Results 21 to 30 of about 1,415,739 (335)

Antitumor and Antimetastatic Activity of IL-23 [PDF]

The Journal of Immunology, 2003
Abstract The structure and T cell stimulatory effects of the recently discovered cytokine IL-23 are similar to, but distinct from, those of IL-12. Although the antitumor activities of IL-12 are well characterized, the effect of IL-23 on tumor growth is not known. In this study, murine CT26 colon adenocarcinoma and B16F1 melanoma cells
Lo, C.-H., Lee, S.-C., Wu, P.-Y., Pan, W.-Y., Su, J., Cheng, C.-W., Roffler, S. R., Chiang, B.-L., Lee, C.-N., Wu, C.-W., Tao, M.-H.   +10 more
openaire   +2 more sources

IL-23 past, present, and future: a roadmap to advancing IL-23 science and therapy. [PDF]

Front Immunol
Interleukin (IL)-23, an IL-12 cytokine family member, is a hierarchically dominant regulatory cytokine in a cluster of immune-mediated inflammatory diseases (IMIDs), including psoriasis, psoriatic arthritis, and inflammatory bowel disease. We review IL-23 biology, IL-23 signaling in IMIDs, and the effect of IL-23 inhibition in treating these diseases ...
Krueger JG, Eyerich K, Kuchroo VK, Ritchlin CT, Abreu MT, Elloso MM, Fourie A, Fakharzadeh S, Sherlock JP, Yang YW, Cua DJ, McInnes IB.   +11 more
europepmc   +7 more sources

Long-Term Efficacy and Safety of Guselkumab for Moderate to Severe Psoriasis: A 3-Year Real-Life Retrospective Study

Psoriasis: Targets and Therapy, 2022
Matteo Megna, Luca Potestio, Gabriella Fabbrocini, Angelo Ruggiero Section of Dermatology - Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, 80131, ItalyCorrespondence: Angelo Ruggiero, Section of Dermatology ...
Megna M, Potestio L, Fabbrocini G, Ruggiero A   +3 more
doaj  

γδTCR regulates production of interleukin-27 by neutrophils and attenuates inflammatory arthritis. [PDF]

, 2018
γδ T cells have been implicated in inflammatory diseases as an important link between the innate and adaptive immune responses, however, their role in inflammatory arthritis remain unclear.
Adamopoulos, Iannis E, Bouchareychas, Laura, Grössinger, Eva M, Kang, Mincheol   +3 more
core   +1 more source

IL‑17F and IL- 23 gene polymorphism in patients with acute myeloid leukemia, an Egyptian study [PDF]

Journal of Bioscience and Applied Research, 2018
Background: Acute myeloid leukemia (AML) is a highly fatal disease occurring due to the proliferation and accumulation of myeloid progenitor cells. Th17 cells had been claimed by many studies to play a role in the development of AML.
Aml Nasr, Hoda El Azizy, Noha El Husseiny, Samar Youssef   +3 more
doaj   +1 more source

CD4 T lymphocyte autophagy is upregulated in the salivary glands of primary Sjögren’s syndrome patients and correlates with focus score and disease activity [PDF]

, 2017
Background: Primary Sjögren’s syndrome (pSS) is a common chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands and peripheral lymphocyte perturbation.
A Bhattacharya, AG Tzioufas, Annacarla Finucci, Antonina Minniti, Aroldo Rizzo, C Alessandri, C Li, C Vitali, C Vitali, CQ Nguyen, Cristiana Barbati, Cristiano Alessandri, D Geem, DJ Klionsky, DM Chisholm, E Astorri, Elena Ortona, Elisa Astorri, F Barone, F Ciccia, F Ciccia, F Ciccia, F Ciccia, F Sallusto, Fabrizio Conti, Francesco Ciccia, Giovanni Triolo, Giuliana Guggino, Guido Valesini, H Nakatogawa, HH Pua, HH Pua, HH Pua, I Tanida, LM Gerland, M Bombardieri, M Bombardieri, M Morgan-Bathke, M Morgan-Bathke, M Moriyama, M Pierdominici, Marina Pierdominici, Marta Vomero, Monica Pendolino, N Mizushima, N Schmitt, R Seror, Riccardo Alessandro, Roberta Priori, S Katsiougiannis, S Romao, Tania Colasanti, TC Adamson 3rd, W Jia, Walter Malorni, XJ Zhou, Y Seo, YZ Gong, Z Yang   +58 more
core   +3 more sources

Structural basis of IL-23 antagonism by an Alphabody protein scaffold [PDF]

, 2014
Protein scaffolds can provide a promising alternative to antibodies for various biomedical and biotechnological applications, including therapeutics.
Bloch, Yehudi, Deroo, Sabrina, Desmet, Johan, Devreese, Bart, Henderikx, Paula, Hettmann, Thore, Lasters, Ignace, Lorent, Eric, Loverix, Stefan, Savvides, Savvas, Somers, Klaartje, Vandenbroucke, Karen, Verstraete, Kenneth, Wen, Yurong   +13 more
core   +1 more source

IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis [PDF]

, 2010
IL-23 is an important molecular driver of Th17 cells and has strong tumor-promoting proinflammatory activity postulated to occur via adaptive immunity.
A. Moller, Awasthi, B. von Scheidt, Cella, D. M. Andrews, G. R. Hill, Haak, Hu, Kaiga, Koebel, Kortylewski, Langowski, Lyakh, M. J. Smyth, M. Oft, M. W. L. Teng, Martin-Orozco, McKenzie, Moore, N. McLaughlin, O'Connor, Oppenheim, Overwijk, Parham, Presky, S. F. Ngiow, Shan, Smyth, Smyth, Street, Tesmer, Trinchieri, Wu, Y. Iwakura, Yen, Yuan, Zhou   +36 more
core   +1 more source

Innate lymphoid cells exhibited IL-17-expressing phenotype in active tuberculosis disease

BMC Pulmonary Medicine, 2021
Background Innate lymphoid cells (ILCs), as an important group of innate immunity, could respond rapidly to Mycobacterium tuberculosis (Mtb) infection.
Linyue Pan, Xiaoli Chen, Xuanqi Liu, Wenjia Qiu, Yunhuan Liu, Weiping Jiang, Yang Zheng, Yan Mou, Wei Xu, Xiangyang Li, Haiyan Ge, Huili Zhu   +11 more
doaj   +1 more source

IL-23 blockers in dermatology

Indian Journal of Drugs in Dermatology, 2021
Interleukin-23 (IL-23) is the key regulatory cytokine in psoriasis, which stimulates differentiation, proliferation, and survival of T-helper 17 (Th17) cells. Specific targeting of IL-23–IL-17 inflammatory pathway has become an effective therapeutic approach to treat psoriasis.
Shrichand G. Parasramani, Manasi Shirolikar   +1 more
openaire   +1 more source