Results 21 to 30 of about 816,685 (307)
Selective Targeting of IL-15Rα Is Sufficient to Reduce Inflammation
Frontiers in Immunology, 2022 Cytokines are crucial molecules for maintaining the proper functioning of the immune system. Nevertheless, a dysregulation of cytokine expression could be involved in the pathogenesis of autoimmune diseases.
Dihia Meghnem +18 more
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Targeting IL-2 receptors for diagnosis and therapy
Japanese Journal of Clinical Immunology, 1994 David L. Nelson
openalex +5 more sources
Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies
Molecular Cancer, 2023 Interleukin-2 (IL-2) and its receptor (IL-2R) are essential in orchestrating immune responses. Their function and expression in the tumor microenvironment make them attractive targets for immunotherapy, leading to the development of IL-2/IL-2R-targeted ...
Shan Muhammad +4 more
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Abstracts from the 1997 Eastern Student Research Forum
McGill Journal of Medicine, 2020 N/A.
Eastern Student Research Forum
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Identification of a cytotoxic form of dimeric interleukin-2 in murine tissues. [PDF]
PLoS ONE, 2014 Interleukin-2 (IL-2) is a multi-faceted cytokine, known for promoting proliferation, survival, and cell death depending on the cell type and state. For example, IL-2 facilitates cell death only in activated T cells when antigen and IL-2 are abundant. The
Lucile E Wrenshall +7 more
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IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function
Cell Reports, 2023 Summary: Canonical interleukin-2 (IL-2) signaling via the high-affinity CD25-containing IL-2 receptor-Janus kinase (JAK)1,3-signal transducer and activator of transcription 5 (STAT5) pathway is essential for development and maintenance of CD4+CD25HiFoxp3+
Hao Sun +14 more
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Interleukins 4 and 13 in Asthma: Key Pathophysiologic Cytokines and Druggable Molecular Targets
Frontiers in Pharmacology, 2022 Interleukins (IL)-4 and -13 play a pivotal role in the pathobiology of type-2 asthma. Indeed, IL-4 is crucially involved in Th2 cell differentiation, immunoglobulin (Ig) class switching and eosinophil trafficking.
Corrado Pelaia +8 more
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P2Y2 Receptor and EGFR Cooperate to Promote Prostate Cancer Cell Invasion via ERK1/2 Pathway. [PDF]
PLoS ONE, 2015 As one member of G protein-coupled P2Y receptors, P2Y2 receptor can be equally activated by extracellular ATP and UTP. Our previous studies have proved that activation of P2Y2 receptor by extracellular ATP could promote prostate cancer cell invasion and ...
Wei-Hua Li +4 more
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The IL-2 – IL-2 receptor pathway in health and disease: The role of the soluble IL-2 receptor
Clinical Immunology, 2020 The interleukin (IL)-2 - IL-2 receptor (IL-2R) pathway is important in immunity, but is also involved in maintenance of self-tolerance. This paradox is further complicated by shedding of the IL-2Rα chain, revealing soluble (s)IL-2R. Binding of IL-2 to sIL-2R may either reduce or enhance responses depending on the target cell being involved in immunity ...
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Fish and Shellfish Immunology Reports, 2021 Interleukin-2 (IL-2) signals influence various lymphocyte subsets during differentiation, immune responses and homeostasis. IL-2 acts on different cells by binding to its receptors (IL-2R), which consists of three subunits, IL-2Rα (CD25), IL-2Rβ (CD122),
Pengfei Mu +4 more
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