Results 61 to 70 of about 1,307,311 (352)

Identification and expression analysis of IL-2 receptors in large yellow croaker (Larimichthys crocea)

Fish and Shellfish Immunology Reports, 2021
Interleukin-2 (IL-2) signals influence various lymphocyte subsets during differentiation, immune responses and homeostasis. IL-2 acts on different cells by binding to its receptors (IL-2R), which consists of three subunits, IL-2Rα (CD25), IL-2Rβ (CD122),
Pengfei Mu, Jieying Huo, Min Sun, Xinhua Chen, Jingqun Ao   +4 more
doaj  

Interleukin-1 blockade in heart failure with preserved ejection fraction: rationale and design of the Diastolic Heart Failure Anakinra Response Trial 2 (D-HART2) [PDF]

, 2017
Heart failure with preserved ejection fraction (HFpEF) now accounts for the majority of con-firmed HF cases in the United States. However, there are no highly effective evidence-basedtreatments currently available for these patients.
Abbate, Antonio, Abouzaki, Nayef, Arena, Ross, Biondi-zoccai, Giuseppe, Buckley, Leo F., Canada, Justin M., Carbone, Salvatore, Dixon, Dave L., Oddi-erdle, Claudia, Trankle, Cory R., Van Tassell, Benjamin W.   +10 more
core   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Long COVID (PASC) Is Maintained by a Self-Sustaining Pro-Inflammatory TLR4/RAGE-Loop of S100A8/A9 > TLR4/RAGE Signalling, Inducing Chronic Expression of IL-1b, IL-6 and TNFa: Anti-Inflammatory Ezrin Peptides as Potential Therapy

Immuno, 2022
Long COVID, also referred to as Post-Acute Sequelae of COVID (PASC), is probably triggered during SARS-CoV-2 infection and acute COVID-19 by SARS-CoV-2 Spike-protein binding and hyper-activating the cell-membrane expressed Receptor for Advance Glycation ...
Rupert Donald Holms
doaj   +1 more source

Tissue signals imprint ILC2 identity with anticipatory function. [PDF]

, 2018
Group 2 innate lymphoid cells (ILC2s) are distributed systemically and produce type 2 cytokines in response to a variety of stimuli, including the epithelial cytokines interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP).
Eckalbar, Walter L, Erle, David J, Lee, Jinwoo, Liang, Hong-Erh, Locksley, Richard M, Molofsky, Ari B, Nussbaum, Jesse C, Ricardo-Gonzalez, Roberto R, Schneider, Christoph, Vaka, Dedeepya, Van Dyken, Steven J   +10 more
core  

G2A Attenuates Propionibacterium acnes Induction of Inflammatory Cytokines in Human Monocytes. [PDF]

, 2017
Background:Acne vulgaris is a disease of the pilosebaceous unit characterized by increased sebum production, hyperkeratinization, and immune responses to Propionibacterium acnes (PA).
Agak, George W, Garbán, Hermes J, Hisaw, Lisa D, Kao, Stephanie, Kim, Jenny, Liu, Philip T, Marinelli, Laura J, Park, Andrew J, Pirouz, Aslan, Qin, Min, Thiboutot, Diane   +10 more
core   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Pleiotropic Effects of IL-2 on Cancer: Its Role in Cervical Cancer

Mediators of Inflammation, 2016
IL-2 receptor (IL-2R) signalling is critical for normal lymphocyte proliferation, but its role in cervical cancer is not fully understood. The receptor is composed of three chains: IL-2α, IL-2β, and IL-2γ.
Arturo Valle-Mendiola, Adriana Gutiérrez-Hoya, María del Carmen Lagunas-Cruz, Benny Weiss-Steider, Isabel Soto-Cruz   +4 more
doaj   +1 more source

A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo expansion of CD8 and NK cells

Scientific Reports, 2021
The use of recombinant interleukin-2 (IL-2) as a therapeutic protein has been limited by significant toxicities despite its demonstrated ability to induce durable tumor-regression in cancer patients.
Katherine E. Harris, Kyle J. Lorentsen, Harbani K. Malik-Chaudhry, Kaitlyn Loughlin, Harish Medlari Basappa, Sharon Hartstein, Ghenima Ahmil, Nicole S. Allen, Brian C. Avanzino, Aarti Balasubramani, Andrew A. Boudreau, Karen Chang, Maria-Cristina Cuturi, Laura M. Davison, Dennis M. Ho, Suhasini Iyer, Udaya S. Rangaswamy, Preethi Sankaran, Ute Schellenberger, Roland Buelow, Nathan D. Trinklein   +20 more
doaj   +1 more source