Results 21 to 30 of about 63,292,925 (286)
مجله كليه طب الكندي, 2023 Background: Rheumatoid arthritis (RA) is a chronic and systemic autoimmune disease that is characterized by severe synovial inflammation, cartilage erosion, bone loss, and generalized vasculopathy.
Ahmed Azzam +7 more
doaj +1 more source
The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans [PDF]
, 2011 IL-23 and Th17 cells are key players in tissue immunosurveillance and are implicated in human immune-mediated diseases. Genome-wide association studies have shown that the IL23R R381Q gene variant protects against psoriasis, Crohn's disease and ...
Di Meglio, P +45 more
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IL-23/IL-17 axis and disease activity in systemic lupus erythematosus patients [PDF]
, 2020 Introduction: The latest paradigm proposes that imbalance of Treg and Th17 cells play a significant role in Systemic Lupus Erythematosus (SLE) pathogenesis. The influence of IL-23 and IL-17 on the pathogenesis of SLE remains controversial.
Tri Yanti, Yuliasih, Lita Diah Rahmawati
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Psoriasis: Targets and Therapy, 2022 Matteo Megna, Luca Potestio, Gabriella Fabbrocini, Angelo Ruggiero Section of Dermatology - Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, 80131, ItalyCorrespondence: Angelo Ruggiero, Section of Dermatology ...
Megna M +3 more
doaj
Checks and Balances: IL-23 in the Intestine [PDF]
Immunity, 2010 In this issue of Immunity, Ahern et al. (2010) show that IL-23R signaling in CD4(+) T cells induces effector and suppresses regulatory CD4(+) T cells, which is critical for the development of intestinal, but not systemic, inflammation.
Huber, Samuel, Flavell, Richard A.
openaire +2 more sources
IL-23-mediated ROCK activation promotes Tγδ17 cell migration.
, 2020 (a) IL-7-expanded Tγδ17 cells were stimulated with IL-23 for 6 h in the presence or absence of Y27632 inhibitor or left unstimulated (uns.). Representative histogram shows pSTAT3-Y705 measured by flow cytometry.
Candelas Álvarez-Salamero (8611707) +6 more
core +1 more source
Serum Interleukin 23 and Nitric Oxide in Vitiligo: New insights into the emerging association with VASI Score [PDF]
Zagazig University Medical Journal, 2023 Background: Vitiligo is a depigmentation disease of the skin caused by selective melanocyte degradation. In recent years, vitiligo has become known as an autoimmune disorder.Objectives: Our objective in this study was to determine serum levels of ...
Hagar Bessar +3 more
doaj +1 more source
IL-23 and IL-17 in tuberculosis [PDF]
Cytokine, 2008 Tuberculosis is a chronic disease requiring the constant expression of cellular immunity to limit bacterial growth. The constant expression of immunity also results in chronic inflammation, which requires regulation. While IFN-gamma-producing CD4+ T helper cells (Th1) are required for control of bacterial growth they also initiate and maintain a ...
Shabaana A, Khader, Andrea M, Cooper
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IL-23 in Colitis: Targeting the Progenitors [PDF]
Immunity, 2012 Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract. In this issue of Immunity, Griseri et al. (2012) show that IL-23-induced dysregulation of hematopoietic stem and progenitor cells contributes to the pathogenesis of two IBD models.
Tang, Ce, Iwakura, Yoichiro
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IL‑17F and IL- 23 gene polymorphism in patients with acute myeloid leukemia, an Egyptian study [PDF]
Journal of Bioscience and Applied Research, 2018 Background: Acute myeloid leukemia (AML) is a highly fatal disease occurring due to the proliferation and accumulation of myeloid progenitor cells. Th17 cells had been claimed by many studies to play a role in the development of AML.
Aml Nasr +3 more
doaj +1 more source