Results 11 to 20 of about 1,415,739 (335)
The role of IL‐23 and the use of IL‐23 inhibitors in psoriatic arthritis [PDF]
Musculoskeletal Care, 2022 AbstractBackgroundPsoriatic arthritis (PsA) is a chronic inflammatory arthritis characterised by musculoskeletal and extra‐articular manifestations, most notably psoriasis. While the underlying pathogenetic mechanisms are not yet fully understood, a central role has been identified for the IL‐23/IL‐17 pathway.ObjectivesWe briefly describe the role of ...
Fragoulis, George E., Siebert, Stefan
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ASPECTS OF BIODETERIORATION OF LAPIDEOUS SUBMERGED ARTEFACTS: 3D METHODOLOGIES APPLICATION [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2015 Submerged stone archaeological artefacts are bioeroded by endolithic microbiota (cyanobacteria, algae and fungi) and macroborers (Porifera, Bivalvia and Sipuncula).
S. Ricci, F. Antonelli, C. Sacco Perasso
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مجله كليه طب الكندي, 2023 Background: Rheumatoid arthritis (RA) is a chronic and systemic autoimmune disease that is characterized by severe synovial inflammation, cartilage erosion, bone loss, and generalized vasculopathy.
Ahmed Azzam +7 more
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IL-23 and IL-17 in tuberculosis [PDF]
Cytokine, 2008 Tuberculosis is a chronic disease requiring the constant expression of cellular immunity to limit bacterial growth. The constant expression of immunity also results in chronic inflammation, which requires regulation. While IFN-gamma-producing CD4+ T helper cells (Th1) are required for control of bacterial growth they also initiate and maintain a ...
Shabaana A, Khader, Andrea M, Cooper
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IL-23 in Colitis: Targeting the Progenitors [PDF]
Immunity, 2012 Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract. In this issue of Immunity, Griseri et al. (2012) show that IL-23-induced dysregulation of hematopoietic stem and progenitor cells contributes to the pathogenesis of two IBD models.
Tang, Ce, Iwakura, Yoichiro
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Checks and Balances: IL-23 in the Intestine [PDF]
Immunity, 2010 In this issue of Immunity, Ahern et al. (2010) show that IL-23R signaling in CD4(+) T cells induces effector and suppresses regulatory CD4(+) T cells, which is critical for the development of intestinal, but not systemic, inflammation.
Huber, Samuel, Flavell, Richard A.
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Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis [PDF]
, 2009 Objectives Th17 cells are an effector T-cell population that plays a role in chronic inflammatory conditions and is dependent on IL-23 for their survival and expansion. More recently, a genetic association was discovered between polymorphisms in the gene
De Keyser, Filip +8 more
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Interleukin (IL)–12 and IL-23 Are Key Cytokines for Immunity against Salmonella in Humans [PDF]
, 2004 Patients with inherited deficiency of the interleukin (IL)–12/IL-23–interferon (IFN)–g axis show increased susceptibility to invasive disease caused by the intramacrophage pathogens salmonellae and mycobacteria. We analyzed data on 154 patients with such
Casanova, Jean-Laurent +10 more
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The role of IL-23 in the immunopathogenesis of psoriasis [PDF]
F1000 Biology Reports, 2010 In just 10 years from its discovery in 2000, interleukin-23 has quickly moved from being recognized as a pro-inflammatory cytokine to a key player and potential therapeutic target in psoriasis.
Meglio, Paola Di, Nestle, Frank O
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NCR+ ILC3 maintain larger STAT4 reservoir via T-BET to regulate type 1 features upon IL-23 stimulation in mice [PDF]
, 2018 Innate lymphoid cells (ILCs) producing IL-22 and/or IL-17, designated as ILC3, comprise a heterogeneous subset of cells involved in regulation of gut barrier homeostasis and inflammation.
Kanno, Yuka +7 more
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