Results 21 to 30 of about 35,795 (270)

GATA4 Is Sufficient to Establish Jejunal Versus Ileal Identity in the Small IntestineSummary

Cellular and Molecular Gastroenterology and Hepatology, 2017
Background & Aims: Patterning of the small intestinal epithelium along its cephalocaudal axis establishes three functionally distinct regions: duodenum, jejunum, and ileum.
Cayla A. Thompson, Kevin Wojta, Kirthi Pulakanti, Sridhar Rao, Paul Dawson, Michele A. Battle   +5 more
doaj   +2 more sources

Intestinal epithelial Smad7 drives purine metabolic dysregulation and ileal inflammation [PDF]

Journal of Biomedical Science
Background and aims Defects of the gut epithelial barrier and counter-regulatory mechanisms are a prerequisite for the onset of intestinal inflammation in patients with inflammatory bowel diseases (IBD).
Federica Laudisi, Mattia Alberto Serra, Lorenzo Tomassini, Massimo Claudio Fantini, Gustavo Monasterio, Ning He, Eduardo Maria Sommella, Angela Ortenzi, Giuseppe Sigismondo Sica, Francesca Zorzi, Teresa Pacifico, Ombretta Melaiu, Cristiano De Stefanis, Valentina D’Oria, Carmine Stolfi, Ivan Monteleone, Eduardo Javier Villablanca, Giovanni Monteleone   +17 more
doaj   +2 more sources

Ileal microbial microbiome and its secondary bile acids modulate susceptibility to nonalcoholic steatohepatitis in dairy goats

Microbiome
Background Liver damage from nonalcoholic steatohepatitis (NASH) presents a significant challenge to the health and productivity of ruminants. However, the regulatory mechanisms behind variations in NASH susceptibility remain unclear. The gut‒liver axis,
Yue Wang, Xiaodong Chen, Sharon A. Huws, Guanghao Xu, Jing Li, Jianrong Ren, Jingyi Xu, Le Luo Guan, Junhu Yao, Shengru Wu   +9 more
doaj   +2 more sources

Congenital intestinal lymphangiectasia [PDF]

Vojnosanitetski Pregled, 2011
Background. Congenital intestinal lymphangiectasia is a disease which leads to protein losing enteropathy. Tortous, dilated lymphatic vessels in the intestinal wall and mesenterium are typical features of the disease.
Popović Dušan Đ., Špuran Milan, Alempijević Tamara, Krstić Miodrag, Đuranović Srđan, Kovačević Nada, Damjanović Svetozar, Micev Marjan   +7 more
doaj   +1 more source

Curcumin β-D-Glucuronide Modulates an Autoimmune Model of Multiple Sclerosis with Altered Gut Microbiota in the Ileum and Feces

Frontiers in Cellular and Infection Microbiology, 2021
We developed a prodrug type of curcumin, curcumin monoglucuronide (CMG), whose intravenous/intraperitoneal injection achieves a high serum concentration of free-form curcumin.
Sundar Khadka, Seiichi Omura, Fumitaka Sato, Kazuto Nishio, Hideaki Kakeya, Ikuo Tsunoda   +5 more
doaj   +1 more source

Loss of Sonic hedgehog leads to alterations in intestinal secretory cell maturation and autophagy. [PDF]

PLoS ONE, 2014
Intestinal epithelial cells express the Sonic and Indian hedgehog ligands. Despite the strong interest in gut hedgehog signaling in GI diseases, no studies have specifically addressed the singular role of intestinal epithelial cell Sonic hedgehog ...
Jessica Gagné-Sansfaçon, Joannie M Allaire, Christine Jones, François Boudreau, Nathalie Perreault   +4 more
doaj   +1 more source

Association of Baseline Luminal Narrowing With Ileal Microbial Shifts and Gene Expression Programs and Subsequent Transmural Healing in Pediatric Crohn Disease [PDF]

, 2021
BackgroundTransmural healing (TH) is associated with better long-term outcomes in Crohn disease (CD), whereas pretreatment ileal gene signatures encoding myeloid inflammatory responses and extracellular matrix production are associated with stricturing ...
Noe, Joshua, Jason M Shapiro, Nicholas J Ollberding, Anil G Jegga, David Hercules, Allison D Ta, Jonathan R Dillman, Jegga, Anil G, Ta, Allison D, Anthony Otley, Otley, Anthony, Jegga, Anil G., Xavier, Ramnik, Melvin B Heyman, Heyman, Melvin B, Subra Kugathasan, Alazraki, Adina L, Kim, Sandra, Snapper, Scott, Dillman, Jonathan R., Heyman, Melvin B., Kirschner, Barbara, Robert Baldassano, Adina L Alazraki, Joshua Noe, Baldassano, Robert, Kellermayer, Richard, Maria Oliva-Hemker, Dubinsky, Marla, Scott Snapper, Sandra Kim, Yael Haberman, Jeffrey Hyams, Lee A Denson, Markowitz, James, Shapiro, Jason M, Ta, Allison D., Richard Kellermayer, Shapiro, Jason M., Kugathasan, Subra, Pfefferkorn, Marian, Ramnik Xavier, Shervin Rabizadeh, Hyams, Jeffrey, Haberman, Yael, Dillman, Jonathan R, Alazraki, Adina L., Rabizadeh, Shervin, Oliva-Hemker, Maria, James Markowitz, Marian Pfefferkorn, Hercules, David, Barbara Kirschner, Marla Dubinsky, Denson, Lee A, Rebekah Karns, Denson, Lee A., Karns, Rebekah, Ollberding, Nicholas J, Ollberding, Nicholas J.   +59 more
core   +1 more source

A peculiar case of intususception in a pregnant woman: A diagnostic challenge

Radiology Case Reports, 2023
Adult intussusception presents a diagnostic challenge given its non-specific symptoms. It is not as common as in infants and young children. Traditionally, diagnostic steps are invariably fit for normal adults, but not in pregnancy which faces certain ...
Firdaus Hayati, MD, Asyraf Mohd Zuki, MBBCh, Ming Chin Lim, MD, Pradeep Chand Chandran, MD, MRCS Ed, Nornazirah Azizan, MD, Mohamed Arif Hameed Sultan, MD, Muhamad Hud Muhamad Zin, MD, Khasnizal Abdul Karim, MD, MS   +7 more
doaj   +1 more source

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Ileal ulcer in asymptomatic individuals. Is this Crohn?

Journal of Coloproctology, 2012
The endoscopic finding of ileal ulcers, alone or in small number, is not usual, but when it occurs in asymptomatic patients, an impasse may be generated regarding the action to be taken, since the medical literature is unclear as to how to proceed in ...
Carlos Henrique Marques dos Santos
doaj   +1 more source