Results 21 to 30 of about 5,569,467 (288)
Cell, 2021 Summary: Interleukin-12 (IL-12) and IL-23 are heterodimeric cytokines produced by antigen presenting cells to regulate the activation and differentiation of lymphocytes and which share IL-12Rβ1 as a receptor signaling subunit.
C. Glassman +10 more
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Checks and Balances: IL-23 in the Intestine [PDF]
Immunity, 2010 In this issue of Immunity, Ahern et al. (2010) show that IL-23R signaling in CD4(+) T cells induces effector and suppresses regulatory CD4(+) T cells, which is critical for the development of intestinal, but not systemic, inflammation.
Huber, Samuel, Flavell, Richard A.
openaire +2 more sources
Psoriasis: Targets and Therapy, 2022 Matteo Megna, Luca Potestio, Gabriella Fabbrocini, Angelo Ruggiero Section of Dermatology - Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, 80131, ItalyCorrespondence: Angelo Ruggiero, Section of Dermatology ...
Megna M +3 more
doaj
Antitumor and Antimetastatic Activity of IL-23 [PDF]
The Journal of Immunology, 2003 Abstract The structure and T cell stimulatory effects of the recently discovered cytokine IL-23 are similar to, but distinct from, those of IL-12. Although the antitumor activities of IL-12 are well characterized, the effect of IL-23 on tumor growth is not known. In this study, murine CT26 colon adenocarcinoma and B16F1 melanoma cells
Lo, C.-H. +10 more
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The IL-17/IL-23 Axis and Its Genetic Contribution to Psoriatic Arthritis
Frontiers in Immunology, 2021 Psoriatic arthritis (PsA) is a chronic inflammatory disease belonging to the family of spondyloarthropathies (SpA). PsA commonly aggravates psoriasis of the skin and frequently manifests as an oligoarthritis with axial skeletal involvement and ...
M. Vecellio +5 more
semanticscholar +1 more source
A non-clinical comparative study of IL-23 antibodies in psoriasis
mAbs, 2021 Four antibodies that inhibit interleukin (IL)-23 are approved for the treatment of moderate-to-severe plaque psoriasis. Here, we present non-clinical data comparing ustekinumab, guselkumab, tildrakizumab and risankizumab with regard to thermostability ...
Li Zhou +19 more
semanticscholar +1 more source
IL‑17F and IL- 23 gene polymorphism in patients with acute myeloid leukemia, an Egyptian study [PDF]
Journal of Bioscience and Applied Research, 2018 Background: Acute myeloid leukemia (AML) is a highly fatal disease occurring due to the proliferation and accumulation of myeloid progenitor cells. Th17 cells had been claimed by many studies to play a role in the development of AML.
Aml Nasr +3 more
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IL-23-IL-17 immune axis: Discovery, Mechanistic Understanding, and Clinical Testing
Nature reviews. Immunology, 2014 Following the discovery of T helper 17 (TH17) cells, the past decade has witnessed a major revision of the TH subset paradigm and substantial progress has been made in deciphering the molecular mechanisms of T cell lineage commitment and function.
S. Gaffen, Renu Jain, A. Garg, D. Cua
semanticscholar +1 more source
Why Inhibition of IL-23 Lacked Efficacy in Ankylosing Spondylitis
Frontiers in Immunology, 2021 The term spondyloarthritis pertains to both axial and peripheral arthritis including ankylosing spondylitis (AS) and psoriatic arthritis (PsA), which is strongly linked to psoriasis and also the arthritis associated with inflammatory bowel disease.
D. McGonagle +3 more
semanticscholar +1 more source
Innate lymphoid cells exhibited IL-17-expressing phenotype in active tuberculosis disease
BMC Pulmonary Medicine, 2021 Background Innate lymphoid cells (ILCs), as an important group of innate immunity, could respond rapidly to Mycobacterium tuberculosis (Mtb) infection.
Linyue Pan +11 more
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