The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans [PDF]
, 2011 IL-23 and Th17 cells are key players in tissue immunosurveillance and are implicated in human immune-mediated diseases. Genome-wide association studies have shown that the IL23R R381Q gene variant protects against psoriasis, Crohn's disease and ...
Di Meglio, P +34 more
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IL-23/IL-17 axis and disease activity in systemic lupus erythematosus patients [PDF]
, 2020 Introduction: The latest paradigm proposes that imbalance of Treg and Th17 cells play a significant role in Systemic Lupus Erythematosus (SLE) pathogenesis. The influence of IL-23 and IL-17 on the pathogenesis of SLE remains controversial.
Tri Yanti, Yuliasih, Lita Diah Rahmawati
core +1 more source
Differential regulation of interleukin-17 and interferon-y production in inflammatory bowel disease [PDF]
, 2010 PhDBackground and Aims. Interleukin (IL)-17 is now known to be involved in a number of chronic inflammatory disorders. However, the mechanisms regulating its production in inflammatory bowel disease (IBD) are still unclear. Methods.
Rovedatti, Laura
core +4 more sources
IL-23-mediated ROCK activation promotes Tγδ17 cell migration.
, 2020 (a) IL-7-expanded Tγδ17 cells were stimulated with IL-23 for 6 h in the presence or absence of Y27632 inhibitor or left unstimulated (uns.). Representative histogram shows pSTAT3-Y705 measured by flow cytometry.
Candelas Álvarez-Salamero (8611707) +6 more
core +1 more source
IL‑17F and IL- 23 gene polymorphism in patients with acute myeloid leukemia, an Egyptian study [PDF]
Journal of Bioscience and Applied Research, 2018 Background: Acute myeloid leukemia (AML) is a highly fatal disease occurring due to the proliferation and accumulation of myeloid progenitor cells. Th17 cells had been claimed by many studies to play a role in the development of AML.
Aml Nasr +3 more
doaj +1 more source
Innate lymphoid cells exhibited IL-17-expressing phenotype in active tuberculosis disease
BMC Pulmonary Medicine, 2021 Background Innate lymphoid cells (ILCs), as an important group of innate immunity, could respond rapidly to Mycobacterium tuberculosis (Mtb) infection.
Linyue Pan +11 more
doaj +1 more source
The effect of periodontal therapy on IL-17 and IL-23 in Gingival Crevicular Fluid (GCF) of patients with severe periodontitis [PDF]
Caspian journal of dental research, 2013 Introduction: Cytokines are the important factors in the progression of periodontal diseases. The aim of this study was to find out the effect of the first phase of the periodontal therapy on the amount of existing IL-17 and IL-23 in gingival crevicular ...
Marzieh Rohaninasab +3 more
doaj +2 more sources
Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and interleukin-1 [PDF]
, 2010 If insufficiently treated, Lyme borreliosis can evolve into an inflammatory disorder affecting skin, joints, and the CNS. Early innate immunity may determine host responses targeting infection. Thus, we sought to characterize the immediate cytokine storm
Nicole Darsow +40 more
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Trypanosomiasis-induced Th17-like immune responses in carp [PDF]
, 2010 Background - In mammalian vertebrates, the cytokine interleukin (IL)-12 consists of a heterodimer between p35 and p40 subunits whereas interleukin-23 is formed by a heterodimer between p19 and p40 subunits.
B M Lidy Verburg-van Kemenade +36 more
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Frontiers in Immunology, 2017 Paracoccidioidomycosis (PCM), a chronic granulomatous disease caused by the thermally dimorphic fungus Paracoccidioides brasiliensis and Paracoccidioides lutzii, has the highest mortality rate among systemic mycosis.
Fabrine Sales Massafera Tristão +6 more
doaj +1 more source