Results 1 to 10 of about 18,317 (191)
CRISPR-Edited CART With GM-CSF Knockout and Auto Secretion of IL6 and IL1 Blockers in Patients With Hematologic Malignancy [PDF]
Cell Discovery, 2021 Revolutionary CART therapy still faces the challenge of severe cytokine release syndrome (CRS). While IL6 and IL1 have been demonstrated as essential contributors, GM-CSF is one of the most abundant inflammatory cytokines secreted by CART and has also ...
Yan Yi, Xiaoshan Chai, Yongjing Zhang
exaly +4 more sources
Anti-Inflammatory Activity of a Demineralized Bone Matrix: An In Vitro Pilot Study
Applied Sciences, 2022 Demineralized bone matrix (DBM) is commonly used for the reconstruction of bone defects. Early graft consolidation involves a transient inflammatory process. It is, however, unclear whether DBM can modulate this process.
Layla Panahipour +5 more
doaj +2 more sources
NF-α, IL6, IL1-α, IL-10 and TGF-β1 Gene Expression in Iranian Acute Myeloid Leukemia Patients
Basic & Clinical Cancer Research, 2023 Acute myeloid leukemia is a heterogeneous clonal disorder of blood-producing cells that are among the most common malignant disorders in adults. The purpose of this study was to examine the gene expression of TNF-α, IL6, IL1-α, IL-10, and TGF-β1 at diagnosis in acute myeloid leukemia.
Ali Ghorbani Ranjbary
exaly +2 more sources
Plants, 2023 The pink stem borer (PSB), Sesamia cretica (Lepidoptera: Noctuidae) purple-lined borer (PLB), Chilo agamemnon (Lepidoptera: Crambidae) and European corn borer Ostrinia nubilalis, (Lepidoptera: Crambidae) are considered the most devastating insect pests ...
Saad N. AL-Kahtani +5 more
doaj +2 more sources
Basic & Clinical Cancer Research, 2023 Acute myeloid leukemia as one of the most common malignant disorders in adults is a heterogeneous clonal disorder of blood producing cells. The aim of this study was to analyze the expression of TNF-α, IL6, IL1-α, IL-10 and TGF-β1 gene in acute myeloid ...
Ali Ghorbani Ranjbary +1 more
doaj +1 more source
Wound Age Estimation: Pro-inflammatory Cytokines versus Immuno-histochemistry [PDF]
The Egyptian Journal of Forensic Sciences and Applied Toxicology, 2022 Rationale and background: In forensic medical investigations, it is an important matter to determine whether a wound found on autopsy was inflicted before or after death and, if inflicted ante-mortem, how long before death it was sustained.
Nevein El-Dessouky +4 more
doaj +1 more source
Cell Discovery, 2021 IL6 is one of the most elevated cytokines during chimeric antigen receptor (CAR) T cell cytokine release syndrome (CRS), and IL6R blockade by Tocilizumab has successfully relieved the most life-threatening aspects of CRS in patients.
Lei Xue +12 more
doaj +1 more source
P03-016 - ANTI IL1 refractory CINCA respondes to ANTI IL6 [PDF]
Pediatric Rheumatology, 2013 CINCA is thought to be mainly due to a dysregulation of IL1 synthesis and many patients respond to IL1 inhibition. The role of other cytokines in CINCA disease pathogenesis is less clear.
Dueckers, G +4 more
openaire +1 more source
Tumor-targeting properties of novel immunocytokines based on murine IL1β and IL6 [PDF]
Protein Engineering, Design and Selection, 2014 There is an increasing biotechnological interest in 'arming' therapeutic antibodies with bioactive payloads. Many antibody-cytokine fusion proteins (immunocytokines) have been described and some of these biopharmaceuticals have progressed to clinical studies.
Hess Christian, Neri Dario
openaire +4 more sources
Biologics in COVID-19 So Far: Systematic Review
Pharmaceuticals, 2022 This systematic review aimed to reevaluate the available evidence of the use of biologics as treatment candidates for the treatment of severe and advanced COVID-19 disease; what are the rationale for their use, which are the most studied, and what kind ...
Milton Arias +3 more
doaj +1 more source