Results 51 to 60 of about 1,399,966 (352)

A Quality Improvement Initiative to Standardize Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma [PDF]

, 2017
The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is pivotal to the pathophysiology of widespread allergic diseases mediated by type 2 helper T cell (Th2) responses, including asthma and atopic dermatitis. The emergence of human TSLP as a
Beyaert, Rudi, Braun, Harald, Dansercoer, Ann, De Winter, Hans, Hammad, Hamida, Lambrecht, Bart, Lippens, Guy, Lopez, Juan, Pauwels, Kris, Peelman, Frank, Savvides, Savvas, Tavernier, Jan, Van Rompaey, Dries, Vandenberghe, Isabel, Verstraete, Kenneth   +14 more
core   +3 more sources

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale, Alessandro Crocoli, Giuseppe Maria Milano, Pierluigi Di Paolo, Francesca Diomedi Camassei, Ida Russo, Annalisa Serra   +6 more
wiley   +1 more source

Toll-like Receptor 2 Activation Promotes Tumor Dendritic Cell Dysfunction by Regulating IL-6 and IL-10 Receptor Signaling

Cell Reports, 2015
Although dendritic cell (DC) dysfunction in cancer is a well-recognized consequence of cancer-associated inflammation that contributes to immune evasion, the mechanisms that drive this process remain elusive.
Michael Tang, Jun Diao, Hongtao Gu, Ismat Khatri, Jun Zhao, Mark S. Cattral   +5 more
doaj   +1 more source

Tissue signals imprint ILC2 identity with anticipatory function. [PDF]

, 2018
Group 2 innate lymphoid cells (ILC2s) are distributed systemically and produce type 2 cytokines in response to a variety of stimuli, including the epithelial cytokines interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP).
Eckalbar, Walter L, Erle, David J, Lee, Jinwoo, Liang, Hong-Erh, Locksley, Richard M, Molofsky, Ari B, Nussbaum, Jesse C, Ricardo-Gonzalez, Roberto R, Schneider, Christoph, Vaka, Dedeepya, Van Dyken, Steven J   +10 more
core  

Interleukin-1 blockade in recently decompensated systolic heart failure: study design of the recently decompensated heart failure anakinra response trial (RED-HART) [PDF]

, 2015
Heart Failure (HF) is a clinical syndrome characterized by dyspnea, fatigue, and poor exercise capacity due to impaired cardiac function. The incidence of HF is increasing and represents the leading cause of hospitalization in the United States among ...
Abbate Antonio, Abouzaki Nayef, Arena Ross, BIONDI ZOCCAI, GIUSEPPE, Canada Justin, CARBONE, SALVATORE, Oddi Erdle Claudia, Valle Raleigh Juan, Van Tassell Benjamin W   +8 more
core   +1 more source

IL-2 receptor gene expression and IL-2 production by human preterm newborns' cells [PDF]

Clinical and Experimental Immunology, 1993
SUMMARYIL-2 receptor (IL-2R) gene expression in human umbilical cord blood mononuclear cells (CBMC) of preterm and term newborns was examined following stimulation for 18 h with phytohaemagglutinin (PHA) and compared with that of adult peripheral blood mononuclear cells (PBMC: mothers and control group).
H, Bessler, L, Sirota, I, Notti, T, Milo, M, Djaldetti   +4 more
openaire   +2 more sources

Potential Early Risk Biomarkers for Reduced Forced Expiratory Volume in Children Post‐Hematopoietic Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We sought to identify potential early risk biomarkers for lung disease in children post‐allogeneic HCT. Patients with pulmonary function tests 3 months post‐transplant and plasma samples between days 7 and 14 post‐HCT were included. Six of 27 subjects enrolled had reduced forced expiratory volume 1 (FEV1) z scores.
Isabella S. Small, Pi Chun Cheng, April L. Rahrig, Courtney M. Rowan   +3 more
wiley   +1 more source

IL-2/IL-2Rβγ signaling in pruriceptors drives neuroimmune mechanisms of nivolumab-induced persistent itch

Journal of Neuroinflammation
Background Immune checkpoint inhibitor (ICI) therapy frequently induces pruritus as a cutaneous immune-related adverse event, affecting 13–25% of patients treated with anti–PD-1 antibodies.
Lixuan Li, Huijuan Zhao, Jing Guo, Huaizhi Li, Aiping Li, Xiyuan Ba, Fengling Wu, Nan Li, Xu Liu, Xiaoping Wang, Yuhui Luo, Changyu Jiang   +11 more
doaj   +1 more source

Structural truncation of IL-1R2 enhances the anti-inflammatory activity of HeLa cells

Cell Structure and Function
Interleukin-1 receptor type 2 (IL-1R2) functions as a decoy receptor that suppresses IL-1-induced inflammatory signaling. Both membrane-bound IL-1R2 (WT IL-1R2) and its soluble form (sIL-1R2) bind interleukin-1α (IL-1α) at the cell surface or in the ...
Isao Kato, Yoshiyuki Hagiwara, Masatake Asano, Jin Inoue, Yosuke Yamazaki, Maki Yuguchi, Akiko Yamada, Mariko Tsunoda, Saya Imaoka   +8 more
doaj   +1 more source