Results 21 to 30 of about 2,340,150 (306)
Phase I trial of an interleukin-2 (IL-2) fusion toxin (DAB486IL-2) in hematologic malignancies expressing the IL-2 receptor. [PDF]
Blood, 1992 DAB486IL-2 is a recombinant fusion toxin in which the native receptor binding domain of diphtheria toxin has been replaced with human interleukin-2 (IL-2). It selectively binds and intoxicates only cells that bear the high-affinity receptor for IL-2.
C. Lemaistre +8 more
semanticscholar +2 more sources
The IL-2/IL-2-Receptor Complex in the Maturation of Rat T-Cell Progenitors [PDF]
Clinical and Developmental Immunology, 1998 On the basis of both the interleukin‐2‐receptor (IL‐2R) α‐chain expression on 16‐day‐old fetal rat thymocytes and the occurrence of interleukin‐2 (IL‐2) mRNA‐containing cells early during rat thymus ontogeny, we have investigated the possible role of IL‐2/IL‐2R complex in rat T‐cell maturation.
Alberto Varas +5 more
doaj +4 more sources
Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation [PDF]
Proc Natl Acad Sci U S A, 2016 C. Gross +16 more
semanticscholar +2 more sources
Identification and cloning of a novel IL‐15 binding protein that is structurally related to the alpha chain of the IL‐2 receptor. [PDF]
EMBO Journal, 1995 J. Giri +9 more
semanticscholar +2 more sources
Targeting IL-2 receptors for diagnosis and therapy
Japanese Journal of Clinical Immunology, 1994 David L. Nelson
openalex +5 more sources
Recent Advances in IL-13Rα2-Directed Cancer Immunotherapy
Frontiers in Immunology, 2022 Interleukin-13 receptor subunit alpha-2 (IL-13Rα2, CD213A), a high-affinity membrane receptor of the anti-inflammatory Th2 cytokine IL-13, is overexpressed in a variety of solid tumors and is correlated with poor prognosis in glioblastoma, colorectal ...
Karin M. Knudson +5 more
doaj +1 more source
Journal of Immunology, 1995 Approximately 10% of peripheral CD4+ cells and less than 1% of CD8+ cells in normal unimmunized adult mice express the IL-2 receptor alpha-chain (CD25) molecules.
S. Sakaguchi +4 more
semanticscholar +1 more source
Journal of Chemistry, 2022 The clinical use of high-dose IL-2 in cancer immunotherapy faces several drawbacks such as toxicity and unfavorable pharmacokinetic profile. These drawbacks can be avoided by inhibiting IL-2 interaction with the CD25 subunit, which is a component of the ...
Ahmed L. Alaofi
doaj +1 more source
Journal of Experimental Medicine, 1994 Interleukin 15 (IL-15) is a novel cytokine that has recently been cloned and expressed. Whereas it has no sequence homology with IL-2, IL- 15 interacts with components of the IL-2 receptor (IL-2R).
W. E. Carson +9 more
semanticscholar +1 more source
IL-1α and TNF-α Down-Regulate CRH Receptor-2 mRNA Expression in the Mouse Heart [PDF]
, 2001 Two receptors (CRH receptor type 1 and CRH receptor type 2) have been identified for the stress-induced neuropeptide, CRH and related peptides, urocortin, and urocortin II.
Coste, Sarah C. +4 more
core +2 more sources