Results 161 to 170 of about 1,399,966 (352)

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

IL-2 receptor; IL-2 receptor β-chain (IL2RB; CD122) [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

IL-12p40 Homodimer Ameliorates Experimental Autoimmune Arthritis [PDF]

IL-23 is the key cytokine that induces the expansion of Th17 cells. It is composed of p19 and p40 subunits of IL-12. The p40 subunit binds competitively to the receptor of IL-23 and blocks its activity.
Cho, ML, Heo, YJ, Ju, JH, Jung, YO, Kang, CM, Kim, DJ, Kim, HY, Kwok, SK, Lee, SY, Moon, YM, Oh, HJ, Park, SH, Park, SJ, Sung, YC, Yang, SH   +14 more
core   +1 more source

Characterization of an interleukin-2 (IL-2)-induced tyrosine phosphorylated 116-kDa protein associated with the IL-2 receptor beta-subunit.

, 1993
Robert A. Kirken, Hallgeir Rui, Gerald A. Evans, William L. Farrar   +3 more
openalex   +1 more source

A Proteomic Analysis Reveals That Snail Regulates the Expression of the Nuclear Orphan Receptor Nuclear Receptor Subfamily 2 Group F Member 6 (Nr2f6) and Interleukin 17 (IL-17) to Inhibit Adipocyte Differentiation * [PDF]

, 2014
Alberto Peláez‐García, Rodrigo Barderas, Raquel Batlle, Rosa Viñas-Castells, Rubén A. Bartolomé, Sofía Torres, Marta Mendes, María López-Lucendo, Rocco Mazzolini, Félix Bonilla, Antonio Garcı́a de Herreros, J. Ignacio Casal   +11 more
openalex   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A Commentary on: Production and characterization of monoclonal antibodies to human interleukin-2: Strategies and tactics by Smith, K.A., Favata, M.F., and Oroszlan, S. J. Immunol. (1983) 131: 1808-1815.

Frontiers in Immunology, 2015
Kendall Arthur Smith
doaj   +1 more source

566 MDK-202: An empirically-designed peptidyl agonist of the IL-2/15βγc receptor, devoid of Rα interaction, unrelated to IL-2 or IL-15, and fused to an Fc-domain for PK enhancement

, 2020
William J. Dower, Steven E. Cwirla, Blake Williams, Praechompoo Pongtornpipat, Prarthana Joshi, Sandra Wang, Alice Bakker, Michael Needels, Ronald W. Barrett   +8 more
openalex   +1 more source

Antagonism of cannabinoid receptor 2 pathway suppresses IL-6-induced immunoglobulin IgM secretion [PDF]

, 2014
Rentian Feng, Christine Milcarek, Xiang‐Qun Xie   +2 more
openalex   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source