Results 51 to 60 of about 18,317 (191)

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

Increased IL6 plasma levels in indolent systemic mastocytosis patients are associated with high risk of disease progression

, 2016
Systemic mastocytosis (SM) is a heterogeneous disease with altered interleukin (IL)-6 and IL13 plasma levels. However, no study has simultaneously investigated the plasma levels of IL1 beta, IL6, IL13, CCL23 and clusterin in SM at diagnosis and ...
A Matito, J M Morgado, Morgado, JM, Matarraz, S, L Escribano, Goncalves Grunho Teodosio, Cristina, A Rodriguez-Caballero, A Orfao, Munoz-Gonzalez, J, Escribano, L, S Matarraz, Mayado, A, Matito, A, J I Muñoz-González, Alvarez-Twose, I, L Sanchez-Muñoz, I Álvarez-Twose, Orfao, A, A C Garcia-Montero, Sanchez-Munoz, L, Caldas, C, A Mayado, C Muñiz, C Teodosio, Muniz, C, C Caldas, Jara-Acevedo, M, M Jara-Acevedo, Rodriguez-Caballero, A, Garcia-Montero, AC   +29 more
core   +1 more source

Interleukin‐1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis

Advanced Science, EarlyView.
During pancreatitis, IL‐1α is released from necrotic acinar cells. In response to IL‐1α, pancreatic fibroblasts release chemokines and cytokines that regulate the recruitment of immune cells to the damaged organ. Furthermore, IL‐1α primes fibroblasts, resulting in increased tissue fibrosis during chronic pancreatitis.
Hala Mazloum, Shenja Buchholz, Hanna Schifter, Sabine Ameling, Leif Steil, Ben Lewin Becker, Elke Hammer, Georg Homuth, Uwe Völker, Barbara M. Bröker, Lukas Zierke, Frank Ulrich Weiss, Juliane Glaubitz, Matthias Sendler   +13 more
wiley   +1 more source

EFFECT OF ESTROGEN REPLACEMENT ON BONE METABOLISM AND CYTOKINES IN SURGICAL MENOPAUSE

, 1995
The effect of oestrogen replacement on bone metabolism and serum cytokine levels (IL1,IL6) was investigated in surgical menopause. The study included 40 female subjects; 10 healthy premenopausal women underwent total hysterectomy without oophorectomy ...
CANTATORE FP, CARROZZO M., SELVAGGI L, LACANNA R, SASSANELLI E, INGROSSO AM, LOVERRO, Giuseppe, R. LACANNA, CANTATORE, FRANCESCO PAOLO, G. LOVERRO, E. SASSANELLI, A. M. INGROSSO, L. SELVAGGI, M. CARROZZO   +13 more
core   +1 more source

Ageing and Osteoarthritis Synergically Affect Human Synoviocyte Cells: An In Vitro Study on Sex Differences

, 2022
Osteoarthritis is a chronic inflammatory disease that affects all of the joints, especially those of the elderly. Aging is a natural and irreversible biological process implicated in the pathophysiology of many chronic diseases, such as osteoarthritis ...
Milena Fini, Contartese, Deyanira, Fini, Milena, Pagani, Stefania, Monica De Mattei, Matilde Tschon, De Mattei, Monica, Deyanira Contartese, Veronica Borsari, Borsari, Veronica, Veronesi, Francesca, Stefania Pagani, Tschon, Matilde, Francesca Veronesi   +13 more
core   +1 more source

IL-1 and TNF mediates IL-6 signaling at the maternal-fetal interface during intrauterine inflammation

Frontiers in Immunology
IntroductionIL6 signaling plays an important role in triggering labor and IL6 is an established biomarker of intrauterine infection/inflammation (IUI) driven preterm labor (PTL).
Pietro Presicce, Cynthia Roland, Paranthaman Senthamaraikannan, Monica Cappelletti, McKensie Hammons, Lisa A. Miller, Alan H. Jobe, Claire A. Chougnet, Emily DeFranco, Suhas G. Kallapur   +9 more
doaj   +1 more source

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng, Wen Gao, Jonathan Do, Danli Lu, Ying‐Wei Lan, Andreas Damianos, Gautam Verma, Ali Al Siraj, Isabella Lowry, Lance Peter, Nicholas E. Banovich, Fei Sun, Hua He, Tanya V. Kalin, Vladimir V. Kalinichenko   +14 more
wiley   +1 more source

Supplementary Figures & Legends from Targeting Tumor–Stromal IL6/STAT3 Signaling through IL1 Receptor Inhibition in Pancreatic Cancer

, 2023
<p>Supplementary Fig. S1-S4 and figure legends.</p>
Nipun B. Merchant, Jashodeep Datta, Nagaraj S. Nagathihalli, Sulagna Banerjee, Xi Chen, Yuguang Ban, Zhen Gao, Supriya Srinivasan, Anna Bianchi, Iago De Castro Silva, Siddharth Mehra, Xizi Dai, Samara Singh, Austin R. Dosch   +13 more
openaire   +1 more source

The immunological landscape of the area postrema in neuromyelitis optica spectrum disorders

Brain Pathology, EarlyView.
Aquaporin‐4 antibody‐positive neuromyelitis spectrum disorder is characterized by large tissue destructive lesions in medulla, spinal cord, and optic nerves, with only partial recovery from clinical symptoms, and by lesions with very little tissue destruction and mostly complete recovery from clinical symptoms, as seen in the area postrema ...
Qian Yu, Yoshiki Takai, Naoya Yamazaki, Sarah Brandl, Katharina M. Mair, Thibault Bouderlique, Maria Eleni Kastriti, Igor Adameyko, Romana Höftberger, Markus Reindl, Jan Bauer, Monika Bradl   +11 more
wiley   +1 more source

Combined inhibition of IL1, CXCR1/2, and TGFβ signaling pathways modulates in-vivo resistance to anti-VEGF treatment

, 2016
Resistance of tumors to antiangiogenic therapies is becoming increasingly relevant. We recently identified interleukin-1 (IL1), CXC receptors (CXCR)1/2 ligands, and transforming growth factor β (TGFβ) among the proinflammatory factors that were expressed
Aldo Scarpa, CATALDO, Ivana, Piro, Geny, ZANOTTO, MARCO, TORTORA, GIAMPAOLO, Maria M. Mina, Carmine Carbone, Geny Piro, Carbone, Carmine, MELISI, Davide, Marco Zanotto, Zanini, Silvia, MINA, Maria Mihaela, Ivana Cataldo, Silvia Zanini, SCARPA, Aldo, Anna Tamburrino, Federico Boschi, Tamburrino, Anna, BOSCHI, Federico, Andrea Sbarbati, Giampaolo Tortora, SBARBATI, Andrea, Davide Melisi   +23 more
core   +1 more source