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Increased synthesis and intestinal expression of IL-39 in patients with inflammatory bowel disease
Immunologic Research, 2023IL-39 (Interleukin-39) is a heterodimeric cytokine composed of IL-23p19 and EBI3 (Epstein-Barr virus-induced gene 3) subunits. Despite the evidence that correlates the role of IL-39 in regulating inflammation, its expression in the intestinal microenvironment of IBD (inflammatory bowel disease) patients is still unknown.
Gabriela Fonseca-Camarillo +4 more
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IL-39 acts as a friend to pancreatic cancer
Medical Oncology, 2018Pancreatic cancer is the most lethal digestive cancer and the fourth leading cause of cancer death in the US. IL-39, a heterodimer of p19 and EBI3, is a newly found cytokine and its role in the pathogenesis of neoplasia has not been studied yet.
Alicia A. Manning +10 more
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The role of IL-39 in autoimmune diseases: From general to immunopathogenesis
CytokineIL-39, a cytokine from the IL-12 family that appears to be produced primarily by B cells, consists of the IL-23p19 and Ebi3 subunits, which signal through IL-23R/gp130 to activate STAT1/STAT3. Some studies suggest elevated IL-39 levels in certain autoimmune conditions, such as relapsing-remitting multiple sclerosis (RRMS), ankylosing spondylitis (AS ...
Parisa, Ahmadi +5 more
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Biomarkers in Medicine, 2017
To investigate the changes and significance of circulating IL-39 in patients with acute coronary syndrome (ACS).Serum IL-39 levels in ACS patients and normal coronary arteries were measured. The correlations of IL-39 with high-sensitivity CRP, cTnI, N-terminal of the prohormone brain natriuretic peptide (NTproBNP) and left ventricular ejection fraction
Yu, Luo +6 more
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To investigate the changes and significance of circulating IL-39 in patients with acute coronary syndrome (ACS).Serum IL-39 levels in ACS patients and normal coronary arteries were measured. The correlations of IL-39 with high-sensitivity CRP, cTnI, N-terminal of the prohormone brain natriuretic peptide (NTproBNP) and left ventricular ejection fraction
Yu, Luo +6 more
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IL-39/IL-39R signaling drives acute graft-versus-host disease
BloodAbstract Background: Acute graft-versus-host disease (aGVHD) is a major cause of morbidity and non-relapse mortality (NRM) following allogeneic hematopoietic cell transplantation (allo-HCT), emphasizing the need for novel biomarkers and therapeutic interventions. Among cytokine families, IL-12
Denggang Fu +13 more
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Neurology Asia
Background: Multiple sclerosis (MS) is an immune-mediated, chronic inflammatory demyelinating disease of the central nervous system (CNS). Hence, there is a need to identify more biomarkers that may assist in developing new therapeutic strategies. This study aims to compare the levels of interleukin (IL)-35, IL-39, and oncostatin M (OSM) in patients ...
Sina Vakili +5 more
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Background: Multiple sclerosis (MS) is an immune-mediated, chronic inflammatory demyelinating disease of the central nervous system (CNS). Hence, there is a need to identify more biomarkers that may assist in developing new therapeutic strategies. This study aims to compare the levels of interleukin (IL)-35, IL-39, and oncostatin M (OSM) in patients ...
Sina Vakili +5 more
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Journal of Craniofacial Surgery
Background: Sjögren syndrome (SS) is a chronic autoimmune disease characterized by lymphocytic infiltration of the salivary and lacrimal glands. The CXCL10–CXCR3 axis is considered central in promoting inflammation and damaging the gland, while oral microbial dysbiosis may amplify immune activation.
Muthana Kamal Ali +2 more
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Background: Sjögren syndrome (SS) is a chronic autoimmune disease characterized by lymphocytic infiltration of the salivary and lacrimal glands. The CXCL10–CXCR3 axis is considered central in promoting inflammation and damaging the gland, while oral microbial dysbiosis may amplify immune activation.
Muthana Kamal Ali +2 more
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IL-39 Reproducible clinical dermatological imaging with commercially available digital cameras
Pigment Cell Research, 2003Y. Vander Haeghen, J. M. Naeyaert
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