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Molecular cancer prevention: Intercepting disease
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
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Immunological role of IL-25 on gut-dwelling helminths
Gashaw Azanaw Amare +15 more
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IL-25 (IL-17E) in epithelial immunology and pathophysiology
Journal of Allergy and Clinical Immunology, 2021IL-25, also known as IL-17E, is a unique cytokine of the IL-17 family. Indeed, IL-25 exclusively was shown to strongly induce expression of the cytokines associated with type 2 immunity. Although produced by several types of immune cells, such as T cells, dendritic cells, or group 2 innate lymphoid cells, a vast amount of IL-25 derives from epithelial ...
Borowczyk, Julia +3 more
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IL-25 and IL-25 Receptor Expression on Eosinophils from Subjects with Allergic Asthma
International Archives of Allergy and Immunology, 2013<b><i>Background:</i></b> Allergic asthma is an inflammatory airway disease in which Th2 cytokines play an important role. Epithelial-derived interleukin (IL)-25 has been suggested to be important in the maintenance of Th2-type responses.
Tang, Wei +6 more
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Topical Corticosteroids Decrease IL-25 Expression by Immunohistochemistry
ORL, 2019<b><i>Background:</i></b> Interleukin-25 (IL-25) is an important contributing factor in the pathogenesis of allergic rhinitis. It leads to increasing peripheral and infiltrating eosinophilia as well as serum IgE, IgG, and Th2 cytokines (IL-4, IL-5, IL-13), which are responsible for the allergic symptoms. Intranasal steroids (INS)
Hany Samir, Moustafa +5 more
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Journal of Allergy and Clinical Immunology, 2011
IL-25 is thought to participate in allergic inflammation by propagating T(h)2-type responses.To address the hypothesis that allergen provocation increases expression of IL-25 and its receptor IL-25R in the asthmatic bronchial mucosa and skin dermis of atopic subjects.Sequential single and double immunostaining was used to evaluate the numbers and ...
Corrigan, Chris J. +12 more
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IL-25 is thought to participate in allergic inflammation by propagating T(h)2-type responses.To address the hypothesis that allergen provocation increases expression of IL-25 and its receptor IL-25R in the asthmatic bronchial mucosa and skin dermis of atopic subjects.Sequential single and double immunostaining was used to evaluate the numbers and ...
Corrigan, Chris J. +12 more
openaire +3 more sources
Say it isn’t pso: IL-25 drives skin inflammation
Science Immunology, 2018IL-25 from keratinocytes mediates skin inflammation in psoriasis.
Lokesh A, Kalekar, Michael D, Rosenblum
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IL-25, another promoter of allergy
2009Although there have been significant insights into the mechanism underlying the initiation of type 1 immune response, how type 2-mediated pathology especially allergic diseases is developed remains unclear. Cytokine environment is important in shaping and initiating Th2 responses. IL-25, also called IL-17E, belongs to the IL-17 family but, unlike other
Pornpimon Angkasekwinai, Chen Dong
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