Results 31 to 40 of about 1,307,311 (352)
PLoS ONE, 2012 The intestinal microflora is critical for normal development, with aberrant colonization increasing the risk for necrotizing enterocolitis (NEC). In contrast, probiotic bacteria have been shown to decrease its incidence.
Julie Mirpuri +7 more
doaj +1 more source
Development and function of invariant natural killer T cells producing T(h)2- and T(h)17-cytokines. [PDF]
PLoS Biology, 2012 There is heterogeneity in invariant natural killer T (iNKT) cells based on the expression of CD4 and the IL-17 receptor B (IL-17RB), a receptor for IL-25 which is a key factor in T(H)2 immunity.
Hiroshi Watarai +10 more
doaj +1 more source
Interleukin-2 druggability is modulated by global conformational transitions controlled by a helical capping switch. [PDF]
, 2020 Interleukin-2 (IL-2) is a small α-helical cytokine that regulates immune cell homeostasis through its recruitment to a high-affinity heterotrimeric receptor complex (IL-2Rα/IL-2Rβ/γc).
De Paula, Viviane S +5 more
core +1 more source
Endocannabinoid receptor blockade increases vascular endothelial growth factor and inflammatory markers in obese women with polycystic ovary syndrome [PDF]
, 2016 © 2016 John Wiley & Sons Ltd Context: Animal studies suggest that cannabinoid receptor-1 (CB-1) blockade reduces inflammation and neovascularization by decreasing vascular endothelial growth factor (VEGF) levels associated with a reduction in ...
Atkin, Stephen L. +4 more
core +1 more source
Current evidence for a modulation of low back pain by human genetic variants [PDF]
, 2009 The manifestation of chronic back pain depends on structural, psychosocial, occupational and genetic influences. Heritability estimates for back pain range from 30% to 45%. Genetic influences are caused by genes affecting intervertebral disc degeneration
Aberle +200 more
core +1 more source
Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation
Exploration of Immunology, 2021 Interleukin (IL)-22 is produced from immune cells such as T helper (Th)22 cells, Th17/22 cells, and group 3 innate lymphoid cells. IL-22 signals via the IL-22 receptor 1 (IL-22R1) and the IL-10 receptor 2 (IL-10R2).
Masutaka Furue, Mihoko Furue
doaj +1 more source
IL-15 sustains IL-7R-independent ILC2 and ILC3 development [PDF]
, 2017 The signals that maintain tissue-resident innate lymphoid cells (ILC) in different microenvironments are incompletely understood. Here we show that IL-7 receptor (IL-7R) is not strictly required for the development of any ILC subset, as residual cells ...
Bando, Jennifer K +5 more
core +2 more sources
Structure–Effect Relationships of Novel Semi-Synthetic Cannabinoid Derivatives
Frontiers in Pharmacology, 2019 Background: As a library of cannabinoid (CB) derivatives with (-)-trans-cannabidiol (CBD) or (-)-trans-cannabidivarin (CBDV) scaffold, we synthesized nine novel cannabinoids: 2-hydroxyethyl cannabidiolate (2-HEC), 2-hydroxypentyl cannabidiolate (2-HPC ...
Marcus R. Götz +13 more
doaj +1 more source
Role of IL-33 in inflammation and disease [PDF]
, 2011 Interleukin (IL)-33 is a new member of the IL-1 superfamily of cytokines that is expressed by mainly stromal cells, such as epithelial and endothelial cells, and its expression is upregulated following pro-inflammatory stimulation.
Miller, Ashley M.
core +3 more sources
Cell Reports, 2015 Although dendritic cell (DC) dysfunction in cancer is a well-recognized consequence of cancer-associated inflammation that contributes to immune evasion, the mechanisms that drive this process remain elusive.
Michael Tang +5 more
doaj +1 more source