core   +1 more source

Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation. [PDF]

, 2014
OBJECTIVES: Interleukin (IL)-23 has been implicated in the pathogenesis of ankylosing spondylitis (AS). The aim of the study was to clarify the mechanisms underlying the increased IL-23 expression in the gut of AS patients.
Accardo Palumbo,A, ALESSANDRO, Riccardo, Cannizzaro, A, CICCIA, Francesco, Colbert, RA, GIARDINA, Annarita, GUGGINO, Giuliana, RAIMONDO, Stefania, Rizzo,A, TRIOLO, Giovanni   +9 more
core   +1 more source

RNA aptamer delivery through intact human skin [PDF]

, 2018
It is generally recognised that only relatively small molecular weight (typically 100,000-fold) and aptamer integrity was confirmed using an oligonucleotide precipitation assay.
Brown, M. B., Cote-Sierra, J., Demock, K., Donahue, C., Killough, J., Lenn, J. D., Neil, J., Pendergrast, P. S., Rubenstein, D., Smith, S. H., Therrien, J.-P., Tibbetts, C. V., Williams, Adrian   +12 more
core   +3 more sources

Efficacy and safety of IL-23p19 and IL-12/23p40 inhibitors in moderate-to-severe Crohn’s disease: a systematic review and network meta-analysis

Annals of Medicine
Background Interleukin (IL)-23 inhibitors—including IL-23p19 inhibitors (guselkumab, mirikizumab, risankizumab) and the IL-12/23p40 inhibitor ustekinumab—are emerging treatments for Crohn’s disease (CD), but comparative data among them remain limited ...
Motoki Kaneko, Atsushi Sakuraba
doaj   +1 more source