The IL-2 – IL-2 receptor pathway: Key to understanding multiple sclerosis [PDF]
Journal of Translational Autoimmunity, 2021 The development, progression, diagnosis and treatment of autoimmune diseases, such as multiple sclerosis (MS), are convoluted processes which remain incompletely understood. Multiple studies demonstrated that the interleukin (IL)-2 – IL-2 receptor (IL-2R)
Daphne Peerlings +2 more
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Biological significance of soluble IL-2 receptor [PDF]
Mediators of Inflammation, 1993 A NUMBER of receptors for growth factors and differentiation antigens have been found to be secreted or released by cells. Following mononuclear cell (MNC) activation and interleukin-2 receptor (IL-2R) expression, a soluble form of the Alpha;-chain of IL-
Calogero Caruso +4 more
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An essential role for IL-2 receptor in regulatory T cell function [PDF]
Nat Immunol, 2016 Regulatory T cells (Treg cells), which have abundant expression of the interleukin 2 receptor (IL-2R), are reliant on IL-2 produced by activated T cells.
T. Chinen +9 more
semanticscholar +2 more sources
Structure-function relationships for the IL 2-receptor system. I. Localization of a receptor binding site on IL 2. [PDF]
The Journal of Immunology, 1986 Abstract Interleukin 2 (IL 2) modulates the growth and differentiation of a variety of lymphocyte subclasses through its interaction with a specific cell surface receptor. Although both IL 2 and its receptor have been characterized extensively, the location of interaction sites on the two molecules is unknown. Synthetic peptides based on
Li-Mei Kuo, R J Robb
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The IL-2 - IL-2 receptor pathway in health and disease: the role of the soluble IL-2 receptor.
Clinical Immunology, 2020 The interleukin (IL)-2 - IL-2 receptor (IL-2R) pathway is important in immunity, but is also involved in maintenance of self-tolerance. This paradox is further complicated by shedding of the IL-2Rα chain, revealing soluble (s)IL-2R. Binding of IL-2 to sIL-2R may either reduce or enhance responses depending on the target cell being involved in immunity ...
J. Damoiseaux
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Impact of serum levels of IL-18 and soluble IL-2 receptor on the clinical outcome of patients with diffuse large B-cell lymphoma treated with R-CHOP regimen [PDF]
Future Science OA, 2019 Aim & methods: To assess the impact of pretreatment serum levels of IL-18 and soluble IL-2 receptor (sIL-2R) on the clinical outcome of patients with diffuse large B-cell lymphoma treated with an R-CHOP protocol. Total 73 patients were included. Results:
Hussein M Khaled +4 more
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The characteristics of a monoclonal antibody that binds specifically to rat T lymphoblasts and inhibits IL 2 receptor functions. [PDF]
Journal of Immunology, 1983 In order to obtain an anti-interleukin 2 (IL 2) receptor antibody, we immunized mice with phorbol myristate acetate-pulsed rat T lymphoblasts. The spleen cells of the mice were fused with myeloma cells.
H. Osawa, T. Diamantstein
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Interleukin-2 (IL-2) Interacts With IL-2 Receptor Beta (IL-2Rβ): Its Potential to Enhance the Proliferation of CD4+ T Lymphocytes in Flounder (Paralichthys olivaceus) [PDF]
Frontiers in Immunology, 2020 Interleukin-2 (IL-2) is an important immunomodulatory cytokine that primarily promotes the activation, proliferation, and differentiation of CD4+ T helper subsets and CD4+ T regulatory cells.
Xiujuan Zhou +8 more
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Bypassing the cytokine sink: IL-2-independent IL-2 receptor signaling. [PDF]
Mol Ther, 2023 Luetkens T.
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Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene. [PDF]
Proceedings of the National Academy of Sciences, 1985 We demonstrate that purified interleukin 2 (IL-2) can directly upregulate IL-2 receptor expression on phytohemagglutinin-activated T lymphocytes maintained in culture until IL-2 receptor expression had markedly declined. The IL-2-induced increase in IL-2
J. Depper +5 more
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