Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source
Steroid sensitivity of thymocyte subpopulations during intrathymic differentiation. Effects of 17 beta-estradiol and dexamethasone on subsets expressing T cell antigen receptor or IL-2 receptor. [PDF]
, 1989 Isabella Screpanti +8 more
openalex +1 more source
The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses. [PDF]
, 2019 T helper 17 cells (Th17) are critical for fighting infections at mucosal surfaces; however, they have also been found to contribute to the pathogenesis of multiple autoimmune diseases and have been targeted therapeutically.
Anderson, Mark S +6 more
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Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi +26 more
wiley +1 more source
Journal of Pharmacological Sciences, 2006 UTP causes interleukin (IL)-6 production via mRNA expression through P2Y2/P2Y4 receptors in human HaCaT keratinocytes. In the present study, we analyzed the mechanism of UTP-induced IL-6 production in these cells.
Daisaku Kobayashi +2 more
doaj
Selective expansion of regulatory T cells using an orthogonal IL-2/IL-2 receptor system facilitates transplantation tolerance. [PDF]
J Clin Invest, 2021 Hirai T +16 more
europepmc +1 more source
Structure-function relationships for the IL 2-receptor system. IV. Analysis of the sequence and ligand-binding properties of soluble Tac protein. [PDF]
, 1987 R J Robb, Rusty Kutny
openalex +1 more source
Molecular Oncology, EarlyView.TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam +9 more
wiley +1 more source
The characteristics of a monoclonal antibody that binds specifically to rat T lymphoblasts and inhibits IL 2 receptor functions. [PDF]
, 1983 H Osawa, Tibor Diamantstein
openalex +1 more source
A krónikus hepatitis C vírus infekcióhoz társuló elégtelen celluláris immunválasz pathogenezise = Pathogenesis of the impaired cellular immunity in chronic HCV hepatitis [PDF]
, 2009 A krónikus hepatitis C virus infekcióhoz társuló elégtelen celluláris immunválasz pathogenezise 1. Krónikus HCV hepatitisesekben észlelt elégtelen celluláris immunválasz hátterében emelkedett regulatorikus T sejt arányt, csökent CD3-CD56dim+ NK sejt
Barakonyi, Aliz +3 more
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