Results 111 to 120 of about 2,340,150 (306)

IL-13Rα2 is a Glioma-Restricted Receptor for Interleukin-13

open access: yesNeoplasia: An International Journal for Oncology Research, 2002
We have found that binding sites for interleukin-13. ( IL13) are overexpressed in a vast majority of high-grade astrocytomas. (HGAs). These binding sites for IL-13 are distinct from the physiological receptor in that it does not bind IL-4.
Akiva Mintz   +4 more
doaj   +1 more source

Monoclonal antibody blockade of IL-2 receptor α during lymphopenia selectively depletes regulatory T cells in mice and humans.

open access: yesBlood, 2011
Lymphodepletion augments adoptive cell transfer during antitumor immunotherapy, producing dramatic clinical responses in patients with malignant melanoma.
D. Mitchell   +15 more
semanticscholar   +1 more source

Monoclonal antibodies in type 2 asthma : a systematic review and network meta-analysis [PDF]

open access: yes, 2019
Since novel treatments to target eosinophilic inflammation in Type 2 asthma are emerging, we aimed to evaluate and meta-analyze the efficacy of monoclonal antibodies to reduce exacerbation rate.
De Feyter, Silke   +4 more
core   +1 more source

PIM kinase control of CD8 T cell protein synthesis and cell trafficking

open access: yeseLife
Integration of kinase signalling networks co-ordinates the transcriptional, translational, and metabolic changes required for T cell activation and differentiation. This study explores the role of the Serine/Threonine kinases PIM1 and PIM2 in controlling
Julia M Marchingo   +3 more
doaj   +1 more source

Protein connectivity in chemotaxis receptor complexes [PDF]

open access: yes, 2015
The chemotaxis sensory system allows bacteria such as Escherichia coli to swim towards nutrients and away from repellents. The underlying pathway is remarkably sensitive in detecting chemical gradients over a wide range of ambient concentrations. Interactions among receptors, which are predominantly clustered at the cell poles, are crucial to this ...
arxiv   +1 more source

Interleukin 2 and stimulator lymphoblastoid cells will induce human thymocytes to bind and kill K562 targets. [PDF]

open access: yes, 1982
Human thymocytes cultured in the presence of IL-2 and an irradiated B cell line became cytotoxic to K562 target cells. Thymocytes cultured alone or with only IL-2 exhibited almost no killing, but thymocytes cultured in the presence of stimulator cells ...
Golub, SH, Sidell, N, Torten, M
core  

Multiple Routes for Glutamate Receptor Trafficking: Surface Diffusion and Membrane Traffic Cooperate to Bring Receptors to Synapses [PDF]

open access: yesScience's STKE (electronic resource) : signal transduction knowledge environment 327 (21/03/2006) 13, 2007
Trafficking of glutamate receptors into and out of synapses is critically involved in the plasticity of excitatory synaptic transmission. Endocytosis and exocytosis of receptors have initially been thought to account alone for this trafficking. However, membrane proteins also traffic through surface lateral diffusion in the plasma membrane. We describe
arxiv  

Clinical Value of Neopterin In Infectious Complications

open access: yesPteridines, 1999
Neopterin, a pteridine intermediate metabolite in the biopterine synthetic pathway, is synthesized and secreted by monocyte/macrophages upon stimulation, mainly by gamma-interferon by activated T cells.
Iwagaki Hiromi   +5 more
doaj   +1 more source

Dependence of interleukin-10 quantitative level from genetic polymorphism of toll-like receptors 2 (rs 5743708) in patients with herpes zoster

open access: yesJournal of Education, Health and Sport, 2019
Background. Herpes zoster is urgent problem of the present time, due to increased incidence of severe course with complications in immunocompetent persons, which leads to decrease quality of life and disability.
N. V. Onishchenko, O. V. Riabokon
doaj   +1 more source

Antibodies to common leukocyte antigen p220 influence human T cell proliferation by modifying IL 2 receptor expression.

open access: yesJournal of Immunology, 1985
The p220 antigen is found on the high m.w. form of the T200 common leukocyte antigen family. Although T200 monoclonal antibodies (MAb) react with all hematopoietic cells, p220 MAb react only with B cells, NK cells, about 50% of CD4+ T helper cells, and ...
J. Ledbetter   +5 more
semanticscholar   +1 more source

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