Biological significance of soluble IL-2 receptor [PDF]
Mediators of Inflammation, 1993 A NUMBER of receptors for growth factors and differentiation antigens have been found to be secreted or released by cells. Following mononuclear cell (MNC) activation and interleukin-2 receptor (IL-2R) expression, a soluble form of the Alpha;-chain of IL-
Calogero Caruso +4 more
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Bypassing the cytokine sink: IL-2-independent IL-2 receptor signaling. [PDF]
Mol Ther, 2023 Luetkens T.
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The IL-2/IL-2-Receptor Complex in the Maturation of Rat T-Cell Progenitors [PDF]
Clinical and Developmental Immunology, 1998 On the basis of both the interleukin‐2‐receptor (IL‐2R) α‐chain expression on 16‐day‐old fetal rat thymocytes and the occurrence of interleukin‐2 (IL‐2) mRNA‐containing cells early during rat thymus ontogeny, we have investigated the possible role of IL‐2/IL‐2R complex in rat T‐cell maturation.
Alberto Varas +5 more
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Identification of a cytotoxic form of dimeric interleukin-2 in murine tissues. [PDF]
PLoS ONE, 2014 Interleukin-2 (IL-2) is a multi-faceted cytokine, known for promoting proliferation, survival, and cell death depending on the cell type and state. For example, IL-2 facilitates cell death only in activated T cells when antigen and IL-2 are abundant. The
Lucile E Wrenshall +7 more
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IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function
Cell Reports, 2023 Summary: Canonical interleukin-2 (IL-2) signaling via the high-affinity CD25-containing IL-2 receptor-Janus kinase (JAK)1,3-signal transducer and activator of transcription 5 (STAT5) pathway is essential for development and maintenance of CD4+CD25HiFoxp3+
Hao Sun +14 more
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Interleukins 4 and 13 in Asthma: Key Pathophysiologic Cytokines and Druggable Molecular Targets
Frontiers in Pharmacology, 2022 Interleukins (IL)-4 and -13 play a pivotal role in the pathobiology of type-2 asthma. Indeed, IL-4 is crucially involved in Th2 cell differentiation, immunoglobulin (Ig) class switching and eosinophil trafficking.
Corrado Pelaia +8 more
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P2Y2 Receptor and EGFR Cooperate to Promote Prostate Cancer Cell Invasion via ERK1/2 Pathway. [PDF]
PLoS ONE, 2015 As one member of G protein-coupled P2Y receptors, P2Y2 receptor can be equally activated by extracellular ATP and UTP. Our previous studies have proved that activation of P2Y2 receptor by extracellular ATP could promote prostate cancer cell invasion and ...
Wei-Hua Li +4 more
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Tumor site immune markers associated with risk for subsequent basal cell carcinomas. [PDF]
, 2011 BackgroundBasal cell carcinoma (BCC) tumors are the most common skin cancer and are highly immunogenic.ObjectiveThe goal of this study was to assess how immune-cell related gene expression in an initial BCC tumor biopsy was related to the appearance of ...
Andridge, Rebecca +13 more
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IL-1α and TNF-α Down-Regulate CRH Receptor-2 mRNA Expression in the Mouse Heart [PDF]
, 2001 Two receptors (CRH receptor type 1 and CRH receptor type 2) have been identified for the stress-induced neuropeptide, CRH and related peptides, urocortin, and urocortin II.
Coste, Sarah C. +4 more
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The IL-2 – IL-2 receptor pathway in health and disease: The role of the soluble IL-2 receptor
Clinical Immunology, 2020 The interleukin (IL)-2 - IL-2 receptor (IL-2R) pathway is important in immunity, but is also involved in maintenance of self-tolerance. This paradox is further complicated by shedding of the IL-2Rα chain, revealing soluble (s)IL-2R. Binding of IL-2 to sIL-2R may either reduce or enhance responses depending on the target cell being involved in immunity ...
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