Results 1 to 10 of about 18,106 (157)

Contribution of host-related immune factors to frequency and severity of infections in lung transplant recipients [PDF]

Respiratory Research
Background Lung transplantation (LTx) is associated with an increased risk of infection, causing notable morbidity and mortality at all phases post-transplantation.
Jiri Kufa, Petra Schneiderova, Samuel Genzor, Marketa Trajerova, Petr Jakubec, Jan Mizera, Monika Zurkova, Eva Kriegova   +7 more
doaj   +2 more sources

CRISPR-edited CART with GM-CSF knockout and auto secretion of IL6 and IL1 blockers in patients with hematologic malignancy

Cell Discovery, 2021
Revolutionary CART therapy still faces the challenge of severe cytokine release syndrome (CRS). While IL6 and IL1 have been demonstrated as essential contributors, GM-CSF is one of the most abundant inflammatory cytokines secreted by CART and has also ...
Yan Yi, Xiaoshan Chai, Yongjing Zhang
exaly   +2 more sources

Evaluation of salivary and serum Exosomal mRNAs as biomarkers for the diagnosis and prognosis of oral squamous cell carcinoma [PDF]

Scientific Reports
Minimally-invasive or non-invasive biomarkers from serum and saliva hold significant promise for real-time monitoring of oral squamous cell carcinoma (OSCC).
Sarwareddy Kartik Kumar, Neeharika Kanaparthi, Sesuraj Babiola Annes, Rajesh V. Bendre, Nagalla Balakrishna, Saroj Kumar, Arsheed Hussain Hakeem, Manda Venkata Sasidhar   +7 more
doaj   +2 more sources

Exploratory Analysis of the Inhibitory Effects of Propranolol on NLRP3 and Pyrin Inflammasomes. [PDF]

ACR Open Rheumatol
Objective Propranolol, a nonselective beta receptor blocking agents, impacts cAMP levels and is commonly used to treat hypertension and hemangioma in children and adults. Although there are reports indicating its anti‐inflammatory properties, the exact mechanism is not fully understood. Methods Murine and human monocytes and macrophages were exposed to
de Jong RJ, Neullens CT, Swoboda A, Saers M, Berger P, Hebbar Subramanyam S, Wiener A, Ohl K, Weiskirchen R, Noels H, Kallinich T, Guthrie J, Kessel C, Tenbrock K.   +13 more
europepmc   +2 more sources

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1-FOXO1 Signaling to Enhance ILC3s Effector Function. [PDF]

Adv Sci (Weinh)
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Yang H, Zhang Y, Feng S, Ma X, Feng J, Wang J, Gao J, Pan A, Wu D, Ding K, Zheng C, Lv Q, Hu L.   +12 more
europepmc   +2 more sources

Interleukin-1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis. [PDF]

Adv Sci (Weinh)
During pancreatitis, IL‐1α is released from necrotic acinar cells. In response to IL‐1α, pancreatic fibroblasts release chemokines and cytokines that regulate the recruitment of immune cells to the damaged organ. Furthermore, IL‐1α primes fibroblasts, resulting in increased tissue fibrosis during chronic pancreatitis.
Mazloum H, Buchholz S, Schifter H, Ameling S, Steil L, Becker BL, Hammer E, Homuth G, Völker U, Bröker BM, Zierke L, Weiss FU, Glaubitz J, Sendler M.   +13 more
europepmc   +2 more sources

Wound Age Estimation: Pro-inflammatory Cytokines versus Immuno-histochemistry [PDF]

The Egyptian Journal of Forensic Sciences and Applied Toxicology, 2022
Rationale and background: In forensic medical investigations, it is an important matter to determine whether a wound found on autopsy was inflicted before or after death and, if inflicted ante-mortem, how long before death it was sustained.
Nevein El-Dessouky, Manal Ismail, Laila Rashed, Wael Ibraheem, Mohamed El-Gebely   +4 more
doaj   +1 more source

Pro-Inflammatory Properties of Salivary Gland-Derived Fibroblasts—Implications in Sjögren’s Disease [PDF]

Cells
Salivary gland dysfunction is a hallmark of Sjögren’s disease (SjD). Here, we investigated the pro-inflammatory properties of salivary gland-derived fibroblasts (SGF) that were cultured from minor salivary gland (MSG) tissues of patients with SjD and ...
Matthias Brunner, Daniel Guggisberg, Marco Sprecher, Ondrej Pastva, Kristina Bürki, Miranda Houtman, Marco Kreuzer, Sara Andrea Krättli, Laura Jahnke, Mila Roceri, Rémy Bruggmann, Muriel Elhai, Britta Maurer, Thomas M. Marti, Caroline Ospelt, Kerstin Klein   +15 more
doaj   +2 more sources

Chimeric antigen receptor T cells self-neutralizing IL6 storm in patients with hematologic malignancy

Cell Discovery, 2021
IL6 is one of the most elevated cytokines during chimeric antigen receptor (CAR) T cell cytokine release syndrome (CRS), and IL6R blockade by Tocilizumab has successfully relieved the most life-threatening aspects of CRS in patients.
Lei Xue, Yan Yi, Qianwen Xu, Li Wang, Xiaohui Yang, Yongjing Zhang, Xuefei Hua, Xiaoshan Chai, Junjie Yang, Yaxin Chen, Guangshi Tao, Biliang Hu, Xingbing Wang   +12 more
doaj   +1 more source

Anti-Inflammatory Activity of a Demineralized Bone Matrix: An In Vitro Pilot Study

Applied Sciences, 2022
Demineralized bone matrix (DBM) is commonly used for the reconstruction of bone defects. Early graft consolidation involves a transient inflammatory process. It is, however, unclear whether DBM can modulate this process.
Layla Panahipour, Anes Omerbasic, Azarakhsh Oladzad Abbasabadi, Jila Nasirzade, Zahra Kargarpour, Reinhard Gruber   +5 more
doaj   +1 more source