Variation of Interleukin-8 (IL-8) Receptor Gene Based on Single Strand Conformation Polymorphism (SSCP) in Indonesian Friesian Holstein Dairy Cattle [PDF]
Animal Production: Indonesian Journal of Animal Production, 2010 Interleukin-8 (IL-8) receptor gene is response to bacterial invasion, endothelial and epithelial cells by release the chemokine interleukin-8 (IL-8). IL-8 mediates neutrophil function, allowing neutrophils to resolve bacterial infections by migrating ...
A Winaya, ID Rahayu
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Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies
Molecular Cancer, 2023 Interleukin-2 (IL-2) and its receptor (IL-2R) are essential in orchestrating immune responses. Their function and expression in the tumor microenvironment make them attractive targets for immunotherapy, leading to the development of IL-2/IL-2R-targeted ...
Shan Muhammad +4 more
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Targeting IL-2 receptors for diagnosis and therapy
Japanese Journal of Clinical Immunology, 1994 David L. Nelson
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Identification of a cytotoxic form of dimeric interleukin-2 in murine tissues. [PDF]
PLoS ONE, 2014 Interleukin-2 (IL-2) is a multi-faceted cytokine, known for promoting proliferation, survival, and cell death depending on the cell type and state. For example, IL-2 facilitates cell death only in activated T cells when antigen and IL-2 are abundant. The
Lucile E Wrenshall +7 more
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Interleukins 4 and 13 in Asthma: Key Pathophysiologic Cytokines and Druggable Molecular Targets
Frontiers in Pharmacology, 2022 Interleukins (IL)-4 and -13 play a pivotal role in the pathobiology of type-2 asthma. Indeed, IL-4 is crucially involved in Th2 cell differentiation, immunoglobulin (Ig) class switching and eosinophil trafficking.
Corrado Pelaia +8 more
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P2Y2 Receptor and EGFR Cooperate to Promote Prostate Cancer Cell Invasion via ERK1/2 Pathway. [PDF]
PLoS ONE, 2015 As one member of G protein-coupled P2Y receptors, P2Y2 receptor can be equally activated by extracellular ATP and UTP. Our previous studies have proved that activation of P2Y2 receptor by extracellular ATP could promote prostate cancer cell invasion and ...
Wei-Hua Li +4 more
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The IL-2 – IL-2 receptor pathway in health and disease: The role of the soluble IL-2 receptor
Clinical Immunology, 2020 The interleukin (IL)-2 - IL-2 receptor (IL-2R) pathway is important in immunity, but is also involved in maintenance of self-tolerance. This paradox is further complicated by shedding of the IL-2Rα chain, revealing soluble (s)IL-2R. Binding of IL-2 to sIL-2R may either reduce or enhance responses depending on the target cell being involved in immunity ...
openaire +4 more sources
Recent Advances in IL-13Rα2-Directed Cancer Immunotherapy
Frontiers in Immunology, 2022 Interleukin-13 receptor subunit alpha-2 (IL-13Rα2, CD213A), a high-affinity membrane receptor of the anti-inflammatory Th2 cytokine IL-13, is overexpressed in a variety of solid tumors and is correlated with poor prognosis in glioblastoma, colorectal ...
Karin M. Knudson +5 more
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IL-1α and TNF-α Down-Regulate CRH Receptor-2 mRNA Expression in the Mouse Heart [PDF]
, 2001 Two receptors (CRH receptor type 1 and CRH receptor type 2) have been identified for the stress-induced neuropeptide, CRH and related peptides, urocortin, and urocortin II.
Coste, Sarah C. +4 more
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Journal of Chemistry, 2022 The clinical use of high-dose IL-2 in cancer immunotherapy faces several drawbacks such as toxicity and unfavorable pharmacokinetic profile. These drawbacks can be avoided by inhibiting IL-2 interaction with the CD25 subunit, which is a component of the ...
Ahmed L. Alaofi
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