Results 11 to 20 of about 63,292,925 (286)
The role of IL‐23 and the use of IL‐23 inhibitors in psoriatic arthritis [PDF]
Musculoskeletal Care, 2022 AbstractBackgroundPsoriatic arthritis (PsA) is a chronic inflammatory arthritis characterised by musculoskeletal and extra‐articular manifestations, most notably psoriasis. While the underlying pathogenetic mechanisms are not yet fully understood, a central role has been identified for the IL‐23/IL‐17 pathway.ObjectivesWe briefly describe the role of ...
Fragoulis, George E., Siebert, Stefan
core +6 more sources
IL-23 past, present, and future: a roadmap to advancing IL-23 science and therapy [PDF]
Frontiers in ImmunologyInterleukin (IL)-23, an IL-12 cytokine family member, is a hierarchically dominant regulatory cytokine in a cluster of immune-mediated inflammatory diseases (IMIDs), including psoriasis, psoriatic arthritis, and inflammatory bowel disease. We review IL-23 biology, IL-23 signaling in IMIDs, and the effect of IL-23 inhibition in treating these diseases ...
James G. Krueger +13 more
core +7 more sources
Clinical case series: Emergence of psoriatic arthritis during biologic IL-23 pathway inhibition therapy for psoriasis [PDF]
Frontiers in MedicinePsoriasis (PsO) and psoriatic arthritis (PsA) are increasingly recognized as manifestations within the spectrum of psoriatic disease, and emerging observational data suggest that biologic therapy targeting interleukin-23 (IL-23) may reduce the risk of ...
Andrew Z. Li +7 more
doaj +2 more sources
The regulatory mechanism and potential application of IL-23 in autoimmune diseases
Frontiers in Pharmacology, 2022 IL-23 is a heterodimeric pro-inflammatory cytokine secreted by dendritic cells and macrophages that belongs to the IL-12 family. It has pro-inflammatory effects and is a key cytokine and upstream regulatory cytokine involved in protective immune ...
De-Kai Xiong +7 more
doaj +1 more source
Role of the IL-23/IL-17 Pathway in Rheumatic Diseases: An Overview
Frontiers in Immunology, 2021 Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19) and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12).
Claudia Schinocca +6 more
doaj +1 more source
Frontiers in Immunology, 2021 The IL-23/IL-17 axis plays causative roles in the development and progression of systemic lupus erythematosus (SLE). However, it remains unclear if the IL-17RA+ and IL-23R+ T helper (Th) cells populations are associated with the serum IL-17 and IL-23 ...
Aziz Farah Izati +9 more
doaj +1 more source
Frontiers in Immunology, 2022 Psoriasis, a common inflammatory skin disease, is critically dependent on the IL-23/IL-17 cytokine axis. Although immune cell-derived IL-23 is generally associated with the disease pathogenesis, there have been reports of IL-23 production in ...
Young Joon Park +3 more
doaj +1 more source
Frontiers in Immunology, 2022 Axial spondyloarthritis (axSpA) is comprised of ankylosing spondylitis (AS) and non-radiographic axSpA. In recent years, the involvement of the interleukin (IL)-23/IL-17 axis in the pathophysiology of axSpA has been widely proposed.
Hua Zhang, Han-Lei Jiang, Sheng-Ming Dai
doaj +1 more source
The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside
Frontiers in Immunology, 2020 Interleukin-17 (IL-17) is an essential proinflammatory cytokine, which is mainly secreted by the CD4+ helper T cells (Th17 cells) and subsets of innate lymphoid cells.
Taoming Liu +7 more
doaj +1 more source
ASPECTS OF BIODETERIORATION OF LAPIDEOUS SUBMERGED ARTEFACTS: 3D METHODOLOGIES APPLICATION [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2015 Submerged stone archaeological artefacts are bioeroded by endolithic microbiota (cyanobacteria, algae and fungi) and macroborers (Porifera, Bivalvia and Sipuncula).
S. Ricci, F. Antonelli, C. Sacco Perasso
doaj +1 more source