Results 41 to 50 of about 1,399,966 (352)

IL-2 regulation of soluble IL-2 receptor levels following thermal injury

Clinical and Experimental Immunology, 1992
SUMMARYIn the immunosuppresscd burn patient serum levels of both IL-2 and a soluble form of IL-2 receptor alpha (sIL-2Rα) are significantly elevated. Strikingly, the production of these markers by the in vitro activated patients' cells is decreased. This study examines the role of IL-2 in the decreased production of the sIL-2Rαin vitro in patients with
J A, Teodorczyk-Injeyan, B G, Sparkes, S, Lalani, W J, Peters, G B, Mills   +4 more
openaire   +3 more sources

Lactobacillus rhamnosus (LGG) regulates IL-10 signaling in the developing murine colon through upregulation of the IL-10R2 receptor subunit.

PLoS ONE, 2012
The intestinal microflora is critical for normal development, with aberrant colonization increasing the risk for necrotizing enterocolitis (NEC). In contrast, probiotic bacteria have been shown to decrease its incidence.
Julie Mirpuri, Ilya Sotnikov, Loren Myers, Timothy L Denning, Felix Yarovinsky, Charles A Parkos, Patricia W Denning, Nancy A Louis   +7 more
doaj   +1 more source

Development and function of invariant natural killer T cells producing T(h)2- and T(h)17-cytokines. [PDF]

PLoS Biology, 2012
There is heterogeneity in invariant natural killer T (iNKT) cells based on the expression of CD4 and the IL-17 receptor B (IL-17RB), a receptor for IL-25 which is a key factor in T(H)2 immunity.
Hiroshi Watarai, Etsuko Sekine-Kondo, Tomokuni Shigeura, Yasutaka Motomura, Takuwa Yasuda, Rumi Satoh, Hisahiro Yoshida, Masato Kubo, Hiroshi Kawamoto, Haruhiko Koseki, Masaru Taniguchi   +10 more
doaj   +1 more source

Current landscape and future prospects of interleukin-2 receptor (IL-2R) agonists in cancer immunotherapy

OncoImmunology
Immune checkpoint blockade (ICB) has significantly improved the survival for many patients with advanced malignancy. However, fewer than 50% of patients benefit from ICB, highlighting the need for more effective immunotherapy options.
Kengo Tanigawa, William L. Redmond
doaj   +1 more source

The onset of labor alters corticotropin-releasing hormone type 1 receptor variant expression in human myometrium : putative role of interleukin-1ß [PDF]

, 2007
CRH targets the human myometrium during pregnancy. The efficiency of CRH actions is determined by expression of functional receptors (CRH-R), which are dynamically regulated.
Grammatopoulos, Dimitris, Gu, Mei, Lehnert, Hendrik, Markovic, Danijela, Newton, Rob, Slater, Donna, Vatish, Manu   +6 more
core   +1 more source

Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene. [PDF]

Proceedings of the National Academy of Sciences, 1985
We demonstrate that purified interleukin 2 (IL-2) can directly upregulate IL-2 receptor expression on phytohemagglutinin-activated T lymphocytes maintained in culture until IL-2 receptor expression had markedly declined. The IL-2-induced increase in IL-2 receptor number is maximal within 12 hr, requires new RNA and protein synthesis, and is mediated by
J M, Depper, W J, Leonard, C, Drogula, M, Krönke, T A, Waldmann, W C, Greene   +5 more
openaire   +2 more sources

Structure–Effect Relationships of Novel Semi-Synthetic Cannabinoid Derivatives

Frontiers in Pharmacology, 2019
Background: As a library of cannabinoid (CB) derivatives with (-)-trans-cannabidiol (CBD) or (-)-trans-cannabidivarin (CBDV) scaffold, we synthesized nine novel cannabinoids: 2-hydroxyethyl cannabidiolate (2-HEC), 2-hydroxypentyl cannabidiolate (2-HPC ...
Marcus R. Götz, Marcus R. Götz, Juan A. Collado, Juan A. Collado, Javier Fernández-Ruiz, Bernd L. Fiebich, Laura García-Toscano, María Gómez-Cañas, Oskar Koch, Andreas Leha, Eduardo Muñoz, Carmen Navarrete, Maria R. Pazos, Ulrike Holzgrabe   +13 more
doaj   +1 more source

Induction of IL 2 receptor expression and cytotoxicity of thymocytes by stimulation with TCF1 [PDF]

, 1985
We investigated the role of T cell cytotoxicity inducing factor 1 (TCF1) in the induction of a cytotoxic T cell response. We found that help-deficient thymocyte cultures supplied with saturating amounts of purified IL 2 did not develop CTL in a 5-day ...
Diamantstein, T., Dröge, W., Falk, Werner, Kaltmann, B., Katzer, B., Krammer, P. H., Männel, D. N.   +6 more
core  

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers [PDF]

, 2017
Cytokine and growth-factor ligands typically signal through homo- or hetero-dimeric cell surface receptors via Janus Kinase (JAK/TYK), or Receptor Tyrosine Kinase (RTK)-mediated trans-phosphorylation.
Andrews, Bazan, Bazan, Bendall, Borden, Constantinescu, Delgoffe, Donohue, Fujiwara, Gil, Grant, Greenwell-Wild, Heller, Hoshino, Huising, Ihle, Jahn, Juntilla, Kasahara, Kawahara, Krutzik, Laporte, Lemmon, Levin, Levin, Levy, Marijanovic, Mitra, Moraga, Moraga, Moraga, Murray, Ng, O'Shea, Ohashi, Pattyn, Rafei, Saeed, Schaeffer, Sharif, Songyang, Spangler, Stroud, Thomas, Ullrich, Umemiya-Okada, van Boxel-Dezaire, Vercelli, Vignais, Wang, Wang, Wells, Wenzel, Zhu   +53 more
core   +2 more sources

Interleukin 2 (IL-2)-induced tyrosine phosphorylation of IL-2 receptor p75. [PDF]

The Journal of experimental medicine, 1990
We have recently established a mAb named TU11 mAb specific for the p75 subunit of human IL-2 receptor (IL-2R). The present study using TU11 mAb demonstrates the IL-2-induced phosphorylation of IL-2Rp75 on tyrosine residues in IL-2-dependent T cells. The tyrosine phosphorylation is mediated by the high affinity IL-2R, correlates with the IL-2-induced ...
H, Asao, T, Takeshita, M, Nakamura, K, Nagata, K, Sugamura   +4 more
openaire   +2 more sources