Results 41 to 50 of about 63,292,925 (286)

Efficacy and safety of IL-23p19 and IL-12/23p40 inhibitors in moderate-to-severe Crohn’s disease: a systematic review and network meta-analysis

Annals of Medicine
Background Interleukin (IL)-23 inhibitors—including IL-23p19 inhibitors (guselkumab, mirikizumab, risankizumab) and the IL-12/23p40 inhibitor ustekinumab—are emerging treatments for Crohn’s disease (CD), but comparative data among them remain limited ...
Motoki Kaneko, Atsushi Sakuraba
doaj   +1 more source

Il Fibroblast Growth Factor-23 (FGF-23)

Giornale di Clinica Nefrologia e Dialisi, 2018
Negli ultimi due decenni, l'identificazione delle proprietà biologiche del Fibroblast Growth Factor 23 (FGF23) ha notevolmente ampliato le conoscenze sulla regolazione endocrina e paracrina dell'omeostasi dei fosfati e sulle relazioni intercorrenti tra ...
D. Rendina, G. De Filippo, R. Muscariello, F. De Pascale, P. Strazzullo   +4 more
doaj   +1 more source

Elevated testosterone on immunoassay in a patient with metastatic prostate cancer following androgen deprivation therapy and bilateral orchiectomy

Urology Case Reports, 2021
We present the case of an 83-year-old man with metastatic prostate cancer who had testosterone levels reading above castration range despite appropriate medical and surgical castration. Mass spectrometry was performed to confirm presence of testosterone,
Arjun Sarkar, BS, Mohammad Rashid Siddiqui, MD, Richard J. Fantus, MD, Maha Hussain, MD, Joshua A. Halpern, MD, MS, Ashley E. Ross, MD, PhD   +5 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

IL-23 induces RLC-S20 phosphorylation in TCRγδ IL-23R+ cells.

, 2020
(a) Il23r-gfp reporter mice were treated with IMQ or left untreated (Ctrl) for 5 days. Lymph node cells were processed for analysis of IL-23R/GFP expression by flow cytometry.
Candelas Álvarez-Salamero (8611707), Gloria Pastor-Fernández (8611710), Isabel R. Mariblanca (8611713), Jesús Pino (293477), Raquel Castillo-González (827266), María N. Navarro (8611719), Danay Cibrian (8611716)   +6 more
core   +1 more source

Analysis of IL12B gene variants in inflammatory bowel disease [PDF]

, 2012
IL12B encodes the p40 subunit of IL-12, which is also part of IL-23. Recent genome-wide association studies identified IL12B and IL23R as susceptibility genes for inflammatory bowel disease (IBD).
Darina Czamara, Seiderer, J., Seiderer Julia, Ochsenkühn, Thomas, Fries, C., Julia Seiderer (107820), Beigel, F., Wagner, Johanna, Glas, J., Cornelia Tillack (174718), Friedrich, Matthias, Christian Steib (174731), Czamara, D., Diegelmann Julia, Jürgen Glas (107816), Fries Christoph, Tillack, Cornelia, Friedrich Matthias, Steib Christian, Stallhofer, Johannes, Torsten Olszak (107835), Brand, Stephan, Göke, B., Florian Beigel (174724), Brand Stephan, Thomas Ochsenkühn, Olszak Torsten, Beigel, Florian, Matthias Friedrich (174721), Thomas Ochsenkühn (174734), Stallhofer, J., Ochsenkühn, T., Johannes Stallhofer, Matthias Friedrich, Wetzke, M., Darina Czamara (107824), Stephan Brand (107861), Cornelia Tillack, Julia Diegelmann, Beigel Florian, Steib, Christian, Göke, Burkhard, Wetzke Martin, Fries, Christoph, Wagner, J., Friedrich, M., Seiderer, Julia, Glas, Jürgen, Diegelmann, J., Burkhard Göke (109829), Christoph Fries, Ochsenkühn Thomas, Wagner Johanna, Martin Wetzke, Burkhard Göke, Göke Burkhard, Christian Steib, Stephan Brand, Brand, S., Steib, C., Czamara, Darina, Martin Wetzke (107833), Stallhofer Johannes, Julia Diegelmann (107830), Jürgen Glas, Johanna Wagner (174709), Tillack Cornelia, Johanna Wagner, Wetzke, Martin, Czamara Darina, Diegelmann, Julia, Christoph Fries (174714), Johannes Stallhofer (174728), Glas Jürgen, Torsten Olszak, Olszak, T., Florian Beigel, Julia Seiderer, Olszak, Torsten, Tillack, C.   +79 more
core   +2 more sources

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

IL-27 regulates IL-18 binding protein in skin resident cells [PDF]

, 2012
IL-18 is an important mediator involved in chronic inflammatory conditions such as cutaneous lupus erythematosus, psoriasis and chronic eczema. An imbalance between IL-18 and its endogenous antagonist IL-18 binding protein (BP) may account for increased ...
Wittmann, M, Miriam Wittmann, Werfel, Thomas, Bachmann, M, Doble, Rosella, Muehl, H, Thomas Werfel, Doble Rosella, Pfeilschifter, Josef (Prof. Dr.), Doble, R, Heiko Mühl, Mühl Heiko, Malte Bachmann, Wittmann Miriam, Pfeilschifter, J, Wittmann, Miriam, Bachmann Malte, Werfel, T, Josef Pfeilschifter, Werfel Thomas, Bachmann, Malte, Mühl, Heiko, Rosella Doble, Pfeilschifter Josef   +23 more
core   +2 more sources

Biologic Treatments of Psoriasis: An Update for the Clinician

Biologics: Targets & Therapy, 2021
Nicholas D Brownstone, Julie Hong, Megan Mosca, Edward Hadeler, Wilson Liao, Tina Bhutani, John Koo University of California, San Francisco, Department of Dermatology, Psoriasis and Skin Treatment Center, San Francisco, CA, USACorrespondence: Nicholas D ...
Brownstone ND, Hong J, Mosca M, Hadeler E, Liao W, Bhutani T, Koo J   +6 more
doaj  

Expanding Diversity in Molecular Structures and Functions of the IL-6/IL-12 Heterodimeric Cytokine Family

Frontiers in Immunology, 2016
The interleukin (IL)-6/IL-12 family cytokines have pleiotropic functions and play critical roles in multiple immune responses. This cytokine family has very unique characteristics in that they are composed of two distinct subunits forming a heterodimer ...
Hideaki Hasegawa, Izuru Mizoguchi, Yukino Chiba, Mio Ohashi, Mingli Xu, Takayuki Yoshimoto   +5 more
doaj   +1 more source