Results 11 to 20 of about 5,569,467 (288)
ASPECTS OF BIODETERIORATION OF LAPIDEOUS SUBMERGED ARTEFACTS: 3D METHODOLOGIES APPLICATION [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2015 Submerged stone archaeological artefacts are bioeroded by endolithic microbiota (cyanobacteria, algae and fungi) and macroborers (Porifera, Bivalvia and Sipuncula).
S. Ricci, F. Antonelli, C. Sacco Perasso
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مجله كليه طب الكندي, 2023 Background: Rheumatoid arthritis (RA) is a chronic and systemic autoimmune disease that is characterized by severe synovial inflammation, cartilage erosion, bone loss, and generalized vasculopathy.
Ahmed Azzam +7 more
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The Role of IL-23 in the Pathogenesis and Therapy of Inflammatory Bowel Disease
International Journal of Molecular Sciences, 2023 Interleukin-23 (IL-23) is a proinflammatory cytokine produced mainly by macrophages and antigen-presenting cells (APCs) after antigenic stimulation. IL-23 plays a significant role as a mediator of tissue damage.
Aleksandra Korta +2 more
semanticscholar +1 more source
Human IL-23 is essential for IFN-γ-dependent immunity to mycobacteria
Science immunology, 2023 Patients with autosomal recessive (AR) IL-12p40 or IL-12Rβ1 deficiency display Mendelian susceptibility to mycobacterial disease (MSMD) due to impaired IFN-γ production and, less commonly, chronic mucocutaneous candidiasis (CMC) due to impaired IL-17A/F ...
Quentin Philippot +57 more
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IL-23 and IL-17 in tuberculosis [PDF]
Cytokine, 2008 Tuberculosis is a chronic disease requiring the constant expression of cellular immunity to limit bacterial growth. The constant expression of immunity also results in chronic inflammation, which requires regulation. While IFN-gamma-producing CD4+ T helper cells (Th1) are required for control of bacterial growth they also initiate and maintain a ...
Shabaana A, Khader, Andrea M, Cooper
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IL-23 in Colitis: Targeting the Progenitors [PDF]
Immunity, 2012 Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract. In this issue of Immunity, Griseri et al. (2012) show that IL-23-induced dysregulation of hematopoietic stem and progenitor cells contributes to the pathogenesis of two IBD models.
Tang, Ce, Iwakura, Yoichiro
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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Journal of Experimental Medicine, 2005 Interleukin (IL)-23 is a heterodimeric cytokine composed of a unique p19 subunit, and a common p40 subunit shared with IL-12. IL-12 is important for the development of T helper (Th)1 cells that are essential for host defense and tumor suppression.
C. Langrish +8 more
semanticscholar +1 more source
Blockade of IL-23: What is in the Pipeline?
Journal of Crohn's & Colitis, 2022 Interleukin 23 [IL-23] plays a key role in the pathogenesis of both Crohn’s disease [CD] and ulcerative colitis [UC], promoting a Th17 cell-related immune response.
T. Parigi, M. Iacucci, Subrata Ghosh
semanticscholar +1 more source
Neuron, 2021 SUMMARY Although sex dimorphism is increasingly recognized as an important factor in pain, female-specific pain signaling is not well-studied. Here we report that administration of IL-23 produces mechanical pain (mechanical allodynia) in female, but not ...
Xin Luo +16 more
semanticscholar +1 more source
The role of IL-23 in the immunopathogenesis of psoriasis [PDF]
F1000 Biology Reports, 2010 In just 10 years from its discovery in 2000, interleukin-23 has quickly moved from being recognized as a pro-inflammatory cytokine to a key player and potential therapeutic target in psoriasis.
Meglio, Paola Di, Nestle, Frank O
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