Results 231 to 240 of about 961,718 (249)

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

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IL-38 in modulating hyperlipidemia and its related cardiovascular diseases

International Immunopharmacology, 2022
Hyperlipidemia is confirmed to be associated with several health problems that include the combination of diabetes mellitus, obesity, and hypertension, ie, metabolic syndrome. Although the lipid-lowering therapy is an effective treatment in hyperlipidemia and its related cardiovascular diseases (CVDs), the persistence of high atherosclerotic risk is ...
Min, Lai, Hua, Peng, Xijie, Wu, Xiang, Chen, Bin, Wang, Xin, Su   +5 more
openaire   +2 more sources

Powerful anti‐inflammatory action of luteolin: Potential increase with IL‐38

BioFactors, 2021
AbstractLuteolin belongs to the flavone family originally present in some fruits and vegetables, including olives, which decrease intracellular levels of reactive oxygen species (ROS) following the activation of various stimuli. Luteolin inhibits inflammation, a complex process involving immune cells that accumulate at the site of infectious or non ...
Conti, Pio, Caraffa, Alessandro, Gallenga, Carla E, Ross, Rhiannon, Kritas, Spyros K, Frydas, Ilyas, Younes, Alì, Di Emidio, Paolo, Ronconi, Gianpaolo, Pandolfi, Franco   +9 more
openaire   +2 more sources

IL-38 as an early predictor of the ischemic stroke prognosis

Cytokine, 2021
Ischemic stroke is caused by a sudden neurological defect following a vascular occlusion and elicits a local and systemic inflammation in brain tissue. Interleukin-38 is an anti-inflammatory cytokine associated with ischemic and inflammatory diseases. This study was designed to analyze the effect of tPA therapy on interleukin-38 serum level changes and
Maryam Zare Rafie, Abdolreza Esmaeilzadeh, Abdolreza Ghoreishi, Safa Tahmasebi, Elham Faghihzadeh, Reza Elahi   +5 more
openaire   +2 more sources

IL-38, a potential therapeutic agent for lupus, inhibits lupus progression

Inflammation Research, 2022
Previous studies reported that IL-38 was abnormally expressed in patients with systemic lupus erythematosus (SLE). However, the involvement of IL-38 in the pathophysiology of SLE remains unknown.The therapeutic potential of IL-38 was tested in pristane-treated wild-type (WT) and IL-38-/- mice. Thus, SLE was induced via pristane in WT and IL-38-/- mice.
Wang-Dong, Xu, Lin-Chong, Su, Lu, Fu, You-Yu, Lan, Xiao-Yan, Liu, Qi, Huang, Qian, Wu, Jie, Zhou, An-Fang, Huang   +8 more
openaire   +2 more sources

IL-38 alleviates concanavalin A-induced liver injury in mice

International Immunopharmacology, 2016
Interleukin (IL)-38 is a poorly characterized cytokine of the IL-1 family with anti-inflammatory activity. The role of IL-38 in liver injury remains unknown. We have investigated the potential effect of hydrodynamic-based gene delivery to express human IL-38 in mice with concanavalin A (Con A)-induced liver injury.
Xianli, Yuan, Yan, Li, Xiuhe, Pan, Xiao, Peng, Gaihuan, Song, Wenwen, Jiang, Qiaoyan, Gao, Mingcai, Li   +7 more
openaire   +2 more sources

Association between IL-38 and inflammatory indicators in patients with bacterial pneumonia

Cytokine, 2023
IL-38, a recently discovered cytokine of IL-1 family, exerts immunoregulatory activities in multi-type inflammatory diseases. However, its expression level and underlying clinical importance for IL-38 in respiratory bacterial infections remain unknown.Thirty-five patients with bacterial pneumonia and twenty age- and gender- matched healthy individuals ...
Xiaoyu Sun, Jie Zhou, Wenjuan Huang, Bo Wang, Yi Zhang, Liang Duan, Weixian Chen   +6 more
openaire   +2 more sources

Contribution of IL-38 in Lung Immunity during Pseudomonas Aeruginosa-induced Pneumonia

Shock, 2022
ABSTRACT Objective: Interleukin-38 (IL-38), a new type of cytokine, is involved in processes such as tissue repair, inflammatory response, and immune response. However, its function in pneumonia caused by Pseudomonas aeruginosa (P. aeruginosa)
Qiang, Wei, Xi, Chen, Xia, Chen, Zhongzhen, Yuan, Chuanjiang, Wang   +4 more
openaire   +2 more sources