Results 31 to 40 of about 18,317 (191)
Fas-threshold Signalling in MSCs Promotes Pancreatic Cancer Progression and Metastasis [PDF]
, 2021 Mesenchymal stem cells (MSCs) belong to the tumour microenvironment and have been implicated in tumour progression. We found that the number of MSCs significantly increased in tumour-burdened mice driven by Fas-threshold signalling.
Zwacka, Ralf +11 more
core +1 more source
Correlation of VEGF production with IL1α and IL6 secretion by human pituitary adenoma cells [PDF]
European Journal of Endocrinology, 2005 Objectives: Vascular endothelial growth factor (VEGF) is considered to be the most important angiogenic factor involved in the neovascularisation of solid tumours. Regulatory molecules include cytokines and growth factors. Interleukin (IL)1 and IL6 have both been shown to regulate VEGF levels in a variety of tissues.
S A, Borg +4 more
openaire +2 more sources
Cells, 2021 Eosinophils contribute to allergic inflammation in asthma in part via elaboration of a complex milieu of soluble mediators. Human bronchial fibroblasts (HBF) respond to stimulation by these mediators by acquiring a pro-inflammatory profile including ...
Ksenija Bernau +8 more
doaj +1 more source
Impact of Primary RPE Cells in a Porcine Organotypic Co-Cultivation Model
Biomolecules, 2022 The pathological events of age-related macular degeneration are characterized by degenerative processes involving the photoreceptor cells, retinal pigment epithelium (RPE), and the Bruch’s membrane as well as choroidal alterations.
Natalie Wagner +6 more
doaj +1 more source
, 2023 <div>Abstract<p>A hallmark of pancreatic ductal adenocarcinoma (PDAC) is the presence of a dense, desmoplastic stroma and the consequent altered interactions between cancer cells and their surrounding tumor microenvironment (TME) that promote disease progression, metastasis, and chemoresistance.
Nipun B. Merchant +13 more
openaire +1 more source
Animals, 2020 This study aimed to investigate the effects of maternal lipopolysaccharide (LPS) challenge and dietary fat sources on colostrum quality and inflammatory response in sows.
Tiande Zou +4 more
doaj +1 more source
An ex vivo model for studying hepatic schistosomiasis and the effect of released protein from dying eggs. [PDF]
PLoS Neglected Tropical Diseases, 2015 BACKGROUND:We report the use of an ex vivo precision cut liver slice (PCLS) mouse model for studying hepatic schistosomiasis. In this system, liver tissue is unfixed, unfrozen, and alive for maintenance in culture and subsequent molecular analysis ...
Geoffrey N Gobert +4 more
doaj +1 more source
Bone & Joint Research, 2022 Aims: Insufficient treatment response in rheumatoid arthritis (RA) patients requires novel treatment strategies to halt disease progression. The potential benefit of combination of cytokine-inhibitors in RA is still unclear and needs further ...
Silvia Hayer +8 more
doaj +1 more source
Scientific Reports, 2021 Toll-like receptor (TLR) family signature has been implicated in sepsis etiopathology. We aimed to evaluate the genetic profile of TLR pathway-related key genes; the myeloid differentiation protein 88 (MYD88), IL1 receptor-associated kinase 1 (IRAK1 ...
Nouran B. AbdAllah +6 more
doaj +1 more source