Results 41 to 50 of about 1,307,311 (352)

Soluble pIasma IL-2 receptors and maIaria

Clinical and Experimental Immunology, 1993
SUMMARYPIasma levels of soluble IL-2 receptor (sIL-2R) were measured by immunoassay in 180 individuals, aged 1–70 years, living in a maIaria-endemic community in West Africa. slL-2R levels were compared with age. maIaria parasitacmia. maIaria-associated morbidity and cellular immune responses to PIasmodium falciparum antigens.
Stephen Allen, Brian Greenwood, E.M. Riley, P. Rowe   +3 more
openaire   +4 more sources

Developmental and Anatomical Patterns Of IL-2 Gene Expression in Vivo in The Murine Thymus [PDF]

, 1993
Interleukin-2 (IL-2) is a potent growth factor that mature T lymphocytes synthesize and use as a proliferation signal. Much controversy has arisen concerning whether it is used to drive the extensive proliferation of immature pre-T cells in the thymus ...
Rothenberg, Ellen V., Yang-Snyder, Julia A.   +1 more
core   +3 more sources

Current landscape and future prospects of interleukin-2 receptor (IL-2R) agonists in cancer immunotherapy

OncoImmunology
Immune checkpoint blockade (ICB) has significantly improved the survival for many patients with advanced malignancy. However, fewer than 50% of patients benefit from ICB, highlighting the need for more effective immunotherapy options.
Kengo Tanigawa, William L. Redmond
doaj   +1 more source

IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function

Cell Reports, 2023
Summary: Canonical interleukin-2 (IL-2) signaling via the high-affinity CD25-containing IL-2 receptor-Janus kinase (JAK)1,3-signal transducer and activator of transcription 5 (STAT5) pathway is essential for development and maintenance of CD4+CD25HiFoxp3+
Hao Sun, Ho-Sup Lee, Sarah Hyun-Ji Kim, Mikhael Fernandes de Lima, Alexandre R. Gingras, Qinyi Du, Wilma McLaughlin, Jailail Ablack, Miguel A. Lopez-Ramirez, Frederic Lagarrigue, Zhichao Fan, John T. Chang, Derek VanDyke, Jamie B. Spangler, Mark H. Ginsberg   +14 more
doaj  

Nucleotide sequence of mouse IL-2 receptor cDNA and its comparison with the human IL-2 receptor sequence

Nucleic Acids Research, 1985
We have cloned cDNA encoding the mouse interleukin-2 (IL-2) receptor from a murine T cell line, CTLL using human IL-2 receptor cDNA as probe. COS 7 cells transfected with the cDNA expressed the antigen recognized by the monoclonal antibody against the murine IL-2 receptor. The cDNA identified 4 species of mRNA (4.5, 3.5, 2.2 and 1.5 kb) of the mouse IL-
Norio Ishida, Hisao Osawa, Toshio Nikaido, Junji Yodoi, Hisataka Sabe, Akira Shimuzu, Shunichi Takeda, Tibor Diamantstein, Tasuku Honjo, Shigeru Kondo   +9 more
openaire   +4 more sources

Qualitatively Different T Cell Phenotypic Responses to IL-2 versus IL-15 Are Unified by Identical Dependences on Receptor Signal Strength and Duration [PDF]

, 2013
IL-2 and IL-15 are common γ-chain family cytokines involved in regulation of T cell differentiation and homeostasis. Despite signaling through the same receptors, IL-2 and IL-15 have non-redundant roles in T cell biology, both physiologically and at the ...
Arneja, Abhinav, Gabrovsek, Laura, Johnson, Hannah, Lauffenburger, Douglas A, White, Forest M.   +4 more
core   +2 more sources

Soluble P2X7 Receptor Is Elevated in the Plasma of COVID-19 Patients and Correlates With Disease Severity

Frontiers in Immunology, 2022
Inflammation is a tightly coordinated response against bacterial and viral infections, triggered by the production of pro-inflammatory cytokines. SARS-CoV-2 infection induces COVID-19 disease, characterized by an inflammatory response mediated through ...
Julio García-Villalba, Laura Hurtado-Navarro, Alejandro Peñín-Franch, Cristina Molina-López, Laura Martínez-Alarcón, Diego Angosto-Bazarra, Alberto Baroja-Mazo, Pablo Pelegrin, Pablo Pelegrin   +8 more
doaj   +1 more source

Decreased Interleukin-4 Release from the Neurons of the Locus Coeruleus in Response to Immobilization Stress [PDF]

, 2016
It has been demonstrated that immobilization (IMO) stress affects neuroimmune systems followed by alterations of physiology and behavior. Interleukin-4 (IL-4), an anti-inflammatory cytokine, is known to regulate inflammation caused by immune challenge ...
An, Kyungeh, Lee, Hyun-ju, Park, Hyun-Jung, Shim, Insop, Starkweather, Angela   +4 more
core   +4 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Induction of IL 2 receptor expression and cytotoxicity of thymocytes by stimulation with TCF1 [PDF]

, 1985
We investigated the role of T cell cytotoxicity inducing factor 1 (TCF1) in the induction of a cytotoxic T cell response. We found that help-deficient thymocyte cultures supplied with saturating amounts of purified IL 2 did not develop CTL in a 5-day ...
Diamantstein, T., Dröge, W., Falk, Werner, Kaltmann, B., Katzer, B., Krammer, P. H., Männel, D. N.   +6 more
core