Results 21 to 30 of about 18,106 (157)

Interleukin-1α Is a Critical Mediator of the Response of Human Bronchial Fibroblasts to Eosinophilic Inflammation

Cells, 2021
Eosinophils contribute to allergic inflammation in asthma in part via elaboration of a complex milieu of soluble mediators. Human bronchial fibroblasts (HBF) respond to stimulation by these mediators by acquiring a pro-inflammatory profile including ...
Ksenija Bernau, Jonathan P. Leet, Heather Floerke, Ellen M. Bruhn, Andrea L. Noll, Ivy S. McDermott, Stephane Esnault, Nizar N. Jarjour, Nathan Sandbo   +8 more
doaj   +1 more source

Impact of Primary RPE Cells in a Porcine Organotypic Co-Cultivation Model

Biomolecules, 2022
The pathological events of age-related macular degeneration are characterized by degenerative processes involving the photoreceptor cells, retinal pigment epithelium (RPE), and the Bruch’s membrane as well as choroidal alterations.
Natalie Wagner, Armin Safaei, José Hurst, Pia A. Vogt, H. Burkhard Dick, Stephanie C. Joachim, Sven Schnichels   +6 more
doaj   +1 more source

Effects of Dietary Fat Sources during Late Gestation on Colostrum Quality and Mammary Gland Inflammation in Lipopolysaccharide-Challenged Sows

Animals, 2020
This study aimed to investigate the effects of maternal lipopolysaccharide (LPS) challenge and dietary fat sources on colostrum quality and inflammatory response in sows.
Tiande Zou, Wenzhuo Wei, Shanchuan Cao, Hongfu Zhang, Jingbo Liu   +4 more
doaj   +1 more source

An ex vivo model for studying hepatic schistosomiasis and the effect of released protein from dying eggs. [PDF]

PLoS Neglected Tropical Diseases, 2015
BACKGROUND:We report the use of an ex vivo precision cut liver slice (PCLS) mouse model for studying hepatic schistosomiasis. In this system, liver tissue is unfixed, unfrozen, and alive for maintenance in culture and subsequent molecular analysis ...
Geoffrey N Gobert, Sujeevi K Nawaratna, Marina Harvie, Grant A Ramm, Donald P McManus   +4 more
doaj   +1 more source

Analysis of combined deficiency of interleukin-1 and -6 versus single deficiencies in TNF-mediated arthritis and systemic bone loss

Bone & Joint Research, 2022
Aims: Insufficient treatment response in rheumatoid arthritis (RA) patients requires novel treatment strategies to halt disease progression. The potential benefit of combination of cytokine-inhibitors in RA is still unclear and needs further ...
Silvia Hayer, Birgit Niederreiter, Marlene Kalkgruber, Konrad Wanic, Julia Maißner, Josef S. Smolen, Daniel Aletaha, Stephan Blüml, Kurt Redlich   +8 more
doaj   +1 more source

A prominent role for the IL1 pathway and IL15 in susceptibility to chronic cavitary pulmonary aspergillosis. [PDF]

, 2014
Chronic cavitary pulmonary aspergillosis (CCPA) is a progressive lung condition with a 10-30% annual mortality. Although overtly immunocompetent, some immunogenetic defect in patients is likely.
Smith, Nicola L D, Hankinson, J, Smith, N.L.D., Hankinson, J., Bowyer, P., Denning, D.W., Bowyer, P, Simpson, A; id_orcid, Denning, D W; id_orcid, Simpson, A.   +9 more
core   +1 more source

Rat pro-inflammatory cytokine and cytokine related mRNA quantification by real-time polymerase chain reaction using SYBR green

BMC Immunology, 2004
Background Cytokine mRNA quantification is widely used to investigate cytokine profiles, particularly in small samples. Real-time polymerase chain reaction is currently the most reliable method of quantifying low-level transcripts such as cytokine and ...
Chancerelle Yves, Agay Diane, Clarençon Didier, Mathieu Jacques, Alonso Antonia, Birot Olivier, Mouret Catherine, Peinnequin André, Multon Eric   +8 more
doaj   +1 more source

MYD88, NFKB1, and IL6 transcripts overexpression are associated with poor outcomes and short survival in neonatal sepsis

Scientific Reports, 2021
Toll-like receptor (TLR) family signature has been implicated in sepsis etiopathology. We aimed to evaluate the genetic profile of TLR pathway-related key genes; the myeloid differentiation protein 88 (MYD88), IL1 receptor-associated kinase 1 (IRAK1 ...
Nouran B. AbdAllah, Eman A. Toraih, Essam Al Ageeli, Hala Elhagrasy, Nawal S. Gouda, Manal S. Fawzy, Ghada M. Helal   +6 more
doaj   +1 more source

Expression of mRNA for IL1 beta, IL6 and TGF beta 1 in developing human bone and cartilage.

, 1994
Using in situ hybridization, we investigated the expression of mRNA for interleukin-1 beta (IL1 beta), interleukin-6 (IL6), and transforming growth factor-beta-1 (TGF beta 1) in sections of developing bone in human osteophytes.
M Gowen, K Merry, R A Dodds, A Littlewood   +3 more
core   +1 more source

PENGARUH KONSUMSI MINUMAN BEROKSIGEN TERHADAP INFLAMASI DAN KAPASITAS ANTIOKSIDAN PENDERITA PENYAKIT-PARU-OBSTRUKTIF-KRONIK (PPOK) [Influence of Oxygenated Water Consumption in Chronic-Obstructive-Pulmonary-Disease (COPD) Patients]

Jurnal Teknologi dan Industri Pangan, 2014
Chronic Obstructive Pulmonary Disease (COPD) is one of the leading cause of death in the world that represents an important public health problem. Oxygenated water is water added with high concentration of oxygen such that the oxygen concentration is ...
Fransiska Rungkat Zakaria, Intan Nurul Azni*, Elvira Syamsir, Amalia KM., Cholid Yamani   +4 more
doaj   +1 more source