A great disturbance in the force: IL-2 receptor defects disrupt immune homeostasis. [PDF]
Curr Opin Pediatr, 2022 Hernandez JD, Hsieh EWY.
europepmc +1 more source
Induction in Pancreas Transplantation: T-cell Depletion Versus IL-2 Receptor Blockade. [PDF]
Transplant Direct, 2022 Aziz F +4 more
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Targeting Human IL-2 Receptors for Diagnosis and Therapy
Experimental Biology and Medicine, 1994 The high-affinity interleukin-2 receptor (IL-2R) is a multichain receptor with at least three IL-2 binding chains: IL-2R alpha (55 kDa) bound by the monoclonal antibody anti-Tac, IL-2R beta (75 kDa) and Il-2R gamma (64 kDa). The IL-2R alpha also exists as a naturally occurring soluble molecule (sIL-2R alpha). We target the IL-2R for immune intervention
Carole C. Kurman, David L. Nelson
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SUSD2 suppresses CD8+ T cell antitumor immunity by targeting IL-2 receptor signaling. [PDF]
Nat Immunol, 2022 Zhao B +18 more
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Mechanisms of human T cell response to mitogens: IL 2 induces IL 2 receptor expression and proliferation but not IL 2 synthesis in PHA-stimulated T cells. [PDF]
, 1985 D Katzen +6 more
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Human IL-2 Receptor α Chain Deficiency [PDF]
Pediatric Research, 2000 Profound cellular immunodeficiency occurs as the result of mutations in proteins involved in both the differentiation and function of mature lymphoid cells. We describe here a novel human immune aberration arising from a truncation mutation of the IL-2 receptor alpha chain (CD25), a subunit of the tripartite high-affinity receptor for IL-2.
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Distinctive growth requirements and gene expression patterns distinguish progenitor B cells from pre-B cells. [PDF]
, 1993 Long-term bone marrow cultures have been useful in determining gene expression patterns in pre-B cells and in the identification of cytokines such as interleukin 7 (IL-7).
Faust, EA +4 more
core
Cells, 2019 Helicobacter pylori colonizes human gastric epithelial cells and contributes to the development of several gastrointestinal disorders. Interleukin (IL)-33 is involved in various immune responses, with reported proinflammatory and anti-inflammatory ...
Chia-Jung Kuo +8 more
doaj +1 more source
IL-2 receptor engineering enhances regulatory T cell function suppressed by calcineurin inhibitor. [PDF]
Am J Transplant, 2022 Hirai T +9 more
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Steroid Receptors and Vertebrate Evolution [PDF]
arXiv, 2019 Considering that life on earth evolved about 3.7 billion years ago, vertebrates are young, appearing in the fossil record during the Cambrian explosion about 542 to 515 million years ago. Results from sequence analyses of genomes from bacteria, yeast, plants, invertebrates and vertebrates indicate that receptors for adrenal steroids (aldosterone ...
arxiv