Results 31 to 40 of about 50 (49)
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The IL-2/IL-2 receptor system: a target for rational immune intervention
Trends in Pharmacological Sciences, 1993The expression of interleukin 2 (IL-2), induction of its multisubunit receptor and subsequent interplay of this ligand with its receptor are pivotal events in T-cell activation. Our present understanding of the normal IL-2/IL-2R system and of disorders in this network in disease opens the possibility for more specific immune intervention.
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The Journal of Immunology, 1995
Abstract The biologic actions of IL-2 are mediated by the IL-2R, a multisubunit receptor complex displayed on the surface of lymphocytes and select other hematopoietic lineages. The IL-2R exhibits multiple affinities for IL-2 that result from the monomeric (alpha), heterodimeric (alpha beta and beta gamma), and heterotrimeric (alpha beta
M A, Goldsmith, M C, Amaral, W C, Greene
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Abstract The biologic actions of IL-2 are mediated by the IL-2R, a multisubunit receptor complex displayed on the surface of lymphocytes and select other hematopoietic lineages. The IL-2R exhibits multiple affinities for IL-2 that result from the monomeric (alpha), heterodimeric (alpha beta and beta gamma), and heterotrimeric (alpha beta
M A, Goldsmith, M C, Amaral, W C, Greene
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Highlight: IL-2 receptor signaling
Science Signaling, 2017Two papers reveal the consequences of altered interleukin-2 receptor signaling in T lymphocytes.
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Interleukin-2 (IL-2) and its receptor
Medical Oncology and Tumor Pharmacotherapy, 1986The interleukin-2 (IL-2) receptor system which is responsible for T-cell cycle progression is a unique hormone-receptor system in that both the ligand and the receptor need to be induced. In the present article I will review the biological and molecular characteristics of IL-2 and its receptor, as well as the differential triggering and growth ...
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European Journal of Immunology, 1995
AbstractMouse fibroblasts do not ordinarily express components for the interleukin‐2 receptor (IL‐2Rα, β, and γ). An analysis of these cells by reverse transcription followed by polymerase chain reaction, however, indicates the presence of transcripts specific for the IL‐2R β and γ genes. Transfection of the cDNA for the α chain of the human IL‐2R into
Bruno Azzarone +8 more
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AbstractMouse fibroblasts do not ordinarily express components for the interleukin‐2 receptor (IL‐2Rα, β, and γ). An analysis of these cells by reverse transcription followed by polymerase chain reaction, however, indicates the presence of transcripts specific for the IL‐2R β and γ genes. Transfection of the cDNA for the α chain of the human IL‐2R into
Bruno Azzarone +8 more
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Transcription and translation dependent induction of interleukin 2 (IL-2) and IL-2 receptors
Immunology Letters, 1984Our previous findings on the expression of Interleukin 2 (IL-2) receptors have shown that under the influence of certain drugs, it was possible to dissociate IL-2 production from the appearance of IL-2 receptors on human peripheral blood lymphocytes (PBL).
A.L. de Weck +3 more
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Differential Effects of IL-2 and IL-15 on Expression of IL-2 Receptor α
Biochemical and Biophysical Research Communications, 2001IL-2 and IL-15 have overlapping functions since they share the IL-2Rbetagamma receptor complex. However, each cytokine has a private alpha receptor namely IL-2Ralpha for IL-2 and IL-15Ralpha for IL-15. As a consequence the effects of the two cytokines may differ.
Adelkrim Alileche +2 more
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The Journal of Immunology, 1986
Abstract Interleukin 2 (IL 2) modulates the growth and differentiation of a variety of lymphocyte subclasses through its interaction with a specific cell surface receptor. Although both IL 2 and its receptor have been characterized extensively, the location of interaction sites on the two molecules is unknown. Synthetic peptides based on
L M, Kuo, R J, Robb
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Abstract Interleukin 2 (IL 2) modulates the growth and differentiation of a variety of lymphocyte subclasses through its interaction with a specific cell surface receptor. Although both IL 2 and its receptor have been characterized extensively, the location of interaction sites on the two molecules is unknown. Synthetic peptides based on
L M, Kuo, R J, Robb
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IL 2 receptor induction on human T lymphocytes: role for IL 2 and monocytes.
The Journal of Immunology, 1985Abstract In this report we studied the requirements for the activation and proliferation of highly purified human T lymphocytes. Purified T cells incubated for 3 days with PHA neither proliferate nor express IL 2 receptors as detected by FACS analysis with the use of anti-Tac antibodies.
H, Wakasugi +3 more
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The Journal of Immunology, 1985
Abstract The accessory cell requirements for the induction of the IL 2 receptor by the lectin Con A on murine T cell subsets were directly assayed with anti-IL 2 receptor monoclonal antibodies. Substantial levels of IL 2 receptor expression were induced on T lymphocytes of the MHC class I-restricted, suppressor/cytotoxic phenotype (L3T4-,
T R, Malek, J A, Schmidt, E M, Shevach
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Abstract The accessory cell requirements for the induction of the IL 2 receptor by the lectin Con A on murine T cell subsets were directly assayed with anti-IL 2 receptor monoclonal antibodies. Substantial levels of IL 2 receptor expression were induced on T lymphocytes of the MHC class I-restricted, suppressor/cytotoxic phenotype (L3T4-,
T R, Malek, J A, Schmidt, E M, Shevach
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