Results 41 to 50 of about 2,175,268 (253)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Rare presentations of small bowel endometriosis

DEN Open
Despite endometriosis being a relatively common chronic gynecological condition in women of childbearing age, small bowel endometriosis is rare. Presentations can vary from completely asymptomatic to reported symptoms of abdominal pain, bloating, and ...
Anthony Sakiris, Ezaam Naik Fraz, Arvinf Rajandran, Jason Smith, Benjamin Allen, Sooraj Pillai, Pradeep Kakkadasam Ramaswamy, Sneha John   +7 more
doaj   +1 more source

Ileocolic Intussusception in Adults: A Rare Presentation of an Underlying Malignancy

Acta Médica Portuguesa
N ...
Catarina Rolo Santos, Frederico Nazareth, Zara Maria Caetano   +2 more
doaj   +1 more source

Brain-to-gut trafficking of alpha-synuclein by CD11c+ cells in a mouse model of Parkinson’s disease

Nature Communications, 2023
Inflammation in the brain and gut is a critical component of several neurological diseases, such as Parkinson’s disease (PD). One trigger of the immune system in PD is aggregation of the pre-synaptic protein, α-synuclein (αSyn).
Rhonda L. McFleder, Anastasiia Makhotkina, Janos Groh, Ursula Keber, Fabian Imdahl, Josefina Peña Mosca, Alina Peteranderl, Jingjing Wu, Sawako Tabuchi, Jan Hoffmann, Ann-Kathrin Karl, Axel Pagenstecher, Jörg Vogel, Andreas Beilhack, James B. Koprich, Jonathan M. Brotchie, Antoine-Emmanuel Saliba, Jens Volkmann, Chi Wang Ip   +18 more
doaj   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Betaine, organic acids and inulin do not affect ileal and total tract nutrient digestibility or microbial fermentation in piglets [PDF]

, 2009
The study was conducted to investigate the effects of betaine alone or combined with organic acids and inulin on ileal and total tract nutrient digestibilities and intestinal microbial fermentation characteristics in piglets.
Eklund, M., Jezierny, D., Ratriyanto, A., Sauer, N., Mosenthin, R.   +4 more
core  

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Idiopathic Primary Calcium Oxalate‐Rich Enteroliths Causing Small Bowel Obstruction in a Young Woman: A Rare Case Report

Clinical Case Reports
Primary enterolithiasis must be considered in subacute bowel obstruction, even in patients lacking classic risk factors. Persistent, unexplained abdominal symptoms necessitate repeat imaging and heightened clinical suspicion, as timely surgical resection
Usama Hanif, Abdur Rehman, Hafsa Azam Arshad Raja, Ibia Nawaz, Muhammad Iqbal, Usman Qureshi, Sidra Yousaf, Rahmat Gul Omarzai   +7 more
doaj   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Secondary bile acid ursodeoxycholic acid alters weight, the gut microbiota, and the bile acid pool in conventional mice.

PLoS ONE, 2021
Ursodeoxycholic acid (commercially available as ursodiol) is a naturally occurring bile acid that is used to treat a variety of hepatic and gastrointestinal diseases.
Jenessa A Winston, Alissa Rivera, Jingwei Cai, Andrew D Patterson, Casey M Theriot   +4 more
doaj   +1 more source